GLPBio

m-APTA

Catalog No.: GC83458Purity:>99.50%Synonyms: 5′-S-(3-Aminophenyl)-5′-thioadenosine
COASDSData Sheet
m-APTA (5'-S-(3-aminophenyl)-5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase ( MTAP ).

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m-APTA
Cas No.: 86072-47-1
10mM (in 1mL DMSO)In Stock
$73.00
1
5mgIn Stock
$67.00
1
10mgIn Stock
$100.00
1
25mgIn Stock
$200.00
1
50mgIn Stock
$300.00
1
100mgIn Stock
$450.00
1
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Citas (Citations)

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    Nature
    641, 529–536 (2025)
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    628, 630–638 (2024)
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    632, 686–694 (2024)
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    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
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    Cell
    187(9):2288-2304 (2024)
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    Cell
    183(7):1867-1883 (2020)
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    388(6745) (2025)
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    387(6739) (2025)
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    387(6734) (2025)
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    35, 97–116 (2025)
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    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    31, 1291–1307 (2021)

Descripción (Description)

m-APTA (5'-S-(3-aminophenyl)-5'-thioadenosine) is a selective chemoprotective agent targeting methylthioadenosine phosphorylase ( MTAP ). m-APTA can be converted into adenine, which is a crucial step in protecting normal cells from the toxicity of nucleobase analogues (NBA). m-APTA is promising for research of MTAP-deficient cancers [1].

References:
[1]. Zhang S, et al. 5'-S-(3-aminophenyl)-5'-thioadenosine, a novel chemoprotective agent for reducing toxic side effects of fluorouracil in treatment of MTAP-deficient cancers. Mol Cancer Ther. 2025 Mar 10.

Documentos del producto (Product Documents)

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

N.º CAS
86072-47-1
Sinónimos
5′-S-(3-Aminophenyl)-5′-thioadenosine
Fórmula molecular
C16H18N6O3S
Peso molecular
374.42
Solubilidad
DMSO: 100 mg/mL (267.08 mM; Need ultrasonic)
Almacenamiento
Store at -20°C
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

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