H-Met-Met-OH is a dipeptide composed of two methionine residues, with the properties of fast absorption, low energy consumption, and less easy saturation [1]. Supplementation of H-Met-Met-OH in low-fishmeal diets enhances the digestive proteolytic activity, improving the digestibility of dry matter and protein, and eventually promotes the growth of juvenile white shrimp in fishmeal-reduction diets[2]. H-Met-Met-OH has been widely used as a dietary supplement to promote the growth of carp, while high doses of H-Met-Met-OH can induce a high proportion of cholestatic liver disease with fibrosis in fish [3].
References:
[1] Niu J, Lemme A, He J Y, et al. Assessing the bioavailability of the Novel Met-Met product (AQUAVI® Met-Met) compared to DL-methionine (DL-Met) in white shrimp (Litopenaeus vannamei)[J]. Aquaculture, 2018, 484: 322-332.
[2] Xie J J, Lemme A, He J Y, et al. Fishmeal levels can be successfully reduced in white shrimp (Litopenaeus vannamei) if supplemented with DL‐Methionine (DL‐Met) or DL‐Methionyl‐DL‐Methionine (Met‐Met)[J]. Aquaculture nutrition, 2018, 24(3): 1144-1152.
[3] Yin Z, Shi B, Liang X, et al. Tolerance and toxicity assessment of a novel methionine source, dipeptide Met-Met on common carp Cyprinus carpio[J]. Aquaculture, 2025, 595: 741514.