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Ephrin Receptor

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Ephrin receptors (Ephs) are a group of receptors that are activated in response to binding ephrin. Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Ephs and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell interactions for Eph receptor activation. Eph/ephrin signaling has been implicated in the regulation of a host of processes critical to embryonic development including axon guidance, formation of tissue boundaries, cell migration, and segmentation. Additionally, Eph/epherin signaling has recently been identified to play a critical role in the maintenance of several processes during adulthood including long-term potentiation, angiogenesis, and stem cell differentiation and cancer. The ability of Ephs and ephrins to mediate a variety of cell-cell interactions places the Eph/ephrin system in an ideal position to regulate a variety of different biological processes during embryonic development.

Products Related to Ephrin Receptor(13)

  • GC11134 structure
    GC11134ALW-II-41-27
    CAS: 1186206-79-0
    Purity: >98.00%

    ALW-II-41-27 es un inhibidor de la tirosina quinasa de la familia Eph con un IC50 de 11 nM para inhibir Eph2.

  • GC14332 structure
    GC14332NVP-BHG712
    CAS: 940310-85-0
    Purity: >99.50%

    NVP-BHG712 es un inhibidor de la autofosforilaciÓn de la cinasa EphB4 activo por vÍa oral, con valores IC50 de 3,3 nM y 3,0 nM para EphA2 y EphB4, respectivamente.

  • GC18168 structure
    GC18168JI-101
    CAS: 900573-88-8
    Purity: >99.00%

    JI-101 es un inhibidor multicinasa disponible por vÍa oral de VEGFR2, PDGFRβ y EphB4 con una potente actividad anticancerÍgena.

  • GC25367 structure
    GC25367Ehp-inhibitor-1
    CAS: 861249-59-4
    Purity: >98%

    Ehp-inhibitor-1 (Ehp inhibitor 2) is an Eph family tyrosine kinase inhibitor that targets Eph receptors.

  • GC31752 structure
    GC31752Tesevatinib (XL-647)
    CAS: 781613-23-8
    Purity: >98.00%

    Tesevatinib (XL-647) (XL-647; EXEL-7647; KD-019) es un inhibidor de la tirosina cinasa multidiana disponible por vÍa oral; inhibe la cinasa EGFR, ErbB2, KDR, Flt4 y EphB4 con IC50 de 0,3, 16, 1,5, 8,7 y 1,4 nM.

  • GC35053 structure
    GC35053123C4
    CAS: 2034159-30-1
    Purity: >98%

    123C4 es un agonista potente, selectivo y competitivo del receptor tirosina quinasa EPHA4, con un valor Ki de 0,65 μM.

  • GC36782 structure
    GC36782NVP-BHG712 isomer
    CAS: 2245892-85-5
    Purity: >99.00%

    El isÓmero NVP-BHG712, un regioisÓmero de NVP-BHG712, muestra una uniÓn no enlazada conservada a EPHA2 y EPHB4.

  • GC50137 structure
    GC50137KYL
    CAS: 676657-00-4
    Purity: >98%

    KYL, un péptido antagonista, se dirige selectivamente al receptor EphA4.

  • GC64856 structure
    GC64856UniPR129
    CAS: 1639159-47-9
    Purity: >99.00%

    UniPR129 es un potente antagonista de Eph/ephrin. UniPR129 tiene el potencial para la investigaciÓn de la enfermedad del cÁncer.

  • GC68647 structure
    GC68647ALW-II-49-7
    CAS: 1135219-23-6
    Purity: >98.00%

    ALW-II-49-7 es un inhibidor selectivo de la quinasa de EphB2 con un valor de IC 50 de 40nM

  • GC69258 structure
    GC69258Ifabotuzumab
    CAS: 2147698-66-4
    Purity: >95.00%

    Ifabotuzumab (KB004) is an IgG1κ antibody that targets EphA3 (KD=610 pM). Ifabotuzumab can induce apoptosis in tumor cells and activate antibody-dependent cell-mediated cytotoxicity (ADCC), destroying the tumor vascular system. Ifabotuzumab can reduce CCR10+ cells in idiopathic pulmonary fibrosis (IPF) patients, improving lung fibrosis.

  • GC70097 structure
    GC70097Urolithin D
    CAS: 131086-98-1
    Purity: >98.00%

    Urolithin D es un antagonista competitivo y reversible del receptor EphA. Urolithin D muestra selectividad intraclase.

  • GC74367 structure
    GC74367Targefrin
    CAS: 3031514-44-7
    Purity: >99.00%

    Targefrin es un potente agente epha2, actúa como un antagonista.