GLPBio

Potassium tetrachloroplatinate

Catalog No.: GD19746Purity:>98.00%
COASDSData Sheet
Potassium tetrachloroplatinate (K₂PtCl₄) is used as common starting material of the classic Pt(II) anticancer complexes such as cisplatin.

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Potassium tetrachloroplatinate
Cas No.: 10025-99-7
1gIn Stock
$73.00
1
5gIn Stock
$220.00
1
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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Descripción (Description)

Potassium tetrachloroplatinate (K₂PtCl₄) is used as common starting material of the classic Pt(II) anticancer complexes such as cisplatin [1]. Potassium tetrachloroplatinate is used as catalyst in deuteriation of benzoic acid with D2O [2].

In vitro, Potassium tetrachloroplatinate (150μM; 1h) killed about 50% EMT6 mammary tumor cell at 37℃ [3].

In vivo, Potassium tetrachloroplatinate (10mg/kg; i.p.) induced a tumor growth delay of ~3.8 days in Lewis lung carcinoma-transplanted C57BL/6J mice, and a combination treatment with hyperthermia (43°C, 30min) did not significantly enhance the antitumor effect [3].

References:
[1] Wilson, Justin J., and Stephen J. Lippard. "Synthetic methods for the preparation of platinum anticancer complexes." Chemical reviews 114.8 (2014): 4470-4495.
[2] Kańska, Marianna, and R. Kański. "Deuteriation of benzoic acid in the presence of homogeneous potassium tetrachloroplatinate (II) catalyst." Journal of radioanalytical and nuclear chemistry 162.1 (1992): 179-186.
[3] Herman, Terence S., et al. "Effect of hyperthermia on the action of cis-diamminedichloroplatinum (ii), rhodamine 1232 [tetrachloroplatinum (ii)], rhodamine 123, and potassium tetrachloroplatinate in vitro and in vivo." Cancer research 48.9 (1988): 2335-2341.

Protocolo (Protocol)

Cell experiment [1]:

Cell lines

EMT6 mammary tumor cell line

Preparation Method

EMT6 cells were placed into T-25 flasks. Potassium tetrachloroplatinate in a small volume of sterile 0.9% phosphate-buffered saline were added to the cells in complete medium in concentrations ranging from 1 to 500μM. For hyperthermia, flasks were horizontally submersed in a Plexiglas water tank with a continuous inflow and outflow system controlled by a water temperature controller. After exposure to the agent for 1h at 37℃, 42℃, or 43℃, the cells were washed twice with saline, suspended by trypsinization, and diluted in complete growth medium and survival was measured by colony formation. The colonies were visualized by staining with crystal violet in methanol containing 2% formaldehyde. The colonies were counted manually.

Reaction Conditions

1-500μM; 1h

Applications

50% of the EMT6 were killed by about 150μM Potassium tetrachloroplatinate. At 42°C there was about a 0.4-decade enhancement in cell killing for 500μM of Potassium tetrachloroplatinate, and at 43°C there was about a 1.5-decade enhancement in cell killing at 500μM as compared to the cell killing seen at 37°C.
Animal experiment [1]:

Animal models

Lewis lung carcinoma bared male C57BL/6J mice

Preparation Method

Potassium tetrachloroplatinate was administered intraperitoneally (i.p.) immediately prior to local hyperthermia treatment. Then immerse the tumor-bearing leg in a water bath maintained at 43°C for 30 or 60 minutes for hyperthermia apply.

Dosage form

10mg/kg; i.p.

Applications

Potassium tetrachloroplatinate induced a tumor growth delay of ~3.8 days in Lewis lung carcinoma bared C57BL/6J mice, and a combination treatment with hyperthermia (43°C, 30min) did not significantly enhance the antitumor effect.

References:
[1]. Herman, Terence S., et al. "Effect of hyperthermia on the action of cis-diamminedichloroplatinum (ii), rhodamine 1232 [tetrachloroplatinum (ii)], rhodamine 123, and potassium tetrachloroplatinate in vitro and in vivo." Cancer research 48.9 (1988): 2335-2341.

Documentos del producto (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

N.º CAS
10025-99-7
Fórmula molecular
Cl4K2Pt
Peso molecular
415.087
Almacenamiento
Store at 2-8°C, protect from light,stored under nitrogen
Consejos generales
Seleccione un disolvente adecuado según los datos de solubilidad del producto. Una vez preparada, divida la solución madre en alícuotas para evitar ciclos repetidos de congelación y descongelación.
Utilice las soluciones madre en un plazo de 6 meses si se conservan a -80°C, o de 1 mes si se conservan a -20°C.
Para mejorar la solubilidad, caliente el tubo a 37°C y soníquelo durante un periodo adecuado.
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

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