Oxindolylalanine, a tryptophan analogue, is an inhibitor of tryptophan indole-lyase (K i: 5 μM) and tryptophan synthase. Tryptophan indole-lyase is a bacterial enzyme which catalyzes the reversible formation of indole and ammonium pyruvate from L-tryptophan.
References:
[1]. Phillips RS, Buisman AA, Choi S, Hussaini A, Wood ZA. The crystal structure of Proteus vulgaris tryptophan indole-lyase complexed with oxindolyl-L-alanine: implications for the reaction mechanism. Acta Crystallogr D Struct Biol. 2018;74(Pt 8):748-759.
[2]. Phillips RS, Harris AP. Structural Basis of the Stereochemistry of Inhibition of Tryptophan Synthase by Tryptophan and Derivatives. Biochemistry. 2021;60(3):231-244.
References:
[1]. Phillips RS, Buisman AA, Choi S, Hussaini A, Wood ZA. The crystal structure of Proteus vulgaris tryptophan indole-lyase complexed with oxindolyl-L-alanine: implications for the reaction mechanism. Acta Crystallogr D Struct Biol. 2018;74(Pt 8):748-759.
[2]. Phillips RS, Harris AP. Structural Basis of the Stereochemistry of Inhibition of Tryptophan Synthase by Tryptophan and Derivatives. Biochemistry. 2021;60(3):231-244.