JAK
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Janus kinases (JAKs), belonging to a distinct family of tyrosine kinases, are non-receptor tyrosine kinases that transduce signals of cytokine receptors via diverse signal transduction pathways. Mammalian JAK family consists of four structurally similar members, JAK1, JAK2, JAK3 and Tyrosine kinase 2 (TYK2), which are characterized by containing seven JAK homology (JH) domains. The presence of JH1 and JH2 domains is the most intriguing feature of JAK proteins. JH1 domain is the main catalytic domain; while JH2 is usually considered as a catalytically inactive pseudokinase domain. However, results of recent studies have shown that JH2 acts as a dual-specificity protein kinase to phosphorylate two regulatory sites (Ser523 and Tyr570) in JAK2.
Products Related to JAK(190)
- GC72815Itacnosertib (hydrocholide)CAS: 2409543-84-4Purity: >99.00%
Itacnosertib (hydrocholide) es un inhibidor de JAK2, ACVR1 ALK2 y ALK5.
- GC73139SJ1008030 formicPurity: >97.00%
SJ1008030 formic es un PROTAC JAK2 que degrada selectivamente a JAK2.
- GC73456JAK1-IN-11CAS: 2427608-43-1Purity: >98.00%
JAK1-IN-11 (compuesto 11) es un potente inhibidor de JAK, con IC50 de 0,02 nM (JAK1), y 0,44 nM (JAK2), respectivamente.
- GC73600JAK3-IN-14CAS: 454234-24-3Purity: >99.00%
JAK3-IN-14 (compuesto 1) es un potente inhibidor de JAK3, con valores de IC50 de 38 y 600 nM para JAK3 y JAK2, respectivamente.
- GC73627HDAC/JAK/BRD4-IN-1CAS: 2755325-84-7Purity: >95.00%
HDAC/JAK/BRD4-IN-1(compuesto 25ap) es un potente inhibidor triple HDAC/JAK/BRD4.
- GC79003WCY-8-67 TFAPurity: >99.00%
WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM.
- GC79070WWQ-03-012CAS: 3076807-15-0Purity: >98.00%
WWQ-03-012 is a selective DESI2 inhibitor with an IC 50 of 47.3 nM.
- GC80468Peficitinib-d 3Purity: >98.00%
Peficitinib -d 3 (ASP015K-d 3 ) is the deuterium labeled Peficitinib.
- GC80946PROTAC JAK1/2 degrader-1Purity: >99.00%
PROTAC JAK1/2 degrader-1 is an orally active JAK1 / JAK2 PROTAC degrader, with DC 50 values of 1.4 μM and 0.92 μM against JAK1 and JAK2, respectively.
- GC80947JAK1/2 ligand 1CAS: 1026028-96-5Purity: >99.50%
JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1.
- GC81026PROTAC SKP2 Degrader-1CAS: 3120650-15-6Purity: >99.50%
PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC72815 | Itacnosertib (hydrocholide) | 2409543-84-4 | >99.00% | |
Itacnosertib (hydrocholide) es un inhibidor de JAK2, ACVR1 ALK2 y ALK5. | ||||
| GC73139 | SJ1008030 formic | - | >97.00% | |
SJ1008030 formic es un PROTAC JAK2 que degrada selectivamente a JAK2. | ||||
| GC73148 | JAK-IN-21 | 2445499-20-5 | >99.00% | |
JAK-IN-21 (ejemplo 4) es un inhibidor selectivo y potente de JAK con IC50s de 1,73, 2,04, 109 y 62,9 nM contra JAK1, JAK2, J2V617F y TYK2, respectivamente. | ||||
| GC73369 | SJ988497 | 2595365-41-4 | >98.00% | |
SJ988497 es un degrader PROTAC JAK2. | ||||
| GC73456 | JAK1-IN-11 | 2427608-43-1 | >98.00% | |
JAK1-IN-11 (compuesto 11) es un potente inhibidor de JAK, con IC50 de 0,02 nM (JAK1), y 0,44 nM (JAK2), respectivamente. | ||||
| GC73475 | JAK-IN-26 | 2417134-93-9 | >98.00% | |
JAK-IN-26 (compuesto 2) es un inhibidor de JAK activo por vía oral con buenas características farmacocinéticas. | ||||
| GC73600 | JAK3-IN-14 | 454234-24-3 | >99.00% | |
JAK3-IN-14 (compuesto 1) es un potente inhibidor de JAK3, con valores de IC50 de 38 y 600 nM para JAK3 y JAK2, respectivamente. | ||||
| GC73627 | HDAC/JAK/BRD4-IN-1 | 2755325-84-7 | >95.00% | |
HDAC/JAK/BRD4-IN-1(compuesto 25ap) es un potente inhibidor triple HDAC/JAK/BRD4. | ||||
| GC79003 | WCY-8-67 TFA | - | >99.00% | |
WCY-8-67 TFA is an orally active and selective USP5 inhibitor, with an IC 50 value of 1.33 μM. | ||||
| GC79070 | WWQ-03-012 | 3076807-15-0 | >98.00% | |
WWQ-03-012 is a selective DESI2 inhibitor with an IC 50 of 47.3 nM. | ||||
| GC79181 | RAI-20 | 2549180-90-5 | >98.50% | |
RAI-20 (H018) is an orally active JAK1/JAK2 dual inhibitor ( IC 50 =15.1 and 22.7 nM). | ||||
| GC80468 | Peficitinib-d 3 | - | >98.00% | |
Peficitinib -d 3 (ASP015K-d 3 ) is the deuterium labeled Peficitinib. | ||||
| GC80946 | PROTAC JAK1/2 degrader-1 | - | >99.00% | |
PROTAC JAK1/2 degrader-1 is an orally active JAK1 / JAK2 PROTAC degrader, with DC 50 values of 1.4 μM and 0.92 μM against JAK1 and JAK2, respectively. | ||||
| GC80947 | JAK1/2 ligand 1 | 1026028-96-5 | >99.50% | |
JAK1/2 ligand 1 is a ligand for the PROTAC target protein of JAK1/2, which can be used to synthesize PROTAC JAK1/2 degrader-1. | ||||
| GC81026 | PROTAC SKP2 Degrader-1 | 3120650-15-6 | >99.50% | |
PROTAC SKP2 Degrader-1 is a PROTAC degrader targeting SKP2, with a K d value of 6.28 μM. | ||||
| GC91059 | LCC-12 (formate) | - | >98.00% | |
Un quelante de cobre (II) y un derivado de metformina. | ||||
| GC91148 | JAK Inhibitor 31 | 2891469-99-9 | >98.00% | |
Un inhibidor de JAK2 | ||||
| GC91506 | Bayer 18 | 1251752-12-1 | >98.00% | |
Bayer 18 is a tyrosine kinase 2 (TYK2) inhibitor (IC50 = 18.7 nM). | ||||
| GC91689 | TG46 | 936091-15-5 | >98.00% | |
TG46 is an inhibitor of JAK2 (IC50 = 12.5 µM). | ||||
| GN10442 | Curculigoside | 85643-19-2 | >99.50% | |
| GN10584 | Ginsenoside Rk1 | 494753-69-4 | >98.00% | |
| GN10627 | Atractylenolide I | 73069-13-3 | >98.00% | |