GLPBio

Glucose-dependent Insulinotropic Polypeptide (1-42) (porcine) (trifluoroacetate salt)

Catalog No.: GC92133Purity:>98.00%Synonyms: Gastric Inhibitory Peptide (1-42); GIP (1-42)
COASDSData Sheet
Glucose-dependent Insulinotropic Polypeptide (1-42) (porcine) (trifluoroacetate salt) es una hormona incretina peptídica endógena de 42 aminoácidos que induce la secreción de insulina.

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Glucose-dependent Insulinotropic Polypeptide (1-42) (porcine) (trifluoroacetate salt)
1 mgIn Stock
$84.00
1
5 mgIn Stock
$312.00
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10 mgIn Stock
$581.00
1
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Citas (Citations)

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    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Descripción (Description)

Glucose-dependent Insulinotropic Polypeptide (GIP) (1-42) is an endogenous 42-amino acid peptide incretin hormone that induces insulin secretion.1,2 It is expressed in intestinal neuroendocrine K cells and the submandibular gland and is released into circulation postprandially. GIP (1-42) inhibits histamine, pentagastrin, and insulin-induced gastric acid and pepsin secretion, increases glucose-induced insulin release, and stimulates gastric emptying in rats.3

References:
[1]. Fehmann, H.-C., and G?ke, B.Characterization of GIP(1-30) and GIP(1-42) as stimulators of proinsulin gene transcriptionPeptides16(6)1149-1152(1995).
[2]. Siskos, A.P., Katsila, T., Balafas, E., et al.Simultaneous absolute quantification of the glucose-dependent insulinotropic polypeptides GIP1-42 and GIP3-42 in mouse plasma by LC/ESI-MS/MS: Preclinical evaluation of DP-IV inhibitorsJ. Proteome Res.8(7)3487-3496(2009).
[3]. Rossowski, W.J., Zacharia, S., Mungan, Z., et al.Reduced gastric acid inhibitory effect of a pGIP(1-30)NH2 fragment with potent pancreatic amylase inhibitory activityRegul. Pept.39(1)9-17(1992).

Documentos del producto (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

Sinónimos
Gastric Inhibitory Peptide (1-42); GIP (1-42)
Nombre químico
L-tyrosyl-L-alanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-isoleucyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-L-alanyl-L-methionyl-L-α-aspartyl-L-lysyl-L-isoleucyl-L-arginyl-L-glutaminyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysylglycyl-L-lysyl-L-lysyl-L-seryl-L-α-aspartyl-L-tryptophyl-L-lysyl-L-histidyl-L-asparaginyl-L-isoleucyl-L-threonylL-tyrosyl-L-alanyl-L-α-glutamylglycyl-L-threonyl-L-phenylalanyl-L-isoleucyl-L-seryl-L-α-aspartyl-L-tyrosyl-L-seryl-L-isoleucyl-L-alanyl-L-methionyl-L-α-aspartyl-L-lysyl-L-isoleucyl-L-arginyl-L-glutaminyl-L-glutaminyl-L-α-aspartyl-L-phenylalanyl-L-valyl-L-asparaginyl-L-tryptophyl-L-leucyl-L-leucyl-L-alanyl-L-glutaminyl-L-lysylglycyl-L-lysyl-L-lysyl-L-seryl-L-α-aspartyl-L-tryptophyl-L-lysyl-L-histidyl-L-asparaginyl-L-isoleucyl-L-threonyl-L-glutamine, trifluoroacetate salt
SMILES
O=C(N[C@H](C(N[C@@H](CCC(O)=O)C(NCC(N[C@]([C@H](O)C)([H])C(N[C@H](C(N[C@@](C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC1=CC=C(O)C=C1)C(N[C@@H](CO)C(N[C@@](C(N[C@H](C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCCN[H])C(N[C@@](C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC(N)=O)C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](C(C)C)C(N[C@@H](CC(N)=O)C(N[C@@H](CC2=CNC3=C2C=CC=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CCC(N)=O)C(N[C@@H](CCCCN[H])C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CO)C(N[C@@H](CC(O)=O)C(N[C@@H](CC4=CNC5=C4C=CC=C5)C(N[C@@H](CCCCN[H])C(N[C@@H](CC6=CNC=N6)C(N[C@@H](CC(N)=O)C(N[C@@](C(N[C@]([C@H](O)C)([H])C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)C)=O)CC(C)C)=O)CC(C)C)=O)=O)=O)=O)CC7=CC=CC=C7)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)C)=O)([H])[C@@H](C)CC)=O)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)CC8=CC=CC=C8)=O)=O)=O)=O)C)[C@H](CC9=CC=C(O)C=C9)N[H].OC(C(F)(F)F)=O
Fórmula molecular
C225H342N60O66S ? XCF3COOH
Peso molecular
4975.6
Solubilidad
Water: Soluble
Almacenamiento
-20°C
Consejos generales
Seleccione un disolvente adecuado según los datos de solubilidad del producto. Una vez preparada, divida la solución madre en alícuotas para evitar ciclos repetidos de congelación y descongelación.
Utilice las soluciones madre en un plazo de 6 meses si se conservan a -80°C, o de 1 mes si se conservan a -20°C.
Para mejorar la solubilidad, caliente el tubo a 37°C y soníquelo durante un periodo adecuado.
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

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