DYRK

Mammalian DYRKs are a subfamily of mitogen-activated protein kinase-related protein kinases and are originally discovered on the basis of homology to the Saccharomyces cerevisiae Yak1 and Drosophila mini-brain kinases. DYRKs possess Ser/Thr phosphorylation activity as well as autophosphorylation activity on Tyr residue(s).

Two isoforms of DYRK, DYRK1A and DYRK1B, co-immunoprecipitate with HAN11 when coexpressed in COS cells indicating that the proteins interact in mammalian cells. Co-expression of DYRK1A, DYRK1B, or DYRK2 with a series of glycogen synthase mutants with Ser/Ala substitutions at the phosphorylation sites in COS cells revealed that protein kinases cause phosphorylation of site 3a in glycogen synthase. Control of glycogen synthase by DYRK represents a novel mechanism, and a potentially novel pathway, for the regulation of glycogen synthesis.

Products Related to DYRK(38)

GC70625 AnnH31
CAS: 241809-12-1
Purity: >99.00%
AnnH31 es un inhibidor de Dyrk1A (IC50: 81 nM).
GC70985 Dyrk1A-IN-3
CAS: 2493976-27-3
Purity: >99.00%
Dyrk1A-IN-3 (compuesto 8b), un inhibialtamente selectivo de doble especificidad de la tirosina quinasa regulada 1A (DYRK1A), mantiene altos niveles de afinidad de Unión a DYRK1A (IC50=76 nM).
GC71197 FINDY
CAS: 1507367-37-4
FINDY es un inhibidel plegado selectivo intermedio de DYRK1A.
GC72931 HTH-01-091 TFA
Purity: >98.00%
HTH-01-091 TFA es un potente y selectivo inhibide la cinasa (MELK), con una IC50 de 10,5 nM.
GC72982 BT173
CAS: 2232180-74-2
Purity: >98.00%
BT173 es un potente inhibide la proteína quinasa 2 (HIPK2) que interactúa con el homeodominio.
GC73224 CLK1-IN-3
CAS: 2922550-28-3
Purity: >98.00%
CLK1-IN-3 (compuesto 10ad) es un potente y selectivo inhibidor de Clk1, con una IC50 de 5 nM y más de 300 veces la selectividad para Dyrk1A.
GC73707 ON 108600
CAS: 1585246-23-6
Purity: >99.00%
ON 108600 es un inhibidor de CK2 (caseína quinase2)/TNIK/DYRK1, con los IC50 para DYRK1A/DYRKB, DYRK2, CK2 − 1/CK2 − 2, y TNIK de 0.016 − m/0.007 − m, 0.028 − m, 0.05 − m/ 0.005 − m, y 0.005 − m, respectivamente.
GC74165 4-(Trifluoromethyl)aniline-d4
CAS: 1219795-48-8
Purity: >99.00%
4-(Trifluoromethyl)aniline-d4 es deuterio marcado 4-trifluorometlanilina.
GC74261 (R)-(+)-O-Demethylbuchenavianine
CAS: 1364123-68-1
Purity: >98.00%
(R)-(+)-O-Demethylbuchenavianine es un inhibide las cinasas dependientes de ciclina CDK.
GC80874 ARN25699
Purity: >98%
ARN25699 is a kinase inhibitor with an IC 50 of 5.5 nM against GSK-3β, 2.2 nM against FYN-α, and 242.3 nM against DYRK1A, and it exhibits oral bioavailability.
GC81300 PROTAC DYRK2 degrader-2
CAS: 3061366-74-0
Purity: >98.00%
PROTAC DYRK2 degrader-2 is a PROTAC DYRK2 degrader based on curcumin analog A3.
GC81307 DYRK2-IN-2
CAS: 2416195-65-6
Purity: >98%
DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2, with its IC 50 value being 40.3 nM.
GC81308 DYRK2-IN-2 hydrochloride
Purity: >98.00%
DYRK2-IN-2 hydrochloride is a selective DYRK2 inhibitor with an IC 50 of 40.3 nM.
GC81309 AO-365/43472821
CAS: 1081122-55-5
Purity: >99.50%
AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A ( DYRK1A ) inhibitor ( IC 50 = 0.29 μM) and shows a significant inhibitory effect on ( CDC-like kinase 1) CLK1 ( IC 50 = 0.08 μM).

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC70625	AnnH31	241809-12-1	>99.00%
GC70625	AnnH31 es un inhibidor de Dyrk1A (IC50: 81 nM).
GC70985	Dyrk1A-IN-3	2493976-27-3	>99.00%
GC70985	Dyrk1A-IN-3 (compuesto 8b), un inhibialtamente selectivo de doble especificidad de la tirosina quinasa regulada 1A (DYRK1A), mantiene altos niveles de afinidad de Unión a DYRK1A (IC50=76 nM).
GC71197	FINDY	1507367-37-4	-
GC71197	FINDY es un inhibidel plegado selectivo intermedio de DYRK1A.
GC72931	HTH-01-091 TFA	-	>98.00%
GC72931	HTH-01-091 TFA es un potente y selectivo inhibide la cinasa (MELK), con una IC50 de 10,5 nM.
GC72982	BT173	2232180-74-2	>98.00%
GC72982	BT173 es un potente inhibide la proteína quinasa 2 (HIPK2) que interactúa con el homeodominio.
GC73224	CLK1-IN-3	2922550-28-3	>98.00%
GC73224	CLK1-IN-3 (compuesto 10ad) es un potente y selectivo inhibidor de Clk1, con una IC50 de 5 nM y más de 300 veces la selectividad para Dyrk1A.
GC73707	ON 108600	1585246-23-6	>99.00%
GC73707	ON 108600 es un inhibidor de CK2 (caseína quinase2)/TNIK/DYRK1, con los IC50 para DYRK1A/DYRKB, DYRK2, CK2 − 1/CK2 − 2, y TNIK de 0.016 − m/0.007 − m, 0.028 − m, 0.05 − m/ 0.005 − m, y 0.005 − m, respectivamente.
GC74165	4-(Trifluoromethyl)aniline-d4	1219795-48-8	>99.00%
GC74165	4-(Trifluoromethyl)aniline-d4 es deuterio marcado 4-trifluorometlanilina.
GC74261	(R)-(+)-O-Demethylbuchenavianine	1364123-68-1	>98.00%
GC74261	(R)-(+)-O-Demethylbuchenavianine es un inhibide las cinasas dependientes de ciclina CDK.
GC80874	ARN25699	-	>98%
GC80874	ARN25699 is a kinase inhibitor with an IC 50 of 5.5 nM against GSK-3β, 2.2 nM against FYN-α, and 242.3 nM against DYRK1A, and it exhibits oral bioavailability.
GC81300	PROTAC DYRK2 degrader-2	3061366-74-0	>98.00%
GC81300	PROTAC DYRK2 degrader-2 is a PROTAC DYRK2 degrader based on curcumin analog A3.
GC81307	DYRK2-IN-2	2416195-65-6	>98%
GC81307	DYRK2-IN-2 (Compound C17) is a selective inhibitor of DYRK2, with its IC 50 value being 40.3 nM.
GC81308	DYRK2-IN-2 hydrochloride	-	>98.00%
GC81308	DYRK2-IN-2 hydrochloride is a selective DYRK2 inhibitor with an IC 50 of 40.3 nM.
GC81309	AO-365/43472821	1081122-55-5	>99.50%
GC81309	AO-365/43472821 is a selective, brain-penetrant Dual-specificity tyrosine phosphorylation-regulated kinase 1A ( DYRK1A ) inhibitor ( IC 50 = 0.29 μM) and shows a significant inhibitory effect on ( CDC-like kinase 1) CLK1 ( IC 50 = 0.08 μM).