3-Hydroxyproline is a non-glycosyl microbial α-glucosidase inhibitor. 3-Hydroxyproline is used in the research of diabetes (type 2 diabetes/non-insulin-dependent diabetes mellitus) [1].
In Vitro, 3-Hydroxyproline (Compound 2) (1.5 mg/mL; 20 min pre-incubation, 40 min reaction incubation) potently inhibits Saccharomyces cerevisiae α-glucosidase (IC50 = 5.3 μg/mL), effectively inhibits rat intestinal α-glucosidase (IC50 = 100 μg/mL) and Bacillus stearothermophilus α-glucosidase (IC50 = 142 μg/mL), and shows no activity against rice α-glucosidase[1].
References:
[1]. Van Bon Nguyen, et al. New novel α–glucosidase inhibitors produced by microbial conversion. Process Biochemistry (2017).
In Vitro, 3-Hydroxyproline (Compound 2) (1.5 mg/mL; 20 min pre-incubation, 40 min reaction incubation) potently inhibits Saccharomyces cerevisiae α-glucosidase (IC50 = 5.3 μg/mL), effectively inhibits rat intestinal α-glucosidase (IC50 = 100 μg/mL) and Bacillus stearothermophilus α-glucosidase (IC50 = 142 μg/mL), and shows no activity against rice α-glucosidase[1].
References:
[1]. Van Bon Nguyen, et al. New novel α–glucosidase inhibitors produced by microbial conversion. Process Biochemistry (2017).