Reactive Oxygen Species
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Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.
ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.
Products Related to Reactive Oxygen Species(505)
- GC47436HT-2 Toxin-13C22CAS: 1486469-92-4Purity: >98.00%
An internal standard for the quantification of HT-2 toxin
- GC47439Hydralazine-d4 (hydrochloride)CAS: 2749234-32-8Purity: >99.00%
A neuropeptide with diverse biological activities
- GC47477JKE-1674CAS: 2421119-60-8Purity: >98.00%
JKE-1674 es un inhibidor de la glutatiÓn peroxidasa 4 (GPX4) activo por vÍa oral y un metabolito activo del inhibidor de GPX4 ML-210. JKE-1674, un anÁlogo de ML-210 en el que el anillo de nitroisoxazol se reemplaza con una α-nitroketoxima. JKE-1674 puede convertirse en un Óxido de nitrilo JKE-1777. JKE-1674 mata las células LOX-IMVI de una manera que es equipotente a ML-210 y es completamente rescatada por inhibidores de ferroptosis.
- GC47549L-Carnosine-d4CAS: 2714339-90-7Purity: >99.00%
A neuropeptide with diverse biological activities
- GC47659Methyl 3,4-DihydroxyphenylacetateCAS: 25379-88-8Purity: >98.00%
A polyphenol with antioxidant and antiviral activities
- GC47826Omeprazole sulfone-d3CAS: 2749628-17-7Purity: >99.00%
A neuropeptide with diverse biological activities
- GC47932Pelargonidin 3-O-glucoside (chloride)CAS: 18466-51-8Purity: >95.00%
El cloruro de calistefina (pelargonidina 3-O-glucÓsido) es una antocianina que se puede encontrar en las fresas y las chokeberries.
- GC47977PropiconazoleCAS: 60207-90-1Purity: >96.00%
Propiconazole es un triazol N-sustituido activo por vía oral con actividad antifúngica.
- GC47978Propiconazole-d3 (nitrate)CAS: 2699607-26-4Purity: >99.00%
A neuropeptide with diverse biological activities
- GC47979Propiconazole-d7CAS: 1246818-14-3Purity: >99.00%
An internal standard for the quantification of propiconazole
- GC47980Propionyl-L-carnitine-d3 (chloride)CAS: 1334532-19-2Purity: >99.00%
An internal standard for the quantification of propionyl-L-carnitine
- GC48019Quercetin (hydrate)CAS: 849061-97-8Purity: >96.00%
Quercetin (hydrate) is the dihydrate form of the flavonoid quercetin, which possesses various biological activities.
- GC48120T-2 Toxin-13C24CAS: 21259-20-1Purity: >98.00%
A neuropeptide with diverse biological activities
- GC48162Theobromine-d6CAS: 117490-40-1Purity: >99.00%
An internal standard for the quantification of theobromine
- GC48194trans-Resveratrol-d4CAS: 1089051-56-8Purity: >99.00%
An internal standard for the quantification of trans-resveratrol
- GC48247Verrucarin ACAS: 3148-09-2Purity: ≥70.00%
La verrucarina A (muconomicina A), una micotoxina macrocÍclica de tipo D derivada del hongo patÓgeno Myrothecium verrucaria, es un inhibidor de la sÍntesis de proteÍnas. Verrucarin A inhibe el crecimiento de las lÍneas celulares de leucemia y activa las caspasas y la apoptosis y la seÑalizaciÓn inflamatoria en los macrÓfagos. Verrucarin A aumentÓ efectivamente la fosforilaciÓn de p38 MAPK y disminuyÓ la fosforilaciÓn de ERK/Akt. Verrucarin A provocÓ la desregulaciÓn del ciclo celular a través de la inducciÓn de p21 y p53.
| Catalog No. | Product Name | CAS No. | Purity | Structure |
|---|---|---|---|---|
| GC47436 | HT-2 Toxin-13C22 | 1486469-92-4 | >98.00% | |
An internal standard for the quantification of HT-2 toxin | ||||
| GC47439 | Hydralazine-d4 (hydrochloride) | 2749234-32-8 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47477 | JKE-1674 | 2421119-60-8 | >98.00% | |
JKE-1674 es un inhibidor de la glutatiÓn peroxidasa 4 (GPX4) activo por vÍa oral y un metabolito activo del inhibidor de GPX4 ML-210. JKE-1674, un anÁlogo de ML-210 en el que el anillo de nitroisoxazol se reemplaza con una α-nitroketoxima. JKE-1674 puede convertirse en un Óxido de nitrilo JKE-1777. JKE-1674 mata las células LOX-IMVI de una manera que es equipotente a ML-210 y es completamente rescatada por inhibidores de ferroptosis. | ||||
| GC47478 | JKE-1716 | 2421118-05-8 | >98.00% | |
JKE-1716 es un inhibidor de GPX4 potente y selectivo que contiene Ácido nÍtrico. | ||||
| GC47549 | L-Carnosine-d4 | 2714339-90-7 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47582 | Lupulone | 468-28-0 | >95.00% | |
La lupulona es un betaÁcido de la planta de lÚpulo H. | ||||
| GC47659 | Methyl 3,4-Dihydroxyphenylacetate | 25379-88-8 | >98.00% | |
A polyphenol with antioxidant and antiviral activities | ||||
| GC47683 | MitoB-d15 | - | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47684 | MitoP-d15 | - | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47826 | Omeprazole sulfone-d3 | 2749628-17-7 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47932 | Pelargonidin 3-O-glucoside (chloride) | 18466-51-8 | >95.00% | |
El cloruro de calistefina (pelargonidina 3-O-glucÓsido) es una antocianina que se puede encontrar en las fresas y las chokeberries. | ||||
| GC47955 | Phloroglucinol | 108-73-6 | >99.00% | |
A phenol with diverse biological activities | ||||
| GC47977 | Propiconazole | 60207-90-1 | >96.00% | |
Propiconazole es un triazol N-sustituido activo por vía oral con actividad antifúngica. | ||||
| GC47978 | Propiconazole-d3 (nitrate) | 2699607-26-4 | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC47979 | Propiconazole-d7 | 1246818-14-3 | >99.00% | |
An internal standard for the quantification of propiconazole | ||||
| GC47980 | Propionyl-L-carnitine-d3 (chloride) | 1334532-19-2 | >99.00% | |
An internal standard for the quantification of propionyl-L-carnitine | ||||
| GC48019 | Quercetin (hydrate) | 849061-97-8 | >96.00% | |
Quercetin (hydrate) is the dihydrate form of the flavonoid quercetin, which possesses various biological activities. | ||||
| GC48020 | Quercetin-d3 (hydrate) | - | >99.00% | |
A neuropeptide with diverse biological activities | ||||
| GC48029 | RC363 | 2584411-86-7 | >98.00% | |
An inhibitor of ferroptosis | ||||
| GC48030 | RC574 | 2584411-87-8 | >98.00% | |
An inhibitor of ferroptosis | ||||
| GC48120 | T-2 Toxin-13C24 | 21259-20-1 | >98.00% | |
A neuropeptide with diverse biological activities | ||||
| GC48162 | Theobromine-d6 | 117490-40-1 | >99.00% | |
An internal standard for the quantification of theobromine | ||||
| GC48194 | trans-Resveratrol-d4 | 1089051-56-8 | >99.00% | |
An internal standard for the quantification of trans-resveratrol | ||||
| GC48247 | Verrucarin A | 3148-09-2 | ≥70.00% | |
La verrucarina A (muconomicina A), una micotoxina macrocÍclica de tipo D derivada del hongo patÓgeno Myrothecium verrucaria, es un inhibidor de la sÍntesis de proteÍnas. Verrucarin A inhibe el crecimiento de las lÍneas celulares de leucemia y activa las caspasas y la apoptosis y la seÑalizaciÓn inflamatoria en los macrÓfagos. Verrucarin A aumentÓ efectivamente la fosforilaciÓn de p38 MAPK y disminuyÓ la fosforilaciÓn de ERK/Akt. Verrucarin A provocÓ la desregulaciÓn del ciclo celular a través de la inducciÓn de p21 y p53. | ||||