Pomalidomide-PEG1-C2-N3 (Synonyms: Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50) |
Catalog No.GC61200
One-Click Copy Product Info
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Pomalidomida-PEG1-C2-N3 es un conjugado ligando-enlazador de ligasa E3 sintetizado que incorpora el ligando cereblon basado en pomalidomida y el enlazador PEG de 1 unidad utilizado en la tecnologÍa PROTAC. Pomalidomida-PEG1-C2-N3 se puede utilizar para diseÑar un degradador selectivo CDK6 PROTAC CP-10. CP-10 induce la degradaciÓn de CDK6 con un DC50 de 2,1 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2271036-44-1
Sample solution is provided at 25 µL, 10mM.
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Pomalidomide-PEG1-C2-N3 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 1-unit PEG linker used in PROTAC technology. Pomalidomide-PEG1-C2-N3 can be used to design a selective CDK6 PROTAC degrader CP-10. CP-10 induces the degradation of CDK6 with an DC50 of 2.1 nM[1].
[1]. Su S, et al. Potent and Preferential Degradation of CDK6 via Proteolysis Targeting Chimera Degraders. J Med Chem. 2019 Aug 2.
| Cas No. | 2271036-44-1 | SDF | |
| Sinónimos | Cereblon Ligand-Linker Conjugates 13; E3 ligase Ligand-Linker Conjugates 50 | ||
| Canonical SMILES | O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCN=[N+]=[N-])=O | ||
| Formula | C17H18N6O5 | M.Wt | 386.36 |
| Solubility | Storage | -20°C, stored under nitrogen | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.5883 mL | 12.9413 mL | 25.8826 mL |
| 5 mM | 517.7 μL | 2.5883 mL | 5.1765 mL |
| 10 mM | 258.8 μL | 1.2941 mL | 2.5883 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 27 reference(s) in Google Scholar.)