Nucleic Acid Turnover/Signaling

Akt1, 2, and 3 are serine/threonine protein kinases in the phosphatidylinositol 3 (PI3)-kinase signalling pathway that play a critical role in the regulation of cell proliferation and survival.

8-Nitroguanine is a nitrative guanine derivative formed by oxidative damage to the guanine base in DNA by reactive nitrogen species (RNS) during inflammation and in vitro by reaction of DNA with peroxynitrite and other RNS reagents.

MST-312 resulta en un potente inhibidor de la telomerasa, con un valor de IC 50 de 0.67μM.

β-Amanitin es una toxina peptÍdica cÍclica en el hongo venenoso Amanita phalloides. β-La amanitina inhibe la ARN polimerasa II y III de eucariotas. β-Amanitin inhibe la sÍntesis de proteÍnas. β-La amanitina se puede utilizar como componente citotÓxico de los conjugados anticuerpo-fÁrmaco (ADC).

Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S.

Ciprofloxacin-d8 is intended for use as an internal standard for the quantification of ciprofloxacin by GC- or LC-MS.

Tigecycline-d9 is intended for use as an internal standard for the quantification of tigecycline by GC- or LC-MS.

Dihydroresveratrol is a major metabolite of resveratrol that is produced by animal-associated bacteria, including the gut microbiota.

La 6-aminofenantridina inhibe la actividad de plegamiento de proteÍnas del ribosoma (PFAR).

La (R)-giramida A (clorhidrato) es un inhibidor de la girasa del ADN bacteriano que interrumpe la actividad de superenrollamiento con un valor IC50 de 3,3 µM.

5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS.

Xanthine oxidase (XO) generates reactive oxygen species, including hydrogen peroxide (H2O2), as it oxidizes specific substrates in the presence of water and oxygen.

9-Deazaguanine is a purine nucleoside analog with oral activity, functioning as a potent inhibitor of purine nucleoside phosphorylase (PNP).

La ametantrona (NSC 196473) es un agente antitumoral que se intercala en el ADN e induce la ruptura del ADN mediada por la topoisomerasa II (TOP2).

Pemetrexed (hidrato de sal de sodio) es un nuevo antifolato, los valores Ki del pentaglutamato de LY231514 son 1,3, 7,2 y 65 nM para inhibir la timidilato sintasa (TS), la dihidrofolato reductasa (DHFR) y la glicinamida ribonucleÓtido formiltransferasa (GARFT), respectivamente .

Trimethoprim is an antibiotic that inhibits dihydrofolate reductase (DHFR) and shows selectivity for bacterial DHFR over mammalian DHFR (IC50s = 5 and 30,000 nM, respectively).

An internal standard for quantifying doxycycline

An internal standard for the quantification of docosanoic acid

A neuropeptide with diverse biological activities

A neuropeptide with diverse biological activities

A protein synthesis inhibitor with diverse biological activities

A cGAS inhibitor

A cGAS inhibitor

A neuropeptide with diverse biological activities