LY3972406 hydrochloride is a kv1.3 potassium channel inhibitor without affecting hERG channel activity. LY3972406 hydrochloride hydrochloride can be used in research of immune-related diseases such as psoriasis, rheumatoid arthritis, and systemic lupus erythematosus [1].
In Vitro, LY3972406 (Compound I) hydrochloride inhibits the activity of the Kv1.3 potassium channel without blocking the hERG channel, resulting in reduced cardiotoxicity risk, enhanced ion channel selectivity, improved pharmacokinetic properties, and increased solubility[1].
References:
[1]. Coates DA, et al., Solid forms of a kv1.3 potassium shaker channel blockers and method of using the same. WO2025029769
In Vitro, LY3972406 (Compound I) hydrochloride inhibits the activity of the Kv1.3 potassium channel without blocking the hERG channel, resulting in reduced cardiotoxicity risk, enhanced ion channel selectivity, improved pharmacokinetic properties, and increased solubility[1].
References:
[1]. Coates DA, et al., Solid forms of a kv1.3 potassium shaker channel blockers and method of using the same. WO2025029769