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FAAH

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Fatty acid amide hydrolase (FAAH), belonging to an amidase-signature (AS) protein family, is a membrane-bound protein predominantly in microsomal and mitochondrial fractions that catalyzes the hydrolysis of several bioactive lipids, including anandamide, 2-arachidonoylglycerol (2-AG) and oleamide. The mammalian FAAHs are 63 kDa (579 amino acids in length) proteins characterized by containing several domains defined by homology and function, including, a highly conserved seine-and-glycine-rich AS domain, a predicted transmembrane domain and a proline rich domain. Results of mutation studies suggest, unlike other members of AS protein family, the catalytic activity of FAAH is not associated with the Ser-His-Asp triad but possibly with Ser217 and Lys142.

Products Related to FAAH(36)

  • GC35068 structure
    GC350681-Monomyristin
    CAS: 589-68-4
    Purity: >98.00%

    La 1-monomiristina, extraÍda de Serenoa repens, inhibe la hidrÓlisis del 2-oleoilglicerol (IC50=32 μM) y la actividad de la amida hidrolasa de Ácidos grasos (FAAH) (IC50=18 μM).

  • GC36023 structure
    GC36023FAAH inhibitor 1
    CAS: 326866-17-5
    Purity: >98%

    El inhibidor 1 de FAAH (anÁlogo 3 de benzotiazol) es un potente inhibidor de la amida hidrolasa de Ácidos grasos (FAAH) con una IC50 de 18±8 nM.

  • GC36671 structure
    GC36671N-Benzyllinolenamide
    CAS: 883715-18-2
    Purity: >98%

    La N-Benzillinolenamida es una macamida natural aislada de Lepidium meyenii, actúa como inhibidor de la amida hidrolasa de ácidos grasos (FAAH) con una IC50 de 41,8 μM.

  • GC36703 structure
    GC36703N-Benzyloleamide
    CAS: 883715-21-7
    Purity: >98.00%

    La N-benciloleamida es una maccamida aislada de Lepidium meyenii (Maca).

  • GC36879 structure
    GC36879PF-04457845
    CAS: 1020315-31-4
    Purity: >99.00%

    PF-04457845 es un inhibidor de FAAH altamente eficaz y selectivo con valores de IC50 de 7,2 ± 0,63 nM y 7,4 ± 0,62 nM para hFAAH y rFAAH, respectivamente.

  • GC63641 structure
    GC63641SSR411298
    CAS: 666860-59-9
    Purity: >98%

    SSR411298 es un inhibidor de la amida hidrolasa de Ácidos grasos (FAAH) selectivo y reversible activo por vÍa oral.

  • GC68837 structure
    GC68837CB2R/FAAH modulator-2
    CAS: 2876918-68-0
    Purity: >98%

    CB2R/FAAH modulator-2 (compuesto 26) is a dual-targeted regulator that can act as a CB2R agonist and FAAH inhibitor. The Ki values for CB2R and CB1R are 10.8 and 152.9 nM, respectively, while the IC50 value for FAAH is 6.2 μM. CB2R/FAAH modulator-2 can be used in research related to harmful inflammatory cascades occurring in cancer, neurodegenerative diseases, and COVID-19 infections.

  • GC68838 structure
    GC68838CB2R/FAAH modulator-3
    CAS: 2876918-67-9
    Purity: >99.00%

    CB2R/FAAH modulator-3 (compuesto 27) is a dual-targeted regulator that can act as a CB2R agonist and FAAH inhibitor. The Ki values of CB2R/FAAH modulator-3 on CB2R and CB1R are 20.1 and 67.6 nM, respectively, while its IC50 value on FAAH is 3.4 μM. CB2R/FAAH modulator-3 can be used for research related to harmful inflammatory cascades occurring in cancer, neurodegenerative diseases, and COVID-19 infections.

  • GC70775 structure
    GC70775FP-Biotin
    CAS: 259270-28-5
    Purity: >99.00%

    FP-Biotin es un potente tóxico organofosforado, muy adecuado para la búsqueda de nuevos marcadores biológicos de exposición a tóxicos organofosforados.

  • GC70904 structure
    GC70904Dual FAAH/sEH-IN-1
    CAS: 2756099-59-7

    Dual FAAH/sEH-IN-1 (compuesto 3) es un inhibidual de alta afinseh (epóxido hidrolasa soluble) y FAAH (ácido graso amida hidrolasa), con valores de IC50 de 9,6 y 7 nM, respectivamente.

  • GC74079 structure
    GC74079Sob-AM2
    CAS: 2128258-47-7

    Sob-AM2 es un potente sustrque apunta a la amida drolasa de ácido graso (FAAH) expresada en el cerebro (Km=1.3 μM).

  • GN10618 structure
    GN10618Biochanin A
    CAS: 491-80-5
    Purity: >99.50%