GLPBio

5-Lipoxygenase

5-lipoxygenase catalyzes oxidation of AA at the 5-position to yield 5-HpETE and is a current target for pharmaceutical intervention in a number of diseases such as asthma, atherosclerosis and several cancers.

Products Related to 5-Lipoxygenase(17)

  • GC10451 structure
    GC10451U-73122
    CAS: 112648-68-7
    Purity: >98.00%

    U-73122 is a potent and selective phospholipase C (PLC) inhibitor with an IC 50 value of approximately 1-2.1µM. It also inhibits 5-lipoxygenase (5-LO).

  • GC14435 structure
    GC14435Zileuton sodium
    CAS: 118569-21-4
    Purity: >98%

    5-lipoxygenase and leukotrienes inhibitor

  • GC14751 structure
    GC14751Malotilate
    CAS: 59937-28-9
    Purity: >99.50%

    Stimulates hepatocyte regeneration

  • GC16014 structure
    GC16014Zileuton
    CAS: 111406-87-2
    Purity: >99.00%

    Zileuton, a benzothiophene N-hydroxyurea, is an oral inhibitor of 5-Lipoxygenase.

  • GC10331 structure
    GC10331Ebselen
    CAS: 60940-34-3
    Purity: 99.97%

    Ebselen is a selenoorganic compound with glutathione peroxidase-like activity and is an anti-inflammatory and antioxidant agent. Ebselen is an inhibitor of inositol monophosphatase (IMPase) with an IC 50 of 1.5μM.

  • GC10709 structure
    GC10709BW-B 70C
    CAS: 134470-38-5
    Purity: >98%

    5-Lipoxygenase inhibitor,potent and selective

  • GC10821 structure
    GC1082111-keto-β-Boswellic Acid
    CAS: 17019-92-0
    Purity: >99.50%

    11-Keto-beta-boswellic acid (11-Keto-β-boswellic acid) is a pentacyclic triterpenic acid of the oleogum resin from the bark of the Boswellia serrate tree, popularly known as Indian Frankincense. 11-Keto-beta-boswellic acid has the anti-inflammatory activity is primarily due to inhibit 5-lipoxygenase (5-LOX) and subsequent leukotriene and nuclear factor-kappa B (NF-κB) activation and tumor necrosis factor alpha generation production.

  • GC12159 structure
    GC12159HZ52
    CAS: 1077626-51-7
    Purity: >98%

    5-lipoxygenase inhibitor

  • GC12205 structure
    GC12205PD 146176
    CAS: 4079-26-9
    Purity: >98.00%

    PD 146176 is one of the potent and selective inhibitors of reticulocyte 15-LOX-1.

  • GC12232 structure
    GC12232BAY-X 1005
    CAS: 128253-31-6
    Purity: >98.50%

    BAY-X 1005 (BAY X 1005; DG-031) is an orally active and selective 5-lipoxygenase activating protein (FLAP) inhibitor.

  • GC12277 structure
    GC12277MK 886
    CAS: 118414-82-7
    Purity: >99.50%

    MK 886 is a 5-lipoxygenase-activating protein (FLAP) inhibitor and PPARα antagonist (IC 50 =30nM).

  • GC13379 structure
    GC133791-Naphthyl 3,5-dinitrobenzoate
    CAS: 93261-39-3
    Purity: >98%

    dual 5-lipoxygenase and microsomal prostaglandin E synthase-1 inhibitor

  • GC14282 structure
    GC14282AKBA (3-acetyl-11-keto-β-Boswellic Acid)
    CAS: 67416-61-9
    Purity: >98.00%

    AKBA (3-acetyl-11-keto-β-Boswellic Acid) is a pentacyclic triterpene acid that effectively and non-competitively inhibits 5-lipoxygenase (5-LOX), exhibiting various biological activities including anti-inflammatory, antitumor, and neuroprotective effects.

  • GC14601 structure
    GC14601BW 755C
    CAS: 66000-40-6
    Purity: >98%

    dual inhibitor of 5-lipoxygenase (5-LO) and cyclooxygenase (COX) pathways

  • GC15961 structure
    GC15961β-acetyl-Boswellic Acid
    CAS: 5968-70-7
    Purity: >98%

    β-acetyl-Boswellic Acid is a boswellic acid isolated from Boswellia serrata gum resin.

  • GC16046 structure
    GC16046Piriprost (potassium salt)
    CAS: 88851-62-1
    Purity: >98%

    5-lipoxygenase inhibitor

  • GC17951 structure
    GC179512-TEDC
    CAS: 132465-10-2
    Purity: >98%

    5-, 12-, and 15-lipoxygenase inhibitor