GLPBio

SR12418

Catalog No.: GC71019Purity:>99.50%
COASDSData Sheet
SR12418 is a REV-ERB-specific synthetic ligand with IC50s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively.

Products are for research use only. Not for human use. We do not sell to patients.

SR12418
Cas No.: 1801185-08-9
10mM (in 1mL DMSO)In Stock
$201.00
1
5 mgIn Stock
$189.00
1
10 mgIn Stock
$315.00
1
25 mgIn Stock
$630.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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Description

SR12418 is a REV-ERB-specific synthetic ligand with IC50s of 68 nM and 119 nM for REV-ERBα and REV-ERBβ, respectively. SR12418 can be used in experimental autoimmune encephalomyelitis (EAE) and colitis research.

SR12418 (5 μM; 96 h) inhibits the growth of TH17 cells[1].
SR12418 (5 and 10 μM; 4 d) inhibits cell differentiation under TH17 polarizing conditions[1].

SR12418 (intraperitoneal injection; 50 mg/kg; twice a day) suppresses the development and severity of experimental autoimmune encephalomyelitis[1].
SR12418 (intraperitoneal injection; 50 mg/kg; twice a day; begin at day 18 post-immunization) shows effects in intervention studies of relapsing-remitting experimental autoimmune encephalomyelitis[1].

References:
[1]. Mohammed Amir, et al. REV-ERBα Regulates TH17 Cell Development and Autoimmunity. Cell Rep. 2018 Dec 26;25(13):3733-3749.e8.
[2]. Shuai Wang, et al. Targeting REV-ERBα for therapeutic purposes: promises and challenges. Theranostics. 2020 Mar 4;10(9):4168-4182.

Product Documents

Purity:>99.50%Appearance:A solid
COASDSData Sheet

Chemical Properties

CAS No.
1801185-08-9
Molecular Formula
C31H30FNO3
Molecular Weight
483.57
Solubility
DMSO : 100 mg/mL (206.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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