ZY-2 (solution) is a fluorescent probe targeting pyruvate kinase M2 ( PKM2 ) with an excitation wavelength of 419 nm. ZY-2 (solution) significantly activates purified PKM2 protein. ZY-2 (solution) exhibits enhanced fluorescence emission in low-polarity or high-viscosity environments. ZY-2 (solution) enables highly sensitive and selective fluorescence imaging of PKM2 in live PKM2 -positive cancer cells, with no significant side effects on cell viability within its effective concentration range. ZY-2 (solution) can be used for cervical cancer research [1]. Solvent and concentration: DMSO: 10 mM
In Vitro, ZY-2 (1 μM) significantly activates the pyruvate kinase activity of purified PKM2 protein, reaching a relative activity of ~800%[1].
References:
[1]. Zhang Y, et al. A responsive fluorescent probe for detecting and imaging pyruvate kinase M2 in live cells. Chemical communications (Cambridge, England). 2022 Jun 01;58(45):6494-6497.
In Vitro, ZY-2 (1 μM) significantly activates the pyruvate kinase activity of purified PKM2 protein, reaching a relative activity of ~800%[1].
References:
[1]. Zhang Y, et al. A responsive fluorescent probe for detecting and imaging pyruvate kinase M2 in live cells. Chemical communications (Cambridge, England). 2022 Jun 01;58(45):6494-6497.