Zearalanone |
Catalog No.GC10684
One-Click Copy Product Info
|
La zearalenona es una micotoxina estrogénica no esteroide producida por especies de Fusarium, que coloniza varios granos.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 5975-78-0
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
Zearalanone (ZAN) is an estrogen receptor agonist and also an androgen receptor antagonist [1].
Zearalenone (ZEN), a β-resorcyclic acid lactone (RAL), is a non-steroidal estrogenic mycotoxin biosynthesized by several Fusarium species. Zearalenone (ZEN) is the well-known mycotoxin present in numerous agricultural products [1][2][3][4]. In the human endometrial Ishikawa cell line, zearalenone (ZEN) exhibited strong oestrogenicity [4].When incubated Fusarium semitectum on sorghum, the ratio of ZAN to ZEN remained constant after 5 days, suggesting that ZAN might not be suitable for use as an internal standard [5].
Zearalanone, a major phase I metabolite of zearalenone (ZEN), is an estrogen receptor agonist and also an androgen receptor antagonist. In MCF-7 cells, Zearalanone strongly induced cell proliferation with EC50 value of 1.21 nM and showed significant estrogenic activity. Zearalanone behaved as full hERα agonist. In PALM cells, Zearalanone acted as a hAR antagonist that strongly inhibited the luciferase activity induced by 0.3 nM of R1881, the synthetic androgen [1].
References:
[1]. Molina-Molina JM, Real M, Jimenez-Diaz I, et al. Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays. Food Chem Toxicol.2014 Dec;74:233-9.
[2]. Baldwin RS, Williams RD, Terry MK. Zeranol: a review of the metabolism, toxicology, and analytical methods for detection of tissue residues. Regul Toxicol Pharmacol. 1983 Mar;3(1):9-25.
[3]. Migdalof BH, Dugger HA, Heider JG, et al. Biotransformation of zeranol: disposition and metabolism in the female rat, rabbit, dog, monkey and man. Xenobiotica. 1983 Apr;13(4):209-21.
[4]. Le Guevel R, Pakdel F. Assessment of oestrogenic potency of chemicals used as growth promoter by in-vitro methods. Hum Reprod. 2001 May;16(5):1030-6.
[5]. Aoyama K, Ishikuro E, Noriduki H, et al. Formation Ratios of Zearalanone, Zearalenols, and Zearalanols versus Zearalenone during Incubation of Fusarium semitectum on Sorghum and Ratios in Naturally Contaminated Sorghum. Shokuhin Eiseigaku Zasshi. 2015;56(6):247-51.
| Cas No. | 5975-78-0 | SDF | |
| Chemical Name | (3S)-3,4,5,6,9,10,11,12-octahydro-14,16-dihydroxy-3-methyl-1H-2-benzoxacyclotetradecin-1,7(8H)-dione | ||
| Canonical SMILES | OC1=C(C(O[C@@H](C)CCCC(CCCCC2)=O)=O)C2=CC(O)=C1 | ||
| Formula | C18H24O5 | M.Wt | 320.4 |
| Solubility | DMSO : 100 mg/mL (312.13 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.1211 mL | 15.6055 mL | 31.211 mL |
| 5 mM | 624.2 μL | 3.1211 mL | 6.2422 mL |
| 10 mM | 312.1 μL | 1.5605 mL | 3.1211 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)