GLPBio

TREM2 agonist-3

Catalog No.: GC78701Purity:>99.00%
COASDSData Sheet
TREM2 agonist-3 (Compound 4i) is aTREM2agonist, with aKDvalue of 19.0 ?M.

Products are for research use only. Not for human use. We do not sell to patients.

TREM2 agonist-3
5mgIn Stock
$423.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

Citations

No citations are currently available for this product. Below are selected publications citing GlpBio products.
  • Nature cover
    Nature
    641, 529–536 (2025)
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    Nature
    628, 630–638 (2024)
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    Nature
    632, 686–694 (2024)
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    Nature
    618, 1017–1023 (2023)
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    Nature
    610, 366–372 (2022)
  • Cell cover
    Cell
    187(9):2288-2304 (2024)
  • Cell cover
    Cell
    183(7):1867-1883 (2020)
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    Science
    388(6745) (2025)
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    387(6739) (2025)
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    Science
    387(6734) (2025)
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    Cell Research
    35, 97–116 (2025)
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    Cell Research
    34, 683–706 (2024)
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    33, 273–287 (2023)
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    33, 546–561 (2023)
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    33, 904–922 (2023)
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    Cell Research
    31, 1291–1307 (2021)

Description

TREM2 agonist-3 (Compound 4i) is aTREM2agonist, with aKDvalue of 19.0 ?M. TREM2 agonist-3 shows aKDvalue of 39.8 ?M forTREM1. TREM2 agonist-3 induces an increase inphospho-SYKlevels. TREM2 agonist-3 can be used in the research of neurodegenerative diseases andother diseasesinvolving TREM2 dysfunction[1].

References:
[1].Nada H, et al. TREM2 Activation by First-in-Class Direct Small Molecule Agonists: DEL Screening, Optimization, Biophysical Validation, and Functional Characterization. bioRxiv [Preprint]. 2025 May 27:2025.05.22.655617.

Product Documents

Purity:>99.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C21H22N2O4S
Molecular Weight
398.48
Solubility
DMSO: 100 mg/mL(250.95 mM; Need ultrasonic)
Storage
-20°C
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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