Obesity, Appetite Control & Diabetes

Ghrelin is an endogenous gastrointestinal hormone and neuropeptide that binds to the growth hormone (GH) secretagogue receptor (GHS-R).

GLP-1 (7-36) amide is a peptide hormone released from intestinal L-cells upon nutrient consumption.

Glucagon-like peptide-1 (GLP-1) (7-37) is an endogenous incretin hormone and truncated form of GLP-1 (1-37) that is produced via cleavage of preproglucagon in the pancreas and intestine.

Glucagon-like peptide-2 (GLP-2) is an endogenous peptide hormone formed in L cells of the small and large intestine by cleavage of proglucagon in response to nutrient ingestion.

An inactive control for glucagon receptor antagonist I

Glucocerebrosides are formed by the tethering of glucose to a ceramide by glucosylceramide synthase.

Glyburide is a sulfonylurea and an inhibitor of sulfonylurea receptor 1 (SUR1) linked to ATP-sensitive potassium channel Kir6.2 (IC50 = 4.3 nM).

Glycolithocholic Acid, un conjugado de ácido biliares secundarios y glicina, es un producto metabólico endógeno dentro del cuerpo

Glycolithocholic acid is a glycine conjugate of lithocholic acid, a bile acid.

GW9578 es un agonista de PPARα selectivo de subtipo (CE50 de 5 y 50 nM para PPAR-α murino y humano) con una potente actividad reductora de lÍpidos.

Fasudil (HA-1077; AT877) dihidrocloruro es un inhibidor rhoa/roca inespecÍfico y también tiene un efecto inhibitorio en las proteÍnas quinasas, con un KI de 0.33 ⋼ m para el rock111&&&&&&77TRESTO. offlineefficient_models_2022q2.md;M, 1.650 μM for ROCK2 and PKA, PKC, PKG, respectively.en_es_2021q4.mdHA-1077 (hydrochloride) is also a potent Ca2+ channel antagonist and vasodilator.en_es_2021q4.md

Ghrelin is an endogenous ligand for the growth hormone secretagogue receptor that stimulates food intake and transduces signals to hypothalamic regulatory nuclei that control energy homeostasis.

Lactisole es un antagonista canónico del receptor del sabor dulce, dirigido selectivamente a la subunidad T1R3

Lithocholic acid 3-sulfate is a metabolite of the secondary bile acid lithocholic acid.

MHY908 es un potente agonista dual de PPARα y PPARγ.

ML-262 is an inhibitor of hepatic lipid droplet formation (IC50 = 6.4 nM in murine AML-12 cells), which is associated with non-alcoholic fatty liver disease.

MLS-0322825 Cmpd 23 es un inhibidor selectivo de la proteÍna tirosina fosfatasa de bajo peso molecular (LMPTP), con una IC50 de 0,8 μM LMPTP-A.

Agmatine is a natural polyamine formed by the enzymatic decarboxylation of arginine.

ND-336 es un inhibidor selectivo de la metaloproteinasa de matriz (MMP)-2, MMP-9 y MMP-14, con Kis de 85, 150 y 120 nM, respectivamente.

Neuromedin S is a neuropeptide expressed in brain.

N-Oleoyl Leucine is a fatty acid–amino acid conjugate (FAAA) that belongs to the family of N-acyl amino acids.

O-7460 es un inhibidor de DAGLα potente y selectivo, con una IC50 de 0,69 μM.

Obestatin is a 23-amino acid peptide hormone that is formed by cleavage of the ghrelin and obestatin prepropeptide.

Orlistat degradation product is a degradation product of the digestive lipase inhibitor orlistat.