Proteases
Proteases is a general term for a class of enzymes that hydrolyze protein peptide chains. According to the way they degrade polypeptides, they are divided into two categories: endopeptidases and telopeptidases. The former can cut the large molecular weight polypeptide chain from the middle to form prions and peptones with smaller molecular weights; the latter can be divided into carboxypeptidase and aminopeptidase, which respectively remove the peptide from the free carboxyl terminus or free amino terminus of the polypeptide one by one. Chain hydrolysis produces amino acids.
A general term for a class of enzymes that hydrolyze peptide bonds in proteins. According to the way they hydrolyze polypeptides, they can be divided into endopeptidases and exopeptidases. Endopeptidase cleaves the interior of the protein molecule to form smaller molecular weight peptones and peptones. Exopeptidase hydrolyzes peptide bonds one by one from the end of the free amino group or carboxyl group of protein molecules, and frees amino acids, the former is aminopeptidase and the latter is carboxypeptidase. Proteases can be classified into serine proteases, sulfhydryl proteases, metalloproteases and aspartic proteases according to their active centers and optimum pH. According to the optimum pH value of its reaction, it is divided into acidic protease, neutral protease and alkaline protease. The proteases used in industrial production are mainly endopeptidases.
Proteases are widely found in animal offal, plant stems and leaves, fruits and microorganisms. Microbial proteases are mainly produced by molds and bacteria, followed by yeast and actinomycetes.
Enzymes that catalyze the hydrolysis of proteins. There are many kinds, the important ones are pepsin, trypsin, cathepsin, papain and subtilisin. Proteases have strict selectivity for the reaction substrates they act on. A protease can only act on certain peptide bonds in protein molecules, such as the peptide bonds formed by the hydrolysis of basic amino acids catalyzed by trypsin. Proteases are widely distributed, mainly in the digestive tract of humans and animals, and are abundant in plants and microorganisms. Due to limited animal and plant resources, the industrial production of protease preparations is mainly prepared by fermentation of microorganisms such as Bacillus subtilis and Aspergillus terrestris.
Products for Proteases
- Caspase(58)
- Aminopeptidase(13)
- ACE(61)
- Calpains(2)
- Carboxypeptidase(6)
- Cathepsin(34)
- DPP-4(5)
- Elastase(18)
- Gamma Secretase(25)
- HCV Protease(13)
- HSP(74)
- HIV Integrase(19)
- HIV Protease(18)
- MMP(139)
- Serine Protease(6)
- Thrombin(28)
- Other Proteases(12)
- Tyrosinases(35)
- 15-PGDH(1)
- Acetyl-CoA Carboxylase(11)
- Acyltransferase(47)
- Aldehyde Dehydrogenase (ALDH)(23)
- Aminoacyl-tRNA Synthetase(9)
- ATGL(1)
- Dipeptidyl Peptidase(35)
- Drug Metabolite(420)
- E1/E2/E3 Enzyme(68)
- Endogenous Metabolite(1400)
- FABP(8)
- Farnesyl Transferase(19)
- Glutaminase(13)
- Glutathione Peroxidase(13)
- Isocitrate Dehydrogenase (IDH)(23)
- Lactate Dehydrogenase(16)
- Lipoxygenase(220)
- Mitochondrial Metabolism(185)
- NEDD8-activating Enzyme(5)
- Neprilysin(12)
- PAI-1(10)
- Ser/Thr Protease(30)
- Tryptophan Hydroxylase(9)
- Xanthine Oxidase(14)
- MALT1(10)
- PCSK9(1)
- Cat.No. Product Name Information
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GC26092
Z-LEHD-FMK TFA
Z-LEHD-FMK TFA (Caspase-9 Inhibitor) is a cell-permeable, competitive and irreversible inhibitor of enzyme caspase-9, which helps in cell survival.
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GC26017
UK-371804 HCl
UK-371804 is a potent and selective urokinase-type plasmogen activator (uPA) inhibitor with excellent enzyme potency (Ki=10 nM) and selectivity profile (4000-fold versus tPA and 2700-fold versus plasmin).
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GC25727
PF-06446846
PF-06446846 is an orally active proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitor. PF-06446846 selectively inhibits translation of PCSK9 by stalling the 80S ribosome in the proximity of codon region.
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GC25726
PF-05221304
PF-05221304 is an orally bioavailable, liver-targeted inhibitor of acetyl-CoA carboxylase (ACC), an enzyme that catalyzes the first committed step in de novo lipogenesis (DNL).
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GC25723
Perindopril L-Arginine
Perindopril L-Argininel is a prodrug that is metabolized in the liver to its active diacid metabolite perindoprilat, which is rapidly and extensively absorbed, and become one of the highest tissue angiotensin-converting enzyme (ACE) affinities among the ACE inhibitors.
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GC25536
JHU395
JHU395 is a novel orally bioavailable GA (glutamine antagonists) prodrug designed to circulate inert in plasma, but permeate and release active GA within target tissues. JHU395 delivers active GA to malignant peripheral nerve sheath tumor (MPNST), and significantly inhibits tumor growth without observed toxicity.
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GC25337
D-Carnitine hydrochloride
D-Carnitine hydrochloride ((S)-Carnitine hydrochloride, (+)-Carnitine hydrochloride) is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids.
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GC25188
Calcium 2-oxoglutarate
Calcium 2-oxoglutarate (Calcium oxoglurate, Calcium 2-oxopentanedioate, Calcium α-ketoglutarate, Calcium AKG, Calcium 2-ketoglutaric acid, Calcium oxoglutaric acid) is the Calcium salt form of 2-oxoglutarate. 2-oxoglutarate is naturally found in organisms and is a well-known intermediate in the production of ATP or GTP in the Krebs cycle. 2-oxoglutarate is a reversible inhibitor of tyrosinase with IC50 of 15 mM.
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GC25117
Azvudine
Azvudine (RO-0622) is a novel nucleoside reverse transcriptase inhibitor with antiviral activity against human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV), potently inhibits HIV-1 (EC50 range 0.03 to 6.92 nM) and HIV-2 (EC50s ranging from 0.018 to 0.025 nM).
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GC68478
Bictegravir sodium
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GC68468
MPO-IN-3
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GC68464
ALDH1A3-IN-1
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GC68462
ALDH1A3-IN-2
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GC68453
ITMN 4077
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GC68450
Hsp90-IN-17 hydrochloride
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GC68426
17a-Hydroxypregnenolone-d3
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GC68421
L-Aspartic acid-13C4,15N
-
GC68417
Homovanillic acid-d5
-
GC68415
Glycolic acid-d2
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GC68414
(Rac)-Atropine-d3
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GC68399
Isolindleyin
-
GC68395
L-Isoleucine-d10
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GC68387
FGN849
-
GC68384
DL-Mevalonolactone-d7
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GC68382
L-Cysteine-1-13C
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GC68380
Sarcosine-15N
-
GC68375
Cholic acid-13C
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GC68374
5a-Pregnane-3,20-dione-d6
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GC68351
DL-Homocysteine-d4
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GC68329
Normetanephrine-d3 hydrochloride
-
GC68324
3-Methoxytyramine-d4 hydrochloride
-
GC68310
S-Adenosyl-L-methionine-d3
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GC68302
AS-Inclisiran
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GC68228
5-Nitro-1,10-phenanthroline
-
GC68218
Mepazine
-
GC68216
L-Valine-1-13C
-
GC68215
Glycine-1-13C
-
GC68214
DL-Alanine-13C-1
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GC68150
BC-1382
-
GC68149
L-Serine-15N
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GC68148
L-Tyrosine-d2
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GC68143
L-Methionine-1-13C
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GC68142
D-Phenylalanine-d5
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GC68097
Acetyl-L-carnitine-d3 hydrochloride
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GC68082
3,4,5-Trimethoxyphenylacetic acid
-
GC68055
4-Hydroxyphenyl acetate
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GC68053
L-Tyrosine-1-13C
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GC68052
Pyruvic acid 13C sodium
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GC68049
L-Aspartic acid-1,4-13C2
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GC68042
DL-Homocystine-3,3,3',3',4,4,4',4'-d8
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GC68038
L-Tyrosine D4
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GC68022
L-Methionine-15N
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GC68020
L-Glutamic acid-1-13C
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GC68013
CDE-096
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GC68009
KS106
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GC68008
GÜ2602
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GC67997
Aminopeptidase-IN-1
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GC67993
(Rac)-Cotinine-d4
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GC67992
MLT-747
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GC67988
6-Hydroxybenzbromarone
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GC67978
Paltimatrectinib
-
GC67976
D-Glucose-13C
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GC67975
Hexacosanoic acid-d4-1
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GC67973
L-Alanine-13C2
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GC67952
Hippuric acid-d5
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GC67951
5-Hydroxytryptophol-d4
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GC67947
Triolein 13C3
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GC67942
Stearic acid-d3
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GC67918
MPO-IN-1
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GC67916
Palmitic acid-d4
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GC67911
L-Serine-1-13C
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GC67910
L-Citrulline-13C
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GC67902
3-Amino-2-oxazolidinone-d4
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GC67898
GLS-1-IN-1
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GC67835
Glycocholic acid sodium
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GC67782
ALDH1A2-IN-1
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GC67781
Diaplasinin
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GC67771
GSK321
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GC67766
Abiraterone sulfate
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GC67761
(Z)-10-Hydroxynortriptyline-d3
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GC67751
Berotralstat dihydrochloride
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GC67731
S-(2-Carboxypropyl)-L-cysteine
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GC67701
Ulodesine
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GC67697
XZ426
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GC67693
Saccharopine hydrochloride
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GC67682
(S,S)-GSK321
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GC67670
L-Cysteine S-sulfate sodium hydrate
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GC52478
Telmisartan Acyl-β-D-Glucuronide (hydrate)
A major metabolite of telmisartan
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GC52413
5-Aminosalicylic Acid-d7
An internal standard for the quantification of 5-aminosalicylic acid
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GC52368
DL-Sulforaphane Glutathione
A metabolite of sulforaphane
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GC52355
BimS BH3 (51-76) (human) (trifluoroacetate salt)
A Bim-derived peptide
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GC52324
3-(3-Hydroxyphenyl)propionic Acid sulfate
A metabolite of certain phenols and glycosides
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GC52306
Pentadecanoyl-L-carnitine (chloride)
A CB receptor agonist
-
GC52290
(R)-HTS-3
An inhibitor of LPCAT3
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GC52256
CAY10794
An inhibitor of DGAT-1
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GC52236
Nonadecanoyl-L-carnitine-d3 (chloride)
An internal standard for the quantification of nonadecanoyl-L-carnitine
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GC52231
Heptadecanoyl-L-carnitine-d3 (chloride)
An internal standard for the quantification of heptadecanoyl-L-carnitine
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GC52227
5-(3',4'-Dihydroxyphenyl)-γ-Valerolactone
An active metabolite of various polyphenols
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GC52223
Nonadecanoyl-L-carnitine (chloride)
A long-chain acylcarnitine
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GC52219
Heptadecanoyl-L-carnitine (chloride)
A long-chain acylcarnitine