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HIV Protease

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Human immunodeficiency virus (HIV) protease, belonging to the aspartic proteinase family, is an enzyme encoded by the pol open reading frame (ORF) of HIV genome that catalyze the posttranslational processing of the HIV polyproteins to yield structural proteins of the viral core and enzymes. The chemical structure of a HIV protease molecule is a symmetrical homodimer in which the interface is formed primarily by a four-stranded antiparallel β-sheet. A conserved D25-T26-G27 triad has been identified in each HIV protease monomer, which is positioned in a loop forming part of the catalytic site. HIV protease has been found to cleave peptide bonds in the p55 gag and p160 gag-pol polyproteins as well as in various cellular proteins in vitro, including calmodulin, pro-interleukin 1β and NF-KB.

Products Related to HIV Protease(35)

  • GC36872 structure
    GC36872Pepstatin Trifluoroacetate
    Purity: >99.00%

    El trifluoroacetato de pepstatina (trifluoroacetato de pepstatina A) es un inhibidor de la proteasa aspÁrtica especÍfico producido por actinomicetos, con IC50 de 4,5 nM, 6,2 nM, 150 nM, 290 nM, 520 nM y 260 nM para hemoglobina-pepsina, hemoglobina-proctasa, caseÍna-pepsina, caseÍna-proctasa, caseÍna-proteasa Ácida y hemoglobina-proteasa Ácida, respectivamente.

  • GC39068 structure
    GC39068Rosamultin
    CAS: 88515-58-6
    Purity: >98.00%

    Rosamultin es un triterpenoide de tipo 19 α-hidroxiursano aislado de Potentilla anserinaL.

  • GC43358 structure
    GC43358Cytochalasin A
    CAS: 14110-64-6
    Purity: >98.00%

    La citocalasina A es una toxina fÚngica permeable a las células que es un derivado oxidado de la citocalasina B.

  • GC64331 structure
    GC64331Ritonavir-13C,d3
    CAS: 155213-67-5
    Purity: >98%
  • GC65440 structure
    GC65440ddCTP trisodium
    Purity: >99.00%

    El ddCTP trisÓdico es uno de los 5'-trifosfatos de 2',3'-didesoxirribonucleÓsido (ddNTP) que actÚa como inhibidor de la cadena de la ADN polimerasa para la secuenciaciÓn del ADN.

  • GC65584 structure
    GC65584TMC310911
    CAS: 1000287-05-7
    Purity: >99.00%

    TMC310911 es un inhibidor de la proteasa del VIH tipo 1 (VIH-1) potente y activo por vÍa oral con valores de CE50 que oscilaron entre 2,2 nM y 14,2 nM para el VIH-1 de tipo salvaje.

  • GC66400 structure
    GC66400Hinokinin
    CAS: 26543-89-5
    Purity: >99.00%

    La hinoquinina (Compuesto 1) es un compuesto aislado de los tallos de Hypoestes aristate. La hinoquinina exhibe una actividad moderada de la enzima proteasa del VIH-1.

  • GC71023 structure
    GC71023CL-197
    CAS: 1030595-07-3
    Purity: >99.00%

    CL-197 es un inhibide la transcriptasa inversa (NRTI) de purina activa por vía oral y de acción prolongada.

  • GC71947 structure
    GC71947Acetyl-binankadsurin A
    CAS: 77174-33-5

    Acetyl-binankadsurin A (compuesto 5) es un Lignano aislado de Kadsura longipedunculata.

  • GC81868 structure
    GC81868Acetyl-pepstatin ammonium
    Purity: >98.00%

    Acetyl-pepstatin ammonium is an aspartic protease ( PRs ) inhibitor that targets HIV-1 protease and XMRV protease with K i values of 13 nM and 712 nM, respectively.

  • GN10545 structure
    GN10545Escin IA
    CAS: 123748-68-5
    Purity: >98.00%