GLPBio

Serotonin Transporter

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Serotonin Transporters (SERTs) are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.

Serotonin transporter (SERT) regulates extracellular levels of serotonin (5-hydroxytryptamine, 5HT) in the brain by transporting 5HT into neurons and glial cells. The human SERT (hSERT) is the primary target for drugs used in the treatment of emotional disorders, including depression. hSERT belongs to the solute carrier 6 family that includes a bacterial leucine transporter (LeuT), for which a high resolution crystal structure has become available.

Products Related to Serotonin Transporter(61)

  • GC60394 structure
    GC60394(±)-Duloxetine hydrochloride
    CAS: 947316-47-4
    Purity: >99.50%

    El clorhidrato de (±)-duloxetina ((Rac)-duloxetina) es el racemato del clorhidrato de duloxetina.

  • GC60424 structure
    GC60424(S)-Venlafaxine
    CAS: 93413-44-6
    Purity: >98%

    (S)-venlafaxina es la configuraciÓn (S) de venlafaxina. La venlafaxina es un potente inhibidor dual de la recaptaciÓn de serotonina (5-HT)/norepinefrina (NE), activo por vÍa oral. La venlafaxina es un agente antidepresivo.

  • GC60740 structure
    GC60740Dapoxetine-D7 hydrochloride
    CAS: 129938-20-1
    Purity: >99.50%

    El clorhidrato de dapoxetina-d7 (LY-210448-d7) es el clorhidrato de dapoxetina marcado con deuterio.

  • GC65014 structure
    GC65014DSP-1053
    CAS: 1176326-76-3
    Purity: >99.00%

    DSP-1053, un derivado de bencilpiperidina, es un potente inhibidor del transportador de serotonina (SERT) con una Ki de 1,02 nM.

  • GC65209 structure
    GC65209Imipramine-d4 hydrochloride
    CAS: 61361-33-9
    Purity: >99.50%
  • GC69880 structure
    GC69880SERT-IN-2
    CAS: 2055228-33-4
    Purity: >98.00%

    SERT-IN-2 es un potente inhibidor de SERT (IC50=0.58 nM) con actividad antidepresiva. Tiene una buena biodisponibilidad, con un F(%) del 83.28% en ratas. SERT-IN-2 puede atravesar la barrera hematoencefálica.

  • GC70178 structure
    GC70178ZZL-7
    CAS: 99141-91-0
    Purity: >98.00%

    ZZL-7 es un antidepresivo de acción rápida. ZZL-7 actúa mediante la interrupción de la interacción entre el transportador de serotonina (SERT) y la óxido nítrico sintasa neuronal (nNOS) en el núcleo dorsal del rafe (DRN). ZZL-7 puede atravesar fácilmente la barrera hematoencefálica y se utiliza en investigaciones sobre depresión mayor severa (MDD).

  • GC70271 structure
    GC70271Ampreloxetine hydrochloride
    CAS: 1227056-87-2
    Purity: >99.00%

    Ampreloxetine (TD-9855) hydrochloride is an orally active and CNS-penetrant inhibitor of Norepinephrine transporter (NET) and Serotonin 5-HT uptake transporter (SERT), but not Dopamine transporter (DAT).

  • GC71618 structure
    GC71618rel-Sertraline-d3 hydrochloride
    CAS: 1330180-66-9

    rel-Sertraline-d3 hydrochloride es el deuterio marcado clorhidrde sertralina.

  • GC71620 structure
    GC71620Venlafaxine-d6
    CAS: 1020720-02-8

    Venlafaxine-d6 es el deuterio etiquetado como venlafaxina.

  • GC79505 structure
    GC79505RPI-GLYT2-82
    Purity: >99.00%

    RPI-GLYT2-82 is a reversible, blood-brain barrier-permeable allosteric inhibitor of GlyT2 with an IC 50 value of 554 nM.

  • GC79780 structure
    GC79780SERT/5-HT-IN-1
    CAS: 3120534-54-2
    Purity: >99.00%

    SERT/5-HT-IN-1 (compound D17) is an orally active and potent dual target inhibitor of SERT/5-HT3A ( SERT IC 50 = 1.5 nM, NET IC 50 = 49 nM, DAT IC 50 = 91 nM, 5-HT3A K i = 12 nM).

  • GC79790 structure
    GC79790A6CDQ
    CAS: 1005550-46-8
    Purity: >98%

    A6CDQ is a human organic cation transporter ( hOCT ) inhibitor with antidepressant-like activity that can cross the blood-brain barrier.