(4-Aminobenzoyl)-D-glutamic acid (Compound 17) exhibits competitive inhibitory activity against H 2 -pteroate synthesis system, which affects the synthesis of folate, thereby inhibiting growth of bacteria [1].
References:
[1]. Thijssen HH. P-Aminobenzoic acid derivatives as inhibitors of the cell-free H2-pteroate synthesizing system of Escherichia coli. J Med Chem. 1977 Feb;20(2):233-6.
References:
[1]. Thijssen HH. P-Aminobenzoic acid derivatives as inhibitors of the cell-free H2-pteroate synthesizing system of Escherichia coli. J Med Chem. 1977 Feb;20(2):233-6.