Neocrocin B is a carotenoid crocin. Neocrocin B inhibits L-Glutamic acid -induced neuronal cell damage in a dose-dependent manner. Neocrocin B can be used in studies related to neuronal injury [1].
In Vitro, Neocrocin B (0.1-10 μM; 24 h) exhibits minimal neuroprotective activity against H2O2-induced injury in SH-SY5Y human neuroblastoma cells, with a maximum protection rate of 10.39 ± 4.85 at 10 μM[1]. Neocrocin B (0.1-10 μM; 24 h) exhibits dose-dependent neuroprotective activity against L-glutamic acid-induced injury in SH-SY5Y human neuroblastoma cells, with a maximum protection rate of 40.03 ± 3.91 at 10 μM[1].
References:
[1]. Ni Y, et al. Discovery and LC-MS Characterization of New Crocins in Gardeniae Fructus and Their Neuroprotective Potential. J Agric Food Chem. 2017;65(14):2936-2946.
In Vitro, Neocrocin B (0.1-10 μM; 24 h) exhibits minimal neuroprotective activity against H2O2-induced injury in SH-SY5Y human neuroblastoma cells, with a maximum protection rate of 10.39 ± 4.85 at 10 μM[1]. Neocrocin B (0.1-10 μM; 24 h) exhibits dose-dependent neuroprotective activity against L-glutamic acid-induced injury in SH-SY5Y human neuroblastoma cells, with a maximum protection rate of 40.03 ± 3.91 at 10 μM[1].
References:
[1]. Ni Y, et al. Discovery and LC-MS Characterization of New Crocins in Gardeniae Fructus and Their Neuroprotective Potential. J Agric Food Chem. 2017;65(14):2936-2946.