GLPBio

HCV Protease

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Hepatitis C virus (HCV) protease is an enzyme, either viral or cellular, that catalyzes the hydrolysis of the long polyprotein precursor (approximately 3000 amino acids) encoded by HCV genome into at least ten individual proteins, including four structural proteins (C, E1, E2 and p7) and six nonstructural (NS) proteins (NS2, NS3, NS4A, NS4B, NS5A and NS5B). The commonly studied HCV proteases are two virally encode proteases involved in the viral replication of HCV, including HCV NS2/3 protease, a highly hydrophobic protease responsible for the cleavage of NS2 and NS3, and HCV NS3-4A serine protease, a covalent heterodimer responsible for cleavage at four sites of the HCV polyprotein.

Products Related to HCV Protease(37)

  • GC25117 structure
    GC25117Azvudine
    CAS: 1011529-10-4
    Purity: >98%

    Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).

  • GC32305 structure
    GC32305ACH-806 (GS9132)
    CAS: 870142-71-5
    Purity: >98%

    ACH-806 (GS9132) es un antagonista de NS4A que puede inhibir la replicaciÓn del virus de la hepatitis C (VHC) con una CE50 de 14 nM.

  • GC37921 structure
    GC37921Voxilaprevir
    CAS: 1535212-07-7
    Purity: >99.50%

    Voxilaprevir (GS-9857) es un inhibidor reversible no covalente del inhibidor de la proteasa (PI) NS3/4A del VHC con actividad antiviral pangenotÍpica.

  • GC60947 structure
    GC60947Isoeuphorbetin
    CAS: 50886-61-8
    Purity: >98%

    La isoeuforbetina, una cumarina dimérica aislada de Viola philippica, es un potente inhibidor de la proteasa del VHC con una IC50 de 3,63 μg/mL.

  • GC64016 structure
    GC64016Samatasvir
    CAS: 1312547-19-5
    Purity: >99.00%

    Samatasvir (IDX71) es un potente inhibidor NS5A activo por vÍa oral de la replicaciÓn del VHC.

  • GC64038 structure
    GC64038Simeprevir-13C,d3
    CAS: 923604-59-5
    Purity: >98%

    Simeprevir-13C,d3 (TMC435-13C,d3) es el Simeprevir marcado con 13C y deuterio.

  • GC64065 structure
    GC64065Coblopasvir
    CAS: 1312608-46-0
    Purity: >98%

    Coblopasvir (KW-136) es un inhibidor pangenotÍpico de la proteÍna 5A no estructural (NS5A).

  • GC64066 structure
    GC64066Coblopasvir dihydrochloride
    CAS: 1966138-53-3
    Purity: >98%

    El diclorhidrato de coblopasvir (KW-136) es un inhibidor pangenotÍpico no estructural de la proteÍna 5A (NS5A).

  • GC65345 structure
    GC65345BI 653048
    CAS: 1198784-72-3
    Purity: >98%

    BI 653048 es un agonista de glucocorticoides (GC) no esteroideos selectivo y activo por vÍa oral con un valor IC50 de 55 nM.

  • GC68453 structure
    GC68453ITMN 4077
    CAS: 790305-05-4
    Purity: >99.00%
  • GC71538 structure
    GC71538IDX184
    CAS: 1036915-08-8
    Purity: >99.00%

    IDX184 es un potente inhibibiodisponible de la replicación del VHC.

  • GC71540 structure
    GC71540JTK-109
    CAS: 480462-62-2

    JTK-109 es un potente inhibidor de la ARN polimerasa dependiente del virus de la hepatitis C NS5B.

  • GP10026 structure
    GP10026Hepatitis C virus
    Purity: >98%

    Hepatitis C virus, (C48H88N10O13S), a peptide with the sequence H2N-Leu-Leu-Ala-Leu-Leu-Ser-Cys-Leu-Thr-Val-OH, MW= 1045.34.