Pemetrexed (sodium salt hydrate) |
| Catalog No.GC44591 |
Pemetrexed (hidrato de sal de sodio) es un nuevo antifolato, los valores Ki del pentaglutamato de LY231514 son 1,3, 7,2 y 65 nM para inhibir la timidilato sintasa (TS), la dihidrofolato reductasa (DHFR) y la glicinamida ribonucleÓtido formiltransferasa (GARFT), respectivamente .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 357166-29-1
Sample solution is provided at 25 µL, 10mM.
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Pemetrexed is pyrrotopyrimidine-based, multi-targeted antifolate with broad in vivo antitumor activity. Originally identified as a highly efficient substrate for folylpolyglutamate synthase, pemetrexed potently inhibits multiple folate-dependent enzymes involved in both purine and pyrimidine synthesis including thymidylate synthase (Ki = 109 nM), dihydrofolate reductase (Ki = 7 nM), glycinamide ribonucleotide formyltransferase (Ki = 9.3 μM), and aminoimidazole carboxamide ribonucleotide formyltransferase (Ki = 3.6 μM). Its antiproliferative activity has been demonstrated in a wide variety of solid tumors, including non-small cell lung, breast, mesothelioma, colorectal, pancreatic, gastric, bladder, cervix, and head and neck.
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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