2-Phenylacetophenone has broad-spectrum efflux pump inhibition activity. 2-Phenylacetophenone is a benzoin derivative used as a photoinitiator in vinyl polymerization.
2-Phenylacetophenone displays antibacterial activity against B. subtilis, M. smegmatis, and M. aurum with MICs of 500 碌g/mL[1].
2-Phenylacetophenone (1000 碌g/mL) inhibits biofilm formation for M. smegmatis[1].
[1]. Hellewell L, et al. Chalcones, stilbenes and ketones have anti-infective properties via inhibition of bacterial drug-efflux and consequential synergism with antimicrobial agents. Access Microbiol. 2020 Feb 18;2(4):acmi000105.