Adrenalone HCl |
| Catalog No.GC13814 |
Decoyinine (Angustmycin A), a specific inhibitor of bacterial GMPS, has been isolated from Streptomyces .
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Cas No.: 62-13-5
Sample solution is provided at 25 µL, 10mM.
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Decoyinine (Angustmycin A), a specific inhibitor of bacterial GMPS, has been isolated from Streptomyces hygroscopius as a potential antibiotic with sporulation-inducing activity in Bacillus subtilis[1-3]. Angustmycin A was also recently found to be a promising cytokinin that induces adventitious root or bud differentiation[5].
With 2 mM of Angustmycin A treatment of SK-Mel-28 and SK-Mel103 cells reduced their invasion by ~30% compared with vehicle-treated cells[4]. Decoyinine (Angustmycin A) (>1mM) enabled the S. griseus IFO 13189 cells to develop aerial mycelia in the suppressed cultures at concentrations which only partially inhibited growth[6].
Decoyinine (Angustmycin A)(120 mg/kg; i.p., 10days) treatment resulted in a 36% reduction of xenografts volume while MMF caused only 19% volume reduction in SK-Mel-103 mcie. In SK-Mel-28 mcie, the xenograft volume reduction caused by angustmycin A(120 mg/kg; i.p., 27days) and MMF were of 62% and 30%, respectively[4].
References:
[1]. Vasantha N, Freese E. Enzyme changes during Bacillus subtilis sporulation caused by deprivation of guanine nucleotides. J Bacteriol. 1980 Dec;144(3):1119-25. doi: 10.1128/jb.144.3.1119-1125.1980. PMID: 6777366; PMCID: PMC294778.
[2]. Ikehara K, Okamoto M, et,al. Induction of Bacillus subtilis sporulation by decoyinine and the concomitant disappearance of ppGpp in vegetative cells. J Biochem 1982; 91: 1089-1092.
[3]. Mitani T, Heinze JE, et,al. Induction of sporulation in Bacillus subtilis by decoyinine or hadacidin. Biochem Biophys Res Commun 1977; 77: 1118-1125.
[4]. Bianchi-Smiraglia A, Wawrzyniak JA, et,al.Pharmacological targeting of guanosine monophosphate synthase suppresses melanoma cell invasion and tumorigenicity. Cell Death Differ. 2015 Nov;22(11):1858-64. doi: 10.1038/cdd.2015.47. Epub 2015 Apr 24. PMID: 25909885; PMCID: PMC4648332.
[5]. Hong-Yuan, X., Hong-Zhang, X., et,al. in Biotechnology and Sustainable Agriculture 2006 and Beyond (eds. Xu, Z., Li, J., Xue, Y. & Yang, W.) 97-101 (Springer Netherlands, 2010).
[6]. Ochi K. Metabolic initiation of differentiation and secondary metabolism by Streptomyces griseus: significance of the stringent response (ppGpp) and GTP content in relation to A factor. J Bacteriol. 1987 Aug;169(8):3608-16. doi: 10.1128/jb.169.8.3608-3616.1987. PMID: 3112126; PMCID: PMC212439.
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