KYL |
| Catalog No.GC50137 |
KYL, un péptido antagonista, se dirige selectivamente al receptor EphA4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 676657-00-4
Sample solution is provided at 25 µL, 10mM.
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EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 μM); inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 μM). Prevents AβO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). Neuroprotective.
Lamberto et al (2012) Distinctive binding of three antagonistic peptides to the ephrin-binding pocket of the EphA4 receptor. Biochem. J. 445 47 PMID:22489865 |Vargas et al (2014) EphA4 activation of c-Abl mediates synaptic loss and LTP blockade caused by amyloid-β oligomers. PLoS One. 9 e92309 PMID:24658113
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)
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