Other Signal Transduction

GATA4-NKX2-5-IN-1 (3i-1000) is a small-molecule compound inhibiting GATA4 and NKX2-5 transcriptional synergy with IC50 of 3 uM

Panx-1 mimetic inhibitory peptide, blocks pannexin-1 gap junctions

Eeyarestatin I, un potente inhibidor de la degradación de proteínas asociada al retículo endoplásmico (ERAD), es un inhibidor eficaz de la translocación de proteínas. Perturba la homeostasis del retículo endoplásmico (RE) y tiene actividades anticancerígenas similares a las del Bortezomib. Eeyarestatin I inhibe el translocón Sec61.

10Panx is a potent Panx1 channel inhibitor that targets the W74 to Y83 segment of the ECL1 of Panx1 protein.

El levetiracetam, un agente antiepiléptico, se une a la proteÍna de la vesÍcula sinÁptica SV2A.

BLU-782 es una terapia de precisión oral diseñada específicamente para atacar selectivamente el mutante ALK2.

M2N12 es un inhibidor potente y altamente selectivo de la proteÍna fosfatasa 25C (Cdc25C) del ciclo de divisiÓn celular con un valor IC50 de 0,09 μM. M2N12 también tiene una actividad prometedora contra Cdc25A y Cdc25B con valores IC50 de 0,53 μM y 1,39 μM, respectivamente. M2N12 tiene actividad antitumoral y puede usarse para la investigaciÓn del cÁncer.

LP-935509 es un inhibidor oralmente activo, potente, selectivo, competitivo con ATP y que penetra en el cerebro del quinasa asociada a la proteína adaptadora 2 (AAK1) con un IC50 de 3.3 nM y un Ki de 0.9 nM, respectivamente.

Decursinol angelate is a pyranocoumarin that has been found in the Korean medicinal herb A.

Compound 43 TAO kinase inhibitor is an ATP-competitive inhibitor of the thousand-and-one amino acid kinases TAOK1 and TAOK2 (IC50s = 11 and 15 nM, respectively).

Protein kinase D (PKD) is a serine/threonine protein kinase that is activated by diacylglycerol, commonly downstream of PKC signaling.

D-myo-inositol-1,2,3,5,6-pentaphosphate (Ins(1,2,3,5,6)-P5) (sodium salt) is produced from Ins(1,2,3,4,5,6)P6 via a minor enzymatic phytate degradation pathway by K.

D-myo-Inositol-1,2,3,5-tetraphosphate (Ins(1,2,3,5)P4) is one of the many inositol phosphate isomers that could act as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,2,4,5,6-pentaphosphate (sodium salt) (Ins(1,2,4,5,6)P5 (sodium salt)) is one of several different inositol oligophosphate isomers implicated in signal transduction.

Ins(1,2,4,5)P4 is one of the many inositol phosphate (InsP) isomers that act as small, soluble second messengers in the transmission of cellular signals..

D-myo-Inositol-1,2,6-phosphate (Ins(1,2,6)-P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

The phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway plays critical roles in cell growth and proliferation making it an attractive target for anticancer agents.

The inositol phosphates play a critical role as small, soluble second messengers in transmission of cellular signals.

D-myo-Inositol-1,3,5-phosphate (Ins(1,3,5)P3) is a member of the inositol phosphate (InsP) family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-Inositol-1,4-phosphate (Ins(1,4)P2) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,5-phosphate (Ins(1,5)P) is a member of the inositol phosphate (InsP) molecular family that play critical roles as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate molecular family of second messengers that play critical roles in intracellular signaling.

D-myo-Inositol-1-phosphate (Ins(1)P1) is a member of the inositol phosphate (InsP) molecular family of second messengers that play a critical role in the transmission of cellular signals.

D-myo-inositol-2,3,5,6-tetraphosphate (sodium salt) (Ins(2,3,5,6)-P4 (sodium salt)) is produced from Ins(1,2,3,5,6)P5 via a minor enzymatic phytate degradation pathway by K.