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Reactive Oxygen Species

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Reactive oxygen species (ROS), such as superoxide anion (O2-), hydrogen peroxide (H2O2), and hydroxyl radical (HO•), consist of radical and non-radical oxygen species formed by the partial reduction of oxygen. Cellular ROS are generated endogenously during mitochondrial oxidative metabolism as well as in cellular response to xenobiotics, cytokines, and bacterial invasion.

ROS also activates MAPK pathways by the direct inhibition of MAPK phosphatases. Through PTEN, the PI3K pathway is subject to reversible redox regulation by ROS generated by growth factor stimulation. The activation of autophagy may be a cellular defense mechanism in response to ROS.

Products Related to Reactive Oxygen Species(505)

  • GC72755 structure
    GC72755Tempol-d17,15N
    CAS: 90429-66-6

    Tempol-d17,15N es el deuterio llamado Tempol.

  • GC72791 structure
    GC72791Delmitide acetate
    CAS: 501019-16-5
    Purity: >98.00%

    Delmitide acetate es un décapéptido oral activo del isómero d con potente actividad antiinflam.

  • GC72858 structure
    GC72858Avenanthramide A
    CAS: 108605-70-5
    Purity: >99.00%

    Avenanthramide A es una ptoalexina, que se puede encontrar en Avena (Avena sativa L.).

  • GC72888 structure
    GC72888CPS-11
    CAS: 145945-21-7
    Purity: >99.00%

    CPS-11 (N-(droxymetl) talidomide) un análogo de talidomi, es un potente agente anticanceroso.

  • GC72995 structure
    GC72995MnTE-2-PyP chloride
    CAS: 219818-60-7
    Purity: >95.00%

    MnTE-2-PyP chloride es un destructor de ROS y potente radioprotector.

  • GC73031 structure
    GC73031Salpyran dihydrochloride
    Purity: >99.00%

    Salpyran dihydrochloride es un quelselectivo Cu(II) con potencial terapéutico.

  • GC73188 structure
    GC73188SFI003
    CAS: 2361332-90-1
    Purity: >99.00%

    SFI003 es un inhibidor de SRSF3 que conduce la apoptosis de las células del CRC a través del eje SRSF3/DHCR24/ROS y exhibe potentes efectos antitumorales tanto in vitro como in vivo.

  • GC73212 structure
    GC73212TH-6
    CAS: 3031349-25-1
    Purity: >95.00%

    TH-6 es un potente inhibidor de HDAC con IC50s de 0,115, 0,135, 0,242, 0,138, 2,120 µM para HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectivamente.

  • GC73225 structure
    GC73225ROS-generating agent 1
    CAS: 2369030-41-9
    Purity: >99.00%

    ROS-generating agent 1 (compuesto 2c) modifica covalentemente el residuo Sec-498 de TrxR para generar ROS.

  • GC73543 structure
    GC73543FC-116
    CAS: 2417298-29-2
    Purity: >98.00%

    FC-116 es un inhibidor de la tubulina que inhieficazmente el crecimiento tumoral en ratones.

  • GC74090 structure
    GC74090Dimethyl fumarate-d2
    CAS: 23057-98-9
    Purity: >99.00%

    Dimethyl fumarate-d2 es el deuterio etiquetado Dimetl fumarato.

  • GC74256 structure
    GC74256Condurango glycoside A
    CAS: 11051-90-4
    Purity: >95.00%

    Condurango glycoside A es un activador de p53.

  • GC74270 structure
    GC74270Penduletin
    CAS: 569-80-2
    Purity: >99.00%

    Penduletin es una flavona, que puede ser aislada de Brickelia pendula y Vitex negundo.

  • GC74668 structure
    GC746683-Methoxy-9H-Carbazole
    CAS: 18992-85-3
    Purity: >99.00%

    3-Methoxy-9H-Carbazole induce la actividad de la caspas-3 y la generación celular de especies de oxígeno eactivo.

  • GC81540 structure
    GC81540Brevicidine TFA
    Purity: >97.50%

    Brevicidine TFA is an antimicrobial peptide with selective bactericidal activity against Gram-negative pathogens.

  • GC81541 structure
    GC81541BMAP-27 acetate
    Purity: >98.00%

    BMAP-27 acetate is a cationic amphipathic α-helical antimicrobial peptide with anticancer activity.

  • GC81542 structure
    GC815427-O-Galloyl-D-sedoheptulose
    CAS: 233690-85-2
    Purity: >98%

    7-O-Galloyl-D-sedoheptulose is an orally effective polyphenolic compound.

  • GC81543 structure
    GC81543GPX4-IN-19
    CAS: 3102894-57-2
    Purity: >99.00%

    GPX4-IN-19 is an effective GPX4 inhibitor ( IC 50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4.

  • GC81544 structure
    GC81544Copper ionophore I
    CAS: 101264-90-8
    Purity: >98.00%

    Copper ionophore I is an efficient copper ion carrier.

  • GC81545 structure
    GC81545Ferroptosis inducer-12
    Purity: >96.00%

    Ferroptosis inducer-12 is a potent and selective ferroptosis inducer.

  • GC81546 structure
    GC81546iMQT_020
    CAS: 2463893-46-9
    Purity: >99.00%

    iMQT_020 is a selective allosteric SLC1A5_var inhibitor.

  • GC81547 structure
    GC81547Geranyl isovalerate
    CAS: 109-20-6
    Purity: >96.50%

    Geranyl isovalerate is a chemical component that can be extracted from Argyreia Nervosa.

  • GC81548 structure
    GC81548CIGB-552 TFA
    Purity: >98.00%

    CIGB-552 TFA is a cell-penetrating peptide with anti-tumor properties with the IC 50 of 23 μM in H460 cells.

  • GC81553 structure
    GC81553YRDC-IN-1
    CAS: 3120494-74-5
    Purity: >93.50%

    YRDC-IN-1 is a blood-brain barrier-permeable YRDC inhibitor.