SMS121 is a CD36 inhibitor. By targeting the lipid uptake protein CD36, SMS121 blocks the pathway of fatty acid entry into AML cells to reduce the uptake of fatty acids by AML cells, thereby reducing the activity of these cells. SMS121 can be used to study acute myeloid leukemia (AML).
References:
[1]. Åbacka H, et al. SMS121, a new inhibitor of CD36, impairs fatty acid uptake and viability of acute myeloid leukemia[J]. Scientific Reports, 2024, 14(1): 9104.