GLPBio

Gamma Secretase

Read More about this category

Gamma secretase (γ-secretase), a member of the intramembrane cleaving protease (i-CLiP) family, is a promiscuous di-aspartyl protease that catalyzes the regulated intramembrane proteolysis (RIP), in which substrate proteins are cleaved within their membrane-spanning domain. A functional γ-secretase is a multi-protein complex consisting of the catalytic component, presenilin (PSEN), and three protein cofactors, including nicastrin (NCT), anterior-pharynx defective-1 (APH1) and PSEN enhancer-2 (PEN2). So far, 90 substrates of γ-secretase have been identified, which are type-I transmembrane proteins, except for glutamate receptor GluR3, polycystin-1 and glucosaminyltransferase (GnT-V), and appear to function as signaling proteins regulating a wide variety of cellular events, such as Notch signaling pathway.

Products Related to Gamma Secretase(42)

  • GC10064 structure
    GC10064Flurizan
    CAS: 51543-40-9
    Purity: >99.50%

    A COX-inactive enantiomer of flurbiprofen

  • GC10998 structure
    GC10998PF-03084014
    CAS: 865773-15-5
    Purity: >98%

    γ-secretase inhibitor

  • GC12096 structure
    GC12096Semagacestat (LY450139)
    CAS: 425386-60-3
    Purity: >99.50%

    A pan γ-secretase inhibitor

  • GC12191 structure
    GC12191LY-411575
    CAS: 209984-57-6
    Purity: >98.00%

    A γ-secretase inhibitor

  • GC12653 structure
    GC12653LY3039478
    CAS: 1421438-81-4
    Purity: >98.00%

    A Notch inhibitor

  • GC12659 structure
    GC12659Begacestat
    CAS: 769169-27-9
    Purity: >99.50%

    An inhibitor of γ-secretase

  • GC12942 structure
    GC12942DAPT (GSI-IX)
    CAS: 208255-80-5
    Purity: >98.00%

    DAPT (GSI-IX) es un inhibidor de γ-secretase oralmente activo con IC50s de 115 nM y 200 nM para el amiloide total de β (Aβ) y Aβ42 producidos en cultivos neuronales primarios humanos, respectivamente.

  • GC13099 structure
    GC13099BMS 299897
    CAS: 290315-45-6
    Purity: >98.50%

    A γ-secretase inhibitor

  • GC13619 structure
    GC13619JLK 6
    CAS: 62252-26-0
    Purity: >98%

    A protease inhibitor

  • GC13673 structure
    GC13673BMS-708163 (Avagacestat)
    CAS: 1146699-66-2
    Purity: >98.00%

    A potent inhibitor of γ-secretase

  • GC15059 structure
    GC15059Sulindac sulfide
    CAS: 49627-27-2
    Purity: >99.00%

    El sulfuro de sulindac es un inhibidor no competitivo de la γ-secretasa, con una IC50 de 20,2 μM para la actividad de la γ42-secretasa.

  • GC15364 structure
    GC15364L-685,458
    CAS: 292632-98-5
    Purity: >99.00%

    A γ-secretase inhibitor

  • GC15645 structure
    GC15645Compound W
    CAS: 173550-33-9
    Purity: >98%

    A Notch1 signaling modulator

  • GC15896 structure
    GC15896Z-Ile-Leu-aldehyde
    CAS: 161710-10-7
    Purity: >98.00%

    Z-Ile-Leu-aldehÍdo (Z-IL-CHO) es un inhibidor de aldehÍdo peptÍdico potente y competitivo de γ-secretasa y muesca.

  • GC15899 structure
    GC15899MK-0752
    CAS: 471905-41-6
    Purity: >98.00%

    A potent inhibitor of γ-secretase

  • GC16197 structure
    GC16197RO4929097
    CAS: 847925-91-1
    Purity: >98.00%

    An inhibitor of γ-secretase

  • GC16431 structure
    GC16431MRK 560
    CAS: 677772-84-8
    Purity: >99.00%

    A potent inhibitor of γ-secretase

  • GC17671 structure
    GC17671YO-01027 (Dibenzazepine, DBZ)
    CAS: 209984-56-5
    Purity: >98.00%

    YO-01027 (Dibenzazepine, DBZ) es un inhibidor de γ-secretase, con los vaslores de IC 50 de 2.64±0.30 y 2.92±0.22nM para la escisión de APPL y Notch, respectivamente

  • GC17791 structure
    GC17791LY2811376
    CAS: 1194044-20-6
    Purity: >99.50%

    A BACE1 inhibitor

  • GC19290 structure
    GC19290PF-3084014
    CAS: 1290543-63-3
    Purity: >98.00%

    PF-3084014 (PF-3084014) es un inhibidor de la secretasa reversible, biodisponible por vÍa oral, no competitivo y selectivo con una IC50 de 6,2 nM. La inhibiciÓn de la seÑalizaciÓn de Notch por PF-3084014 al tiempo que minimiza la toxicidad gastrointestinal presenta un enfoque prometedor para la investigaciÓn de cÁnceres dependientes del receptor de Notch.

  • GC30427 structure
    GC30427ELN 318463 racemate
    CAS: 851599-82-1
    Purity: >98%

    El racemato de ELN 318463 es el racemato de ELN318463.

  • GC30887 structure
    GC30887NGP555
    CAS: 1304630-27-0
    Purity: >98.00%

    NGP555 es un modulador de γ-secretasa.

  • GC30954 structure
    GC30954Itanapraced (CHF5074)
    CAS: 749269-83-8
    Purity: >98.00%

    Itanapraced (CHF5074) (CHF5074) es un nuevo modulador de γ-secretasa, reduce la secreciÓn de Aβ42 y Aβ40, con una IC50 de 3,6 y 18,4 μM, respectivamente.

  • GC31012 structure
    GC31012BMS 433796
    CAS: 935525-13-6
    Purity: >98%

    BMS 433796 es un inhibidor de la γ-secretasa con actividad reductora de Aβ en un modelo de ratÓn transgénico de la enfermedad de Alzheimer.