IF 45
PMID: 39977546 ↗dADP disodium (2'-Deoxyadenosine 5'-di-phos-phate disodium)
Catalog No.: GC11854Purity:>98%Synonyms: dADP 2'-deoxy-ADP
dADP disodium (2'-Deoxyadenosine 5'-di-phos-phate disodium) is a purine nucleotide diphosphate related to ADP and dATP.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 72003-83-9
1mgIn Stock
$20.00
1
5mgIn Stock
$46.00
1
10mgIn Stock
$68.00
1
25mgIn Stock
$112.00
1
50mgIn Stock
$167.00
1
100mgIn Stock
$248.00
1
| Pack Size | Price | Availability | Quantity | Action |
|---|---|---|---|---|
| 1mg | $20.00 | In Stock | 1 | |
| 5mg | $46.00 | In Stock | 1 | |
| 10mg | $68.00 | In Stock | 1 | |
| 25mg | $112.00 | In Stock | 1 | |
| 50mg | $167.00 | In Stock | 1 | |
| 100mg | $248.00 | In Stock | 1 |
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Citations
1 publicationsPublications from researchers using this productDescription
dADP disodium (2'-Deoxyadenosine 5'-di-phos-phate disodium) is a purine nucleotide diphosphate related to ADP and dATP[1]. dADP disodium can act as a substrate analog and inhibitor in polynucleotide phosphorylase reactions, including inhibition of Adenosine diphosphate(ADP) and Cytidine diphosphate(CDP) polymerization at 0.23mM in bacterial enzyme systems[1,2]. dADP disodium is used in research on nucleotide metabolism, polymerase and phosphorylase specificity, purinergic cell responses, and insect chemosensory feeding assays[1-5].
In vitro, human platelet-rich plasma exposed to dADP disodium (7μg/mL; single addition) showed platelet-aggregating activity. On a weight basis, its activity was approximately 0.3% of that of ADP, supporting its use as a deoxy-nucleotide probe in platelet-response research[3].
In vivo, adult female Culex pipiens and Culiseta inornata were tested in artificial feeding assays with dADP disodium (1mM; single artificial-diet exposure). dADP disodium produced a weaker phagostimulatory response than ADP[4].
References:[1] Lucas-Lenard JM, Cohen SS. The inhibition of polynucleotide phosphorylase by certain substrate analogues. Biochim Biophys Acta. 1966;123(3):471-477. doi:10.1016/0005-2787(66)90209-0.
[2] Chou JY, Singer MF. Deoxyadenosine diphosphate as a substrate and inhibitor of polynucleotide phosphorylase of Micrococcus luteus. II. Inhibition of the initiation of adenosine diphosphate polymerization by deoxyadenosine diphosphate. J Biol Chem. 1971;246(24):7497-7504.
[3] Gaarder A, Laland S. Hypothesis for the aggregation of platelets by nucleotides. Nature. 1964;202:909-910. doi:10.1038/202909a0.
[4] Galun R, Friend WG, Nudelman S. Purinergic reception by culicine mosquitoes. J Comp Physiol A. 1988;163:665-670. doi:10.1007/BF00603850.
[5] Yazawa S, Tsuchiya H, Hori H, Makino R. Functional characterization of two nucleotide-binding sites in soluble guanylate cyclase. J Biol Chem. 2006;281(31):21763-21770. doi:10.1074/jbc.M602790200.
Protocol
| Cell experiment [1]: | |
|
Cell lines |
Human platelet-rich plasma |
|
Preparation Method |
Human platelet-rich plasma was placed in an aggregation assay system and exposed once to dADP disodium (2’-Deoxyadenosine 5’-di-phos-phate disodium). The aggregation response was recorded and compared with the response to ADP. |
|
Reaction Conditions |
7μg/mL |
|
Applications |
The 7μg/mL condition induced platelet aggregation; on a weight basis, its aggregating activity was approximately 0.3% of that of ADP. |
| References: [1] Gaarder A, Laland S. Hypothesis for the aggregation of platelets by nucleotides. Nature. 1964;202:909-910. doi:10.1038/202909a0. [2] Galun R, Friend WG, Nudelman S. Purinergic reception by culicine mosquitoes. J Comp Physiol A. 1988;163:665-670. doi:10.1007/BF00603850. | |
Product Documents
Purity:>98%Appearance:A solid
Chemical Properties
CAS No.
72003-83-9
Synonyms
dADP 2'-deoxy-ADP
Chemical Name
((2R,3S,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxytetrahydrofuran-2-yl)methyl trihydrogen diphosphate
SMILES
[Na+].[Na+].Nc1ncnc2n(cnc12)[C@H]1C[C@H](O)[C@@H](COP([O-)(=O)OP(O)([O-1)=O)01
Molecular Formula
C10H13N5Na2O9P2
Molecular Weight
455.17
Solubility
H2O: 125 mg/mL (274.62 mM), Sonication is recommended.
Storage
Store at -20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.
CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility
g/mol
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