GLPBio

E3 Ligase Ligand-Linker Conjugate

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E3 Ligase Ligand-Linker Conjugate, which is one part of Proteolysis Targeting Chimeric Molecules (PROTACs), incorporates a ligand for the E3 ubiquitin ligase and a linker. After linked to the ligand for target protein (such as JQ1 for BRD4 protein, Molibresib for BET protein), those conjugates can be used for constituting PROTACs that targetprotein for ubiquitination and degradation. Currently, several PROTACs have been found to show good biological activity by specifically targeting BET, estrogen receptor (ER), androgen receptor, etc.MedChemExpress (MCE) offers a wide range of high quality E3 Ligase Ligand-Linker Conjugates including von Hippel-Lindau (VHL) ligands, MDM2 ligands, Cereblon (CRBN) ligands and cIAP1 ligands conjugating with different linkers (PEGs, Alkyl-Chain, Alkyl/ether, etc.). It’s convenient and time-saving for designing and synthesizinga wide variety of novel PROTACs (ARV-825, dBET1,MT-802, etc.), which can expand the application of PROTACs in the treatment of cancer, autoimmunity, inflammation and other diseases.

Products Related to E3 Ligase Ligand-Linker Conjugate(201)

  • GC70024 structure
    GC70024Thalidomide-O-C6-azide
    CAS: 2411389-65-4
    Purity: >99.00%

    Thalidomide-O-C6-azide es un conjugado de ligando-linker de E3 Ligase, que contiene un ligando cereblon basado en la talidomida y 1 linker.

  • GC70816 structure
    GC70816Pomalidomide-C5-azide
    CAS: 2434629-02-2
    Purity: >97.00%

    Pomalidomide-C5-azide es un ligand linker conjude de ubiquitina ligasa cereblon (CRBN).

  • GC73001 structure
    GC73001Thalidomide-4-O-C10-NH2 hydrochloride
    Purity: >95.00%

    Thalidomide-4-O-C10-NH2 hydrochloride es el ligde cereblón a base de talidomiutilizado en el reclutamiento de la proteína CRBN.

  • GC73071 structure
    GC73071Thalidomide-5-PEG3-NH2 hydrochloride
    CAS: 2761385-81-1
    Purity: >97.00%

    Thalidomide-5-PEG3-NH2 hydrochloride es una ligasa E3 sintetizligand-linker conjugque incorpora el ligligcereblon basado en talidomide y un ligligutilizado en la tecnología PROTAC.

  • GC73095 structure
    GC73095(S,S,R)-AHPC-C6-NH2 hydrochloride
    Purity: >97.00%

    (S,S,R)-AHPC-C6-NH2 hydrochloride es la forma de sal droclorde S,S,R-AHPC-C6-NH2.

  • GC73164 structure
    GC73164Pomalidomide-C6-O-C5-O-C4-COOH
    CAS: 2375774-54-0
    Purity: >98.00%

    Pomalidomide-C6-O-C5-O-C4-COOH es un ligligligand-linker conjue3 ligase que comprende un ligligcerey linker basado en Pomalidomide.

  • GC73431 structure
    GC73431Pomalidomide-C11-NH2 hydrochloride
    CAS: 2722611-55-2

    Pomalidomide-C11-NH2 hydrochloride es el cereblon basado en pomalidomi(CRBN) ligand utilizado en el reclutamiento de la proteína CRBN.

  • GC73558 structure
    GC73558Pomalidomide-5-C9-NH2 hydrochloride
    CAS: 2925306-22-3
    Purity: >98.00%

    Pomalidomide-5-C9-NH2 hydrochloride es el cereblon basado en pomalidomi(CRBN) ligand utilizado en el reclutamiento de la proteína CRBN.

  • GC73559 structure
    GC73559Pomalidomide-5-C11-NH2 hydrochloride
    Purity: >98.00%

    Pomalidomide-5-C11-NH2 hydrochloride es el cereblon basado en pomalidomi(CRBN) ligand utilizado en el reclutamiento de la proteína CRBN.

  • GC73560 structure
    GC73560Pomalidomide-5-C12-NH2 hydrochloride
    Purity: >98.00%

    Pomalidomide-5-C12-NH2 hydrochloride es el cereblon basado en pomalidomi(CRBN) ligand utilizado en el reclutamiento de la proteína CRBN.

  • GC73862 structure
    GC73862Lenalidomide-C5-acid
    CAS: 2338824-30-7
    Purity: >96.00%

    Lenalidomide-C5-acid es la ligasa E3 ligand-linker conjugbasada en lenalidomiusada en el reclutamiento de la proteína CRBN.

  • GC74706 structure
    GC74706Thalidomide-5-O-CH2-COOH
    CAS: 2467425-53-0
    Purity: >95.00%

    Thalidomide-5-O-CH2-COOH es una ligasa E3 Ligand-Linker conjugque consiste en talidomide y NH-PEG3-NH-Boc.

  • GC80883 structure
    GC80883Thalidomide-O-amide-C5-NH2 hydrochloride
    CAS: 2716130-28-6
    Purity: >95.50%

    Thalidomide-O-amide-C5-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology [1] [2] .

  • GC80897 structure
    GC80897Desamino lenalidomide-C2-COOH
    CAS: 2703770-71-0
    Purity: >98.00%

    Desamino lenalidomide-C2-COOH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80898 structure
    GC80898Thalidomide-O-C2-alkyne
    CAS: 2357110-34-8
    Purity: >99.50%

    Thalidomide-O-C2-alkyne is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80899 structure
    GC80899Thalidomide-azetidine-C-OH
    CAS: 2241314-93-0
    Purity: >98.50%

    Thalidomide-azetidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80900 structure
    GC80900(S)-Glutarimide-amide-Py-piperidine-CHO
    CAS: 2649400-06-4
    Purity: >99.00%

    (S)-Glutarimide-amide-Py-piperidine-CHO is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80901 structure
    GC80901Desamino lenalidomide-piperidine-CO
    CAS: 2413037-88-2
    Purity: >98.00%

    Desamino lenalidomide-piperidine-CO is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80902 structure
    GC80902Desamino lenalidomide-Pip hydrochloride
    CAS: 2291360-60-4
    Purity: >99.00%

    Desamino lenalidomide-Pip hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80903 structure
    GC80903Pomalidomide-piperazine hydrochloride
    CAS: 2230956-83-7
    Purity: >97.00%

    Pomalidomide-piperazine hydrochloride is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80904 structure
    GC80904Thalidomide-piperidin-4-ylmethanol
    CAS: 2229717-49-9
    Purity: >99.00%

    Thalidomide-piperidin-4-ylmethanol is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80905 structure
    GC80905Thalidomide-6-F-5-pip-CHO
    CAS: 2505502-00-9
    Purity: >95.00%

    Thalidomide-6-F-5-pip-CHO is a synthetic E3 ligase ligand-conjugate that can be used for the synthesis of PROTACs, such as DN1679 [1] .

  • GC80906 structure
    GC80906Thalidomide 5-fluoride 6-piperidine-C-OH
    CAS: 2505501-99-3
    Purity: >98.00%

    Thalidomide 5-fluoride 6-piperidine-C-OH is an E3 ligase ligand-linker conjugate containing a CRBN-based ligand and linker, which can be used to synthesize PROTAC.

  • GC80907 structure
    GC80907Desamino lenalidomide-acetylene-C2-NH2 TFA
    CAS: 3065251-37-5
    Purity: >98.00%

    Desamino lenalidomide-acetylene-C2-NH2 TFA is an E3 ligand-linker conjugate that incorporates a ligand based on CRBN and a linker, and can be used for the synthesis of PROTAC.