Drug Metabolite

3-hydroxy Desloratidine is a major metabolite of desloratadine , a tricyclic antagonist of the histamine H1 receptor.

3-O-methyl-L-DOPA is a metabolite of L-DOPA, produced by the activity of catechol O-methyltransferase.

4-Desmetoxi Omeprazol es el metabolito activo de Omeprazol.

4-hydroperoxy Cyclophosphamide, el metabolito activo de la ciclofosfamida, puede entrecruzar el ADN e inducir la apoptosis de células T de manera independiente de la activación de los receptores de caspasa. Además, activa la vía mitocondrial de muerte celular mediante la producción de especies reactivas de oxígeno (ROS).

4-hydroxy (S)-Duloxetine β-D-glucuronide is an inactive metabolite of the serotonin and norepinephrine reuptake inhibitor (S)-duloxetine.

4-hydroxy Atorvastatin is a metabolite of atorvastatin, an HMG-CoA reductase inhibitor present in formulations that have been used to treat hypercholesterolemia and certain dyslipidemias.

El 4-hidroxi diclofenaco es un metabolito oralmente activo del diclofenaco por el citocromo P450 2C9 (CYP2C9).

4-hydroxy Nebivolol is a major metabolite of nebivolol.

4-hydroxy Valsartan is a major metabolite of the angiotensin II type 1 (AT1) receptor antagonist valsartan.

5-hydroxy Diclofenac is a metabolite of the NSAID diclofenac formed by the cytochrome P450 (CYP) isoform CYP3A4.

5-hydroxy Saxagliptin is a major active metabolite of saxagliptin.

5-hydroxy Thiabendazole (5-OH TBZ) is a major metabolite of the anthelmintic thiabendazole.

5-hydroxy-6-methoxy (S)-Duloxetine is a metabolite of (S)-duloxetine.

5-hydroxymethyl Tolterodine is an active metabolite of the muscarinic acetylcholine receptor antagonists tolterodine and fesoterodine.

6-hydroxy Chlorzoxazone is the primary metabolite of Chlorzoxazone in vivo. 6-hydroxy Chlorzoxazone is mainly formed through the hepatic cytochrome P450 enzyme system and is commonly used as a probe in biochemical research to quantitatively evaluate CYP2E1 activity.

6-O-desmethyl Donepezil is an active metabolite of the acetylcholinesterase inhibitor donepezil.

6α-hidroxi Paclitaxel es un metabolito primario de Paclitaxel. 6α-hidroxi Paclitaxel conserva un efecto dependiente del tiempo sobre los polipéptidos transportadores de aniones orgÁnicos 1B1/SLCO1B1 (OATP1B1) con una potencia de inhibiciÓn similar a Paclitaxel, mientras que ya no mostrÓ inhibiciÓn dependiente del tiempo de OATP1B3. 6α-hidroxi Paclitaxel se puede utilizar para la investigaciÓn del cÁncer.

7-hydroxy Coumarin Glucuronide (sodium salt) is a phase II metabolite of 7-hydroxycoumarin formed by glucuronidation.

7-hydroxy Coumarin sulfate is a phase II metabolite of coumarin that can be used as an internal standard for the analysis of 7-hydroxy coumarin metabolism using GC- or LC-MS.

7-hydroxy Methotrexate (7-hydroxy MTX) is a phase I metabolite of MTX, which is converted by hepatic aldehyde oxidases.

8-hydroxy Efavirenz is a major oxidative metabolite of the non-nucleoside reverse transcriptase inhibitor efavirenz.

(9E)-Erythromycin A oxime is a metabolite of the semisynthetic antibiotic roxithromycin .

Abacavir carboxylate is an inactive metabolite of the HIV-1 reverse transcriptase inhibitor abacavir.

Acecainide is an active metabolite of the class III antiarrhythmic procainamide.