GLPBio

VU6052254

Catalog No.: GC79315Purity:>98.00%
COASDSData Sheet
VU6052254, a derivative of VU0467319, is a selective, potent, orally active and brain-penetrant muscarinic M1 acetylcholine receptor ( mAChR1 ) positive allosteric modulator with an EC 50 of 59 nM.

Los productos son exclusivamente para uso en investigación. No aptos para uso humano. No vendemos a pacientes.

VU6052254
Cas No.: 3035701-02-8
10mM (in 1mL DMSO)In Stock
$290.00
1
5mgIn Stock
$263.00
1
10mgIn Stock
$421.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citas (Citations)

Actualmente no hay citas disponibles para este producto. A continuación se muestran publicaciones seleccionadas que citan productos GlpBio.
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    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Descripción (Description)

VU6052254, a derivative of VU0467319, is a selective, potent, orally active and brain-penetrant muscarinic M1 acetylcholine receptor ( mAChR1 ) positive allosteric modulator with an EC 50 of 59 nM. VU6052254 has no activity on the M2-5 receptor ( EC 50 > 30 μM). VU6052254 can improve memory recognition ability and reverse the cognitive impairment induced by Scopolamine with minimum effective dose both of 1 mg/kg. VU6052254 can be used for the research of neurological disease, such as Alzheimer's disease [1].

References:
[1]. Engers JL, et al. Discovery of VU6052254: A Novel, Potent M1 Positive Allosteric Modulator. ACS Chem Neurosci. 2025 Dec 17;16(24):4741-4750.

Documentos del producto (Product Documents)

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Propiedades químicas (Chemical Properties)

N.º CAS
3035701-02-8
Fórmula molecular
C25H22F2N4O2
Peso molecular
448.46
Solubilidad
DMSO: 33.33 mg/mL (74.32 mM; Need ultrasonic)
Almacenamiento
Store at -20°C
Condiciones de envío
Las muestras de evaluación se envían con acumuladores de frío. Los demás tamaños se envían a temperatura ambiente o, previa solicitud, con acumuladores de frío.

Calculadoras (Calculators)Molaridad / Dilución / Peso molecular / Conversión de unidades / Formulación in vivo / Solubilidad

g/mol

Reviews

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