GLPBio

ST45177901

Catalog No.: GC79216Purity:>98%
COASDSData Sheet
ST45177901 is a CC chemokine receptor 4 ( CCR4 ) antagonist.

Products are for research use only. Not for human use. We do not sell to patients.

ST45177901
Cas No.: 618865-88-6
1mgIn Stock
$219.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
  • Science cover
    Science
    388(6745) (2025)
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    Science
    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    Cell Research
    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

ST45177901 is a CC chemokine receptor 4 ( CCR4 ) antagonist. The combination of ST45177901 and Sorafenib effectively inhibits the chemotaxis of Treg cells via the CCL22/CCL17-CCR4 signaling pathway, thereby significantly suppressing the growth and metastasis of tumor cells. ST45177901 is applicable to liver cancer research [1].

In Vivo, ST45177901 exhibits effects similar to those of C-021 (C-021, when combined with Sorafenib, effectively inhibits hepatocellular carcinoma growth) in mice[1].

References:
[1]. Yang, et al. Application of sorafenib combined with CCR4 antagonist for restraining cancer growth and transfer. CN106421796A. China. 2016-11-02.

Chemical Properties

CAS No.
618865-88-6
Molecular Formula
C26H16ClN3O4S3
Molecular Weight
566.07
Storage
Store at -20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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