Formoterol
Catalog No.: GF11341Purity:>98.00%
Formoterol is a kind of long-acting β2-adrenergic receptor (β2AR) agonist.
Los productos son exclusivamente para uso en investigación. No aptos para uso humano. No vendemos a pacientes.
Cas No.: 73573-87-2
10mM (in 1mL DMSO)In Stock
$31.00
1
5mgIn Stock
$28.00
1
10mgIn Stock
$48.00
1
25mgIn Stock
$88.00
1
50mgIn Stock
$144.00
1
100mgIn Stock
$243.00
1
200mgIn Stock
$384.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 10mM (in 1mL DMSO) | $31.00 | In Stock | 1 | |
| 5mg | $28.00 | In Stock | 1 | |
| 10mg | $48.00 | In Stock | 1 | |
| 25mg | $88.00 | In Stock | 1 | |
| 50mg | $144.00 | In Stock | 1 | |
| 100mg | $243.00 | In Stock | 1 | |
| 200mg | $384.00 | In Stock | 1 |
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com
Citas (Citations)
1 publicationsPublicaciones de investigadores que utilizan este productoDescripción (Description)
Formoterol is a kind of long-acting β2-adrenergic receptor (β2AR) agonist [1]. Formoterol is widely used for symptomatic relief in asthma and control of chronic obstructive pulmonary disease (COPD) [2]. The therapeutic mechanism of Formoterol involves both bronchodilation through airway smooth muscle relaxation and anti-inflammatory activity [2].
Formoterol (0.1μM; 24h) inhibited secretion of TNFα in the bronchial epithelial (BE) cells infected with rhinovirus [3]. Formoterol (1μM; 24h) effectively reduced tert-butyl hydroperoxide-induced SH-SY5Y cell death [1]. Formoterol (0.1nM~1μM; 24h) inhibited the IgE-dependent release of histamine from human lung mast cells in a concentration-dependent manner [4].
Formoterol (1mg/kg; 4 weeks; s.c.) decreased the expression of Fbxo32 and Trim63 in muscle wasting Balb/c mice induced by doxorubicin hydrochloride [5]. Formoterol (1mg/kg; 2 weeks; i.p.) prevented abdominal aortic aneurysm formation in erythropoietin-induced ApoE−/− mice [2].
References:
[1] Chang J C, Chang H S, Chao Y C, et al. Formoterol acting via β2-adrenoreceptor restores mitochondrial dysfunction caused by parkinson's disease-related UQCRC1 mutation and improves mitochondrial homeostasis including dynamic and transport [J]. Biology, 2024, 13(4): 231.
[2] Zhang J, Cao Y, Ren R, et al. Medium-dose formoterol attenuated abdominal aortic aneurysm induced by EPO via β2AR/cAMP/SIRT1 pathway [J]. Advanced science, 2024, 11(15): e2306232.
[3] Bochkov Y A, Busse W W, Brockman-Schneider R A, et al. Budesonide and formoterol effects on rhinovirus replication and epithelial cell cytokine responses [J]. Respiratory research, 2013, 14(1): 98.
[4] Scola A M, Chong L K, Suvarna S K, et al. Desensitisation of mast cell beta2-adrenoceptor-mediated responses by salmeterol and formoterol [J]. British journal of pharmacology, 2004, 141(1): 163-171.
[5] De Lima Junior E A, Teixeira A A S, Silveira L S, et al. Formoterol reduces muscle wasting in mice undergoing doxorubicin chemotherapy [J]. Frontiers in oncology, 2023, 13: 1237709.
Protocolo (Protocol)
| Cell experiment [1]: | |
Cell lines | Bronchial epithelial (BE) cells |
Preparation Method | BE cells were obtained from airway brushings. Cells were incubated for 24h with Formoterol (0.01% DMSO drug vehicle), and then infected with 0.25 mL of rhinovirus-16 (5×106 plaque forming units [PFU]/mL). After 24h, cytokine secretion (TNFα) was analyzed. |
Reaction Conditions | 0.1μM; 24h |
Applications | Formoterol inhibited secretion of TNFα in the cells. |
| Animal experiment [2]: | |
Animal models | Male Balb/c mice |
Preparation Method | The mice received doxorubicin hydrochloride (DOX) to induce muscle wasting. One of the groups treated with Formoterol, and another not submitted to Formoterol treatment received saline solution (0.9%) by the corresponding route of administration. The mice were euthanized for sample collection after 4 weeks. |
Dosage form | 1mg/kg; 4 weeks; s.c. |
Applications | Formoterol protected against DOX-induced increase in Fbxo32 and Trim63 gene expression. |
References: | |
Documentos del producto (Product Documents)
Purity:>98.00%Appearance:A solid
Propiedades químicas (Chemical Properties)
N.º CAS
73573-87-2
Fórmula molecular
C19H24N2O4
Peso molecular
344.4
Solubilidad
DMSO : 250 mg/mL (725.90 mM; Need ultrasonic)
Almacenamiento
-20°C
Consejos generales
Seleccione un disolvente adecuado según los datos de solubilidad del producto. Una vez preparada, divida la solución madre en alícuotas para evitar ciclos repetidos de congelación y descongelación.
Utilice las soluciones madre en un plazo de 6 meses si se conservan a -80°C, o de 1 mes si se conservan a -20°C.
Para mejorar la solubilidad, caliente el tubo a 37°C y soníquelo durante un periodo adecuado.
Utilice las soluciones madre en un plazo de 6 meses si se conservan a -80°C, o de 1 mes si se conservan a -20°C.
Para mejorar la solubilidad, caliente el tubo a 37°C y soníquelo durante un periodo adecuado.
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.
Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad
g/mol
Reviews
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