Home >> Signaling Pathways >> Proteases


Proteases is a general term for a class of enzymes that hydrolyze protein peptide chains. According to the way they degrade polypeptides, they are divided into two categories: endopeptidases and telopeptidases. The former can cut the large molecular weight polypeptide chain from the middle to form prions and peptones with smaller molecular weights; the latter can be divided into carboxypeptidase and aminopeptidase, which respectively remove the peptide from the free carboxyl terminus or free amino terminus of the polypeptide one by one. Chain hydrolysis produces amino acids.

A general term for a class of enzymes that hydrolyze peptide bonds in proteins. According to the way they hydrolyze polypeptides, they can be divided into endopeptidases and exopeptidases. Endopeptidase cleaves the interior of the protein molecule to form smaller molecular weight peptones and peptones. Exopeptidase hydrolyzes peptide bonds one by one from the end of the free amino group or carboxyl group of protein molecules, and frees amino acids, the former is aminopeptidase and the latter is carboxypeptidase. Proteases can be classified into serine proteases, sulfhydryl proteases, metalloproteases and aspartic proteases according to their active centers and optimum pH. According to the optimum pH value of its reaction, it is divided into acidic protease, neutral protease and alkaline protease. The proteases used in industrial production are mainly endopeptidases.

Proteases are widely found in animal offal, plant stems and leaves, fruits and microorganisms. Microbial proteases are mainly produced by molds and bacteria, followed by yeast and actinomycetes.

Enzymes that catalyze the hydrolysis of proteins. There are many kinds, the important ones are pepsin, trypsin, cathepsin, papain and subtilisin. Proteases have strict selectivity for the reaction substrates they act on. A protease can only act on certain peptide bonds in protein molecules, such as the peptide bonds formed by the hydrolysis of basic amino acids catalyzed by trypsin. Proteases are widely distributed, mainly in the digestive tract of humans and animals, and are abundant in plants and microorganisms. Due to limited animal and plant resources, the industrial production of protease preparations is mainly prepared by fermentation of microorganisms such as Bacillus subtilis and Aspergillus terrestris.

Products for  Proteases

  1. Cat.No. Product Name Information
  2. GC26092 Z-LEHD-FMK TFA Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival. Z-LEHD-FMK TFA  Chemical Structure
  3. GC26017 UK-371804 HCl UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin). UK-371804 HCl  Chemical Structure
  4. GC25727 PF-06446846 PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region. PF-06446846  Chemical Structure
  5. GC25726 PF-05221304 PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL). PF-05221304  Chemical Structure
  6. GC25723 Perindopril L-Arginine Perindopril L-Argininel is a prodrug that is metabolized in the liver to its active diacid metabolite perindoprilat, which is rapidly and extensively absorbed, and become one of the highest tissue angiotensin-converting enzyme (ACE) affinities among the ACE inhibitors. Perindopril L-Arginine  Chemical Structure
  7. GC25536 JHU395 JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity. JHU395  Chemical Structure
  8. GC25337 D-Carnitine hydrochloride D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids. D-Carnitine hydrochloride  Chemical Structure
  9. GC25188 Calcium 2-oxoglutarate Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM. Calcium 2-oxoglutarate  Chemical Structure
  10. GC25117 Azvudine Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM). Azvudine  Chemical Structure
  11. GC68478 Bictegravir sodium Bictegravir sodium  Chemical Structure
  12. GC68468 MPO-IN-3 MPO-IN-3  Chemical Structure
  13. GC68464 ALDH1A3-IN-1 ALDH1A3-IN-1  Chemical Structure
  14. GC68462 ALDH1A3-IN-2 ALDH1A3-IN-2  Chemical Structure
  15. GC68453 ITMN 4077 ITMN 4077  Chemical Structure
  16. GC68450 Hsp90-IN-17 hydrochloride Hsp90-IN-17 hydrochloride  Chemical Structure
  17. GC68426 17a-Hydroxypregnenolone-d3 17a-Hydroxypregnenolone-d3  Chemical Structure
  18. GC68421 L-Aspartic acid-13C4,15N L-Aspartic acid-13C4,15N  Chemical Structure
  19. GC68417 Homovanillic acid-d5 Homovanillic acid-d5  Chemical Structure
  20. GC68415 Glycolic acid-d2 Glycolic acid-d2  Chemical Structure
  21. GC68414 (Rac)-Atropine-d3 (Rac)-Atropine-d3  Chemical Structure
  22. GC68399 Isolindleyin Isolindleyin  Chemical Structure
  23. GC68395 L-Isoleucine-d10 L-Isoleucine-d10  Chemical Structure
  24. GC68387 FGN849 FGN849  Chemical Structure
  25. GC68384 DL-Mevalonolactone-d7 DL-Mevalonolactone-d7  Chemical Structure
  26. GC68382 L-Cysteine-1-13C L-Cysteine-1-13C  Chemical Structure
  27. GC68380 Sarcosine-15N Sarcosine-15N  Chemical Structure
  28. GC68375 Cholic acid-13C Cholic acid-13C  Chemical Structure
  29. GC68374 5a-Pregnane-3,20-dione-d6 5a-Pregnane-3,20-dione-d6  Chemical Structure
  30. GC68351 DL-Homocysteine-d4 DL-Homocysteine-d4  Chemical Structure
  31. GC68329 Normetanephrine-d3 hydrochloride Normetanephrine-d3 hydrochloride  Chemical Structure
  32. GC68324 3-Methoxytyramine-d4 hydrochloride 3-Methoxytyramine-d4 hydrochloride  Chemical Structure
  33. GC68310 S-Adenosyl-L-methionine-d3 S-Adenosyl-L-methionine-d3  Chemical Structure
  34. GC68302 AS-Inclisiran AS-Inclisiran  Chemical Structure
  35. GC68228 5-Nitro-1,10-phenanthroline 5-Nitro-1,10-phenanthroline  Chemical Structure
  36. GC68218 Mepazine Mepazine  Chemical Structure
  37. GC68216 L-Valine-1-13C L-Valine-1-13C  Chemical Structure
  38. GC68215 Glycine-1-13C Glycine-1-13C  Chemical Structure
  39. GC68214 DL-Alanine-13C-1 DL-Alanine-13C-1  Chemical Structure
  40. GC68150 BC-1382 BC-1382  Chemical Structure
  41. GC68149 L-Serine-15N L-Serine-15N  Chemical Structure
  42. GC68148 L-Tyrosine-d2 L-Tyrosine-d2  Chemical Structure
  43. GC68143 L-Methionine-1-13C L-Methionine-1-13C  Chemical Structure
  44. GC68142 D-Phenylalanine-d5 D-Phenylalanine-d5  Chemical Structure
  45. GC68097 Acetyl-L-carnitine-d3 hydrochloride Acetyl-L-carnitine-d3 hydrochloride  Chemical Structure
  46. GC68082 3,4,5-Trimethoxyphenylacetic acid 3,4,5-Trimethoxyphenylacetic acid  Chemical Structure
  47. GC68055 4-Hydroxyphenyl acetate 4-Hydroxyphenyl acetate  Chemical Structure
  48. GC68053 L-Tyrosine-1-13C L-Tyrosine-1-13C  Chemical Structure
  49. GC68052 Pyruvic acid 13C sodium Pyruvic acid 13C sodium  Chemical Structure
  50. GC68049 L-Aspartic acid-1,4-13C2 L-Aspartic acid-1,4-13C2  Chemical Structure
  51. GC68042 DL-Homocystine-3,3,3',3',4,4,4',4'-d8 DL-Homocystine-3,3,3',3',4,4,4',4'-d8  Chemical Structure
  52. GC68038 L-Tyrosine D4 L-Tyrosine D4  Chemical Structure
  53. GC68022 L-Methionine-15N L-Methionine-15N  Chemical Structure
  54. GC68020 L-Glutamic acid-1-13C L-Glutamic acid-1-13C  Chemical Structure
  55. GC68013 CDE-096 CDE-096  Chemical Structure
  56. GC68009 KS106 KS106  Chemical Structure
  57. GC68008 GÜ2602 GÜ2602  Chemical Structure
  58. GC67997 Aminopeptidase-IN-1 Aminopeptidase-IN-1  Chemical Structure
  59. GC67993 (Rac)-Cotinine-d4 (Rac)-Cotinine-d4  Chemical Structure
  60. GC67992 MLT-747 MLT-747  Chemical Structure
  61. GC67988 6-Hydroxybenzbromarone 6-Hydroxybenzbromarone  Chemical Structure
  62. GC67978 Paltimatrectinib Paltimatrectinib  Chemical Structure
  63. GC67976 D-Glucose-13C D-Glucose-13C  Chemical Structure
  64. GC67975 Hexacosanoic acid-d4-1 Hexacosanoic acid-d4-1  Chemical Structure
  65. GC67973 L-Alanine-13C2 L-Alanine-13C2  Chemical Structure
  66. GC67952 Hippuric acid-d5 Hippuric acid-d5  Chemical Structure
  67. GC67951 5-Hydroxytryptophol-d4 5-Hydroxytryptophol-d4  Chemical Structure
  68. GC67947 Triolein 13C3 Triolein 13C3  Chemical Structure
  69. GC67942 Stearic acid-d3 Stearic acid-d3  Chemical Structure
  70. GC67918 MPO-IN-1 MPO-IN-1  Chemical Structure
  71. GC67916 Palmitic acid-d4 Palmitic acid-d4  Chemical Structure
  72. GC67911 L-Serine-1-13C L-Serine-1-13C  Chemical Structure
  73. GC67910 L-Citrulline-13C L-Citrulline-13C  Chemical Structure
  74. GC67902 3-Amino-2-oxazolidinone-d4 3-Amino-2-oxazolidinone-d4  Chemical Structure
  75. GC67898 GLS-1-IN-1 GLS-1-IN-1  Chemical Structure
  76. GC67835 Glycocholic acid sodium Glycocholic acid sodium  Chemical Structure
  77. GC67782 ALDH1A2-IN-1 ALDH1A2-IN-1  Chemical Structure
  78. GC67781 Diaplasinin Diaplasinin  Chemical Structure
  79. GC67771 GSK321 GSK321  Chemical Structure
  80. GC67766 Abiraterone sulfate Abiraterone sulfate  Chemical Structure
  81. GC67761 (Z)-10-Hydroxynortriptyline-d3 (Z)-10-Hydroxynortriptyline-d3  Chemical Structure
  82. GC67751 Berotralstat dihydrochloride Berotralstat dihydrochloride  Chemical Structure
  83. GC67731 S-(2-Carboxypropyl)-L-cysteine S-(2-Carboxypropyl)-L-cysteine  Chemical Structure
  84. GC67701 Ulodesine Ulodesine  Chemical Structure
  85. GC67697 XZ426 XZ426  Chemical Structure
  86. GC67693 Saccharopine hydrochloride Saccharopine hydrochloride  Chemical Structure
  87. GC67682 (S,S)-GSK321 (S,S)-GSK321  Chemical Structure
  88. GC67670 L-Cysteine S-sulfate sodium hydrate L-Cysteine S-sulfate sodium hydrate  Chemical Structure
  89. GC52478 Telmisartan Acyl-β-D-Glucuronide (hydrate) A major metabolite of telmisartan Telmisartan Acyl-β-D-Glucuronide (hydrate)  Chemical Structure
  90. GC52413 5-Aminosalicylic Acid-d7 An internal standard for the quantification of 5-aminosalicylic acid 5-Aminosalicylic Acid-d7  Chemical Structure
  91. GC52368 DL-Sulforaphane Glutathione A metabolite of sulforaphane DL-Sulforaphane Glutathione  Chemical Structure
  92. GC52355 BimS BH3 (51-76) (human) (trifluoroacetate salt) A Bim-derived peptide BimS BH3 (51-76) (human) (trifluoroacetate salt)  Chemical Structure
  93. GC52324 3-(3-Hydroxyphenyl)propionic Acid sulfate A metabolite of certain phenols and glycosides 3-(3-Hydroxyphenyl)propionic Acid sulfate  Chemical Structure
  94. GC52306 Pentadecanoyl-L-carnitine (chloride) A CB receptor agonist Pentadecanoyl-L-carnitine (chloride)  Chemical Structure
  95. GC52290 (R)-HTS-3 An inhibitor of LPCAT3 (R)-HTS-3  Chemical Structure
  96. GC52256 CAY10794 An inhibitor of DGAT-1 CAY10794  Chemical Structure
  97. GC52236 Nonadecanoyl-L-carnitine-d3 (chloride) An internal standard for the quantification of nonadecanoyl-L-carnitine Nonadecanoyl-L-carnitine-d3 (chloride)  Chemical Structure
  98. GC52231 Heptadecanoyl-L-carnitine-d3 (chloride) An internal standard for the quantification of heptadecanoyl-L-carnitine Heptadecanoyl-L-carnitine-d3 (chloride)  Chemical Structure
  99. GC52227 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone An active metabolite of various polyphenols 5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone  Chemical Structure
  100. GC52223 Nonadecanoyl-L-carnitine (chloride) A long-chain acylcarnitine Nonadecanoyl-L-carnitine (chloride)  Chemical Structure
  101. GC52219 Heptadecanoyl-L-carnitine (chloride) A long-chain acylcarnitine Heptadecanoyl-L-carnitine (chloride)  Chemical Structure

Items 1 to 100 of 3139 total

per page
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

Set Descending Direction