Sterol Biosynthesis

3-Formylsalicylic acid is a non-competitive inhibitor of estrone sulfatase (IC50 = 150 nM; Ki = 120 nM), the enzyme that converts estrone sulfate to estrone.

Brassinazole is a selective triazole-type brassinosteroid (BR) biosynthesis inhibitor. Brassinazole is used for regulating plant growth and development.

ACTH (6-24) is a peptide fragment of adrenocorticotropic hormone, a peptide hormone found in the brain that is involved in the biological stress response.

Fluvastatin-d6 is intended for use as an internal standard for the quantification of fluvastatin by GC- or LC-MS.

5α-hidroxi-6-ceto El colesterol es el principal metabolito de β-epÓxido (5α,6β-epoxicolesterol) durante la exposiciÓn directa de células epiteliales bronquiales humanas cultivadas intactas (16-HBE) al ozono.

Acyl-Coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.

Acyl-coenzyme A: cholesterol acyltransferase-1 and -2 (ACAT-1 and ACAT-2) catalyze the formation of cholesterol esters from cholesterol and long chain fatty acyl-coenzyme A, and may play a role in the development of atherosclerosis.

Dutasteride-13C6 is intended for use as an internal standard for the quantification of dutasteride by GC- or LC-MS.

AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.

AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol.

Acyl-CoA:cholesterol acyltransferase (ACAT) catalyses the esterification of excess cellular cholesterol with fatty acids and is important for intestinal cholesterol absorption, hepatic lipoprotein secretion, and cholesterol accumulation in vascular tissues.

An internal standard for the quantification of tolnaftate

An internal standard for the quantification of naftifine

A neuropeptide with diverse biological activities

El acetato de abiraterona-d4 (CB7630-d4) es el acetato de abiraterona marcado con deuterio. El acetato de abiraterona (CB7630) es un inhibidor oral, potente, selectivo e irreversible de CYP17A1 con actividad antiandrÓgena. El acetato de abiraterona es una forma de profÁrmaco de abiraterona (CB7598).

An HMG-CoA reductase inhibitor

A neuropeptide with diverse biological activities

Finasteride-d9 es Finasteride etiquetado con deuterio. Finasteride (MK-906) es un inhibidor potente y competitivo de la 5α-reductasa, con una IC50 de 4,2 nM para la 5α-reductasa de tipo II. La finasterida tiene una afinidad aproximadamente 100 veces mayor por la enzima 5α-reductasa de tipo II que por la enzima de tipo I. Finasteride se puede utilizar para la investigaciÓn de la hiperplasia prostÁtica benigna (HPB) y la alopecia androgénica.

An internal standard for the quantification of itraconazole

Letrozol-d4 (CGS 20267-d4) es el deuterio etiquetado como Letrozol. Letrozol (CGS 20267) es un inhibidor no esteroideo de la aromatasa potente, selectivo, reversible y activo por vía oral, con una IC50 de 11,5 nM. El letrozol inhibe selectivamente la biosíntesis de estrógenos y puede utilizarse para la investigación del cáncer de mama.

An internal standard for the quantification of terbinafine

A neuropeptide with diverse biological activities

An internal standard for the quantification of butenafine

Ganodermanontriol, un esterol aislado de Ganoderma lucidum, induce actividad antiinflamatoria en células hepÁticas daÑadas por hidroperÓxido de terc-butilo (t-BHP) a través de la expresiÓn de HO-1. Ganodermanontriol exhibe actividad hepatoprotectora.