SABA1 possesses antibacterial properties against Pseudomonas aeruginosa and Escherichia coli, with an IC50 of 4.0 µM against E. coli ACC.
SABA1 inhibits BC via an atypical mechanism. It binds in the biotin binding site in the presence of ADP and represents a potentially antibiotic used to combat the antibacterial resistance crisis[1].
References:
[1]. Matthew K Craft, et al. Mechanism of biotin carboxylase inhibition by ethyl 4-[[2-chloro-5-(phenylcarbamoyl)phenyl]sulphonylamino]benzoate. J Enzyme Inhib Med Chem. 2022 Dec;37(1):100-108.