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Lipoxygenase

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Lipoxygenases (LOXs) are dioxygenases that catalyze the formation of corresponding hydroperoxides from polyunsaturated fatty acids such as linoleic acid and arachidonic acid. Thre are six LOX isoforms have been found in the humans and mice. 5-Lipoxygenase (5-LOX) is a distinct isoform playing an important role in asthma and inflammation. 5-LOX causes the constriction of bronchioles in response to cysteinyl leukotrienes such as LTC4, thus leading to asthma. 5-LOX also induces neutrophilic inflammation by its recruitment in response to LTB4. 12-Lipoxygenase (12-LOX) is an isoform expressed in epithelial cells and myeloid cells including platelets. 12-LOX can be found in the epithelial cells of the skin. 12-LOX is a potential target for novel anti-platelet therapeutics.15-Lipoxygenase (15-LOX) is expressed in epithelial cells and leukocytes, has different substrate specificity in the humans and mice.15-LOX-1 is a target of nonsteroidal anti-inflammatory drug-induced apoptosis in colorectal cancer cells.

Products Related to Lipoxygenase(264)

  • GC49894 structure
    GC4989415(S)-HETE-d8 ethyl ester
    Purity: >99.00%

    An internal standard for the quantification of 15(S)-HETE ethyl ester

  • GC52105 structure
    GC52105Montelukast
    CAS: 158966-92-8
    Purity: >99.00%

    Montelukast (MK0476 base libre) es un antagonista potente, selectivo y activo por vÍa oral del receptor 1 de cisteinil leucotrieno (CysLT1).

  • GC52413 structure
    GC524135-Aminosalicylic Acid-d7
    Purity: >99.00%

    An internal standard for the quantification of 5-aminosalicylic acid

  • GC61180 structure
    GC61180Phenidone
    CAS: 92-43-3
    Purity: >98.00%

    La fenidona, un inhibidor dual activo por vÍa oral de la ciclooxigenasa (COX) y la lipoxigenasa (LOX), mejora la parÁlisis de ratas en la encefalomielitis autoinmune experimental.

  • GC62040 structure
    GC62040Cinnamyl-3,4-dihydroxy-α-cyanocinnamate
    CAS: 132465-11-3
    Purity: >99.50%

    Cinnamil-3,4-dihidroxi-α-cianocinamato (CDC) es un potente inhibidor de 12/15-lipoxigenasas (LO).

  • GC64078 structure
    GC640783-O-Acetyl-11-hydroxy-beta-boswellic acid
    CAS: 146019-25-2
    Purity: >98.00%

    El Ácido 3-O-acetil-11-hidroxi-beta-boswélico es un potente inhibidor de la 5-lipoxigenasa (5-LO).

  • GC64621 structure
    GC646214-Nitrocatechol
    CAS: 3316-09-4
    Purity: >98%

    El 4-nitrocatecol es un potente inhibidor de la lipoxigenasa.

  • GC66031 structure
    GC660315-LOX-IN-1
    CAS: 55040-82-9
    Purity: >98.00%

    5-LOX-IN-1 (compuesto 2b) es un inhibidor de la 5-lipoxigenasa humana (5-LOX) con un valor IC50 de 2,3 μM. 5-LOX-IN-1 se puede utilizar para la investigaciÓn de la inflamaciÓn.

  • GC68641 structure
    GC68641ALOX15-IN-1
    Purity: >98.00%

    ALOX15-IN-1 (compuesto 8b) es un inhibidor activo y selectivo de la actividad de la linoleato oxigenasa ALOX15 en conejos y humanos, con IC50 de 0.04 μM para el ácido linoleico (LA) y 2.06 μM para el ácido araquidónico (AA), ambos homólogos directos del ALOX15.

  • GC69335 structure
    GC69335KKII5
    CAS: 6381-55-1
    Purity: >98.00%

    KKII5 es un inhibidor efectivo de la lipoxigenasa LOX-1, con una IC50 de 19 μM. KKII5 inhibe la peroxidación lipídica.

  • GC69434 structure
    GC69434Masoprocol
    CAS: 27686-84-6
    Purity: >99.00%

    Masoprocol (ácido meso-Nordihidroguaiarético) es un inhibidor efectivo y con actividad oral de la lipoxigenasa. Masoprocol muestra actividad antihiperglucémica, reduciendo los niveles de glucosa en sangre y triglicéridos hepáticos. Masoprocol tiene potencial para investigar la diabetes tipo II.

  • GC70263 structure
    GC70263Tebufelone
    CAS: 112018-00-5
    Purity: >99.00%

    Tebufelone (NE-11740), un antiinflamatorio no esteroide(AINE), es un inhibiselectivo de la cox-2/5-lipoxigenasa.

  • GC70448 structure
    GC70448MLS000545091
    CAS: 322666-76-2
    Purity: >99.00%

    MLS000545091 es un potente y selectivo inhibide la lipoxigenasa-2 (LOX-2) con un valor de IC50 de 2.6 μM para h15-LOX-2.

  • GC72794 structure
    GC72794Flobufen
    CAS: 112344-52-2

    Flobufen (VUFB 16066) es un agente antiinflamno esteroidey un agente inhibide la ciclooxigen(COX) y la 5-lipoxigenasa (5-LOX).

  • GC74159 structure
    GC74159MK-0731
    CAS: 845256-65-7
    Purity: >99.00%

    MK-0731 es un inhibiselectivo, no competitivo y alostérico de la proteína del huso de cinesina (KSP) con una IC50 de 2,2 nM y una pKa de 7,6.

  • GC79706 structure
    GC797065-LOX-IN-9
    CAS: 2668-47-5
    Purity: >98.00%

    5-LOX-IN-9 is a 5-lipoxygenase and cyclooxygenase inhibitor, with an IC 50 of 0.2 pM against guinea pig 5-LOX and an IC 50 of 0.7 pM against bovine COX.

  • GC79757 structure
    GC79757ALOX5 stabilizer-1 TFA
    Purity: >98.00%

    ALOX5 stabilizer-1 TFA is an arachidonate 5-lipoxygenase ( ALOX5 ) stabilizer with a K d of 7.26 μM.

  • GC81543 structure
    GC81543GPX4-IN-19
    CAS: 3102894-57-2
    Purity: >99.00%

    GPX4-IN-19 is an effective GPX4 inhibitor ( IC 50 = 0.311 μM), covalently binds to the Sec 46 site of GPX4.

  • GC90533 structure
    GC90533(-)-Pinoresinol
    CAS: 81446-29-9
    Purity: >95.00%

    Un lignano con diversas actividades biológicas.

  • GC90652 structure
    GC9065212-oxo-9(Z)-Dodecenoic Acid
    CAS: 60485-39-4
    Purity: >95.00%

    Un metabolito del ácido linoleico y ácido linolénico.

  • GC91594 structure
    GC91594LYS-006 (hydrochloride)
    CAS: 2619563-79-8
    Purity: >98.00%

    LYS-006 is an inhibitor of leukotriene A4 (LTA4) hydrolase.

  • GC91613 structure
    GC91613FerroLOXIN-1
    CAS: 2773428-48-9
    Purity: >90.00%

    FerroLOXIN-1 is an inhibitor of the 15-lipoxygenase-2 (15-LO-2) and phosphatidylethanolamine-binding protein 1 (PEBP1) catalytic complex.

  • GN10269 structure
    GN10269Wedelolactone
    CAS: 524-12-9
    Purity: >99.50%
  • GN10792 structure
    GN10792Caffeic acid
    CAS: 331-39-5
    Purity: >98.50%

    Caffeic acid is a hydroxycinnamic acid polyphenol compound with antioxidant activity. Caffeic acid is an inhibitor of TRPV1 ion channel and 5-lipoxygenase.