DNA Damage/DNA Repair

ATR inhibitor,potent and selective

ATR kinase inhibitor

Tubastatin A HCl (Tubastatin A HCl) is a potent and selectiveHDAC6inhibitor withIC50of 15 nM in a cell-free assay, and is selective (1000-fold more) against all other isozymes except HDAC8 (57-fold more). Tubastatin A HCl also inhibits HDAC10 and metallo-β-lactamase domain-containing protein2 (MBLAC2).

Zidovudine is a synthetic nucleoside analog that blocks replication of the human immunodeficiency virus (HIV) by inhibiting reverse transcriptase.

Epirubicin HCl (4'-Epidoxorubicin hydrochloride), a semisynthetic L-arabino derivative of doxorubicin, has an antineoplastic agent by inhibiting Topoisomerase. Epirubicin HCl inhibits DNA and RNA synthesis. Epirubicin HCl is a Forkhead box protein p3 (Foxp3) inhibitor and inhibits regulatory T cell activity.

DNA intercalator,Topo II inhibitor

Moxifloxacin HCl (BAY 12-8039) is an oral 8-methoxyquinolone antimicrobial for use in the treatment of acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and community-acquired pneumonia.

HDAC1 inhibitor

Irinotecan is a topoisomerase inhibitor used primarily for the treatment of colorectal cancer. Irinotecan binds to the topoisomerase I-DNA complex, preventing DNA strand reconnection and leading to DNA double-strand breaks and cell death.

Pyrimidinecarboxylic acid

MK-4827 tosylate (MK-4827 tosylate) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with an IC50 of 3.8 and 2.1 nM, respectively. MK-4827 tosylate leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.

Tankyrase inhibitor

Topoisomerase II inhibitor,intracellular ion chelator,cardioprotective agent

Fluoroquinolones,antibiotics

DNPK inhibitor,ATP-competitive and potent

MK-4827 hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively. MK-4827 hydrochloride leads to inhibition of repair of DNA damage, activates apoptosis and shows anti-tumor activity.

Potent MTH1 inhibitor

PARP inhibitor,potent and selective

High affinity adenine receptor agonist

BIBR 1532 is a potent small molecule inhibitor of human telomerase, with an IC 50 value of 5μM for telomerase inhibition. BIBR 1532 causes telomeres to shorten and reduces tumor cell proliferation.

Temozolomide is an oral activity alkylating agent that induces the formation of O6-methylguanine in DNA, which mispairs with thymine during the following cycle of DNA replication, leading to activation of the apoptotic pathways, Temozolomide could crosses the blood-brain barrier and is indicated for malignant gliomas and metastatic melanomas.

Busulfan is an alkylating drug alkylates DNA, with an IC 50 value of 77μM for human serum Paraoxonase 1.

pyrimidine nucleoside

FT-207 (NSC 148958) (FT 207; NSC 148958) is a chemotherapeutic 5-FU prodrug used in the treatment of cancers; is a component of tegafur-uracil.