Na+/K+ ATPase

Na⁺/K⁺ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na⁺/K⁺ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na⁺/K⁺-ATPase (NKA, or Na⁺ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Products Related to Na+/K+ ATPase(30)

GC79494 ATPase-IN-7
CAS: 816450-73-4
Purity: >99.50%
ATPase-IN-7 (Example 1) is a H + /K + -ATPase inhibitor.
GC81320 Papaveroline
CAS: 574-77-6
Purity: >98%
Papaveroline is a Fyn tyrosine kinase inhibitor, Na +,K + -ATPase inhibitor with an IC 50 of 0.20 mM, Mg 2+ -ATPase inhibitor, K + -activated pNPPase inhibitor with an IC 50 of 1.51 mM, and apoptosis inducer [1] [2] [3] . Papaveroline binds to the active site of Fyn tyrosine kinase and forms stable interactions with pocket amino acid residues [1] . Papaveroline induces cell apoptosis, produces pycnotic and fragmented cell nuclei, and does not reduce intracellular ATP levels [3] . Papaveroline is a dopamine-derived neurotoxin candidate associated with the pathogenesis of Parkinson's disease [3] . Papaveroline can be used in the research of Alzheimer's disease and Parkinson's disease [3] .
GN10029 Phloridzin
CAS: 60-81-1
Purity: >98.00%
GN10144 Oleandrin
CAS: 465-16-7
Purity: >99.00%
GN10156 Ginsenoside Rb1
CAS: 41753-43-9
Purity: >98.00%
Ginsenoside Rb1 is a natural active ingredient extracted from ginseng that can modulate the activity of multiple signaling pathways.
GN10365 Bufalin
CAS: 465-21-4
Purity: >99.50%
Bufalin es un inhibidor de Na + /K + -ATPase (α1: K d = 42.5nM; α2: K d = 45nM; α3: K d = 40nM)

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC79494	ATPase-IN-7	816450-73-4	>99.50%
GC79494	ATPase-IN-7 (Example 1) is a H + /K + -ATPase inhibitor.
GC81320	Papaveroline	574-77-6	>98%
GC81320	Papaveroline is a Fyn tyrosine kinase inhibitor, Na +,K + -ATPase inhibitor with an IC 50 of 0.20 mM, Mg 2+ -ATPase inhibitor, K + -activated pNPPase inhibitor with an IC 50 of 1.51 mM, and apoptosis inducer [1] [2] [3] . Papaveroline binds to the active site of Fyn tyrosine kinase and forms stable interactions with pocket amino acid residues [1] . Papaveroline induces cell apoptosis, produces pycnotic and fragmented cell nuclei, and does not reduce intracellular ATP levels [3] . Papaveroline is a dopamine-derived neurotoxin candidate associated with the pathogenesis of Parkinson's disease [3] . Papaveroline can be used in the research of Alzheimer's disease and Parkinson's disease [3] .
GN10029	Phloridzin	60-81-1	>98.00%
GN10144	Oleandrin	465-16-7	>99.00%
GN10156	Ginsenoside Rb1	41753-43-9	>98.00%
GN10156	Ginsenoside Rb1 is a natural active ingredient extracted from ginseng that can modulate the activity of multiple signaling pathways.
GN10365	Bufalin	465-21-4	>99.50%
GN10365	Bufalin es un inhibidor de Na + /K + -ATPase (α1: K d = 42.5nM; α2: K d = 45nM; α3: K d = 40nM)