Acamelin |
Catalog No.GC80126
One-Click Copy Product Info
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Acamelin is a Benzofuranoquinone compound that acts as a contact sensitizer.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 74161-27-6
Sample solution is provided at 25 µL, 10mM.
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In Vivo, Acamelin (1% concentration; epicutaneous; single application) acts as a contact sensitizer in sensitized Pirbright white-strain guinea pigs, eliciting positive skin reactions in all tested animals, with slightly stronger and longer-lasting responses than 2,6-Dimethoxy-1,4-benzoquinone [1].
References:
[1]. Hausen BM, et al. Quinonoid constituents as contact sensitisers in Australian blackwood (Acacia melanoxylon RBR). British journal of industrial medicine. 1981 May;38(2):105-9.
[2]. McKittrick B A, et al. A simple synthesis of the natural benzofuranoquinone, acamelin[J]. Journal of the Chemical Society, Perkin Transactions 1, 1983, 12: 2423-2424.
[3]. Schmalle H W, et al. Acamelin, A new sensitizing furano-quinone from Acacia melanoxylon R. BR[J]. Tetrahedron Letters, 1980, 21(2): 149-152.
[4]. Mann J, et al. Rearrangements of aryl-8-oxabicyclo [3.2. 1] octenones: synthesis of novel biaryls and 1-aryl-3-furylpropanones[J]. Journal of the Chemical Society, Chemical Communications, 1985, 21(21): 1543-1544.
| Cas No. | 74161-27-6 | SDF | |
| Formula | C10H8O4 | M.Wt | 192.17 |
| Solubility | Storage | Store at -20°C | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 5.2037 mL | 26.0186 mL | 52.0373 mL |
| 5 mM | 1.0407 mL | 5.2037 mL | 10.4075 mL |
| 10 mM | 520.4 μL | 2.6019 mL | 5.2037 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)