GLPBio

ALK

ALK (anaplastic lymphoma kinase) is a member of insulin receptor protein-tyrosine superfamily, functioning in embryonic development and involved in cell survival and cell fate.

Products Related to ALK(62)

  • GC14189 structure
    GC14189AZD-3463
    CAS: 1356962-20-3
    Purity: >99.50%

    ALK/IGF1R inhibitor

  • GC14552 structure
    GC14552LDK378
    CAS: 1032900-25-6
    Purity: >99.50%

    LDK378 (LDK378) is a selective, orally bioavailable, and ATP-competitive ALK tyrosine kinase inhibitor with an IC50 of 200 pM.

  • GC17035 structure
    GC17035LDN-212854
    CAS: 1432597-26-6
    Purity: >98.00%

    BMP receptor inhibitor,potent and selective

  • GC17582 structure
    GC17582ML347
    CAS: 1062368-49-3
    Purity: >98.00%

    BMP receptor inhibitor,potent and selective

  • GC12273 structure
    GC12273GSK1838705A
    CAS: 1116235-97-2
    Purity: >99.00%

    GSK1838705A is a small-molecule kinase inhibitor that targets Insulin-like Growth Factor 1 Receptor (IGF-1R) and the insulin receptor, with IC₅₀ values of 2.0nM and 1.6nM, respectively.

  • GC13136 structure
    GC13136(S)-Crizotinib
    CAS: 1374356-45-2
    Purity: >99.50%

    Potent MTH1 inhibitor

  • GC13225 structure
    GC13225LDN-214117
    CAS: 1627503-67-6
    Purity: >99.50%

    potent and selective ALK2 inhibitor

  • GC13902 structure
    GC13902KRCA 0008
    CAS: 1472795-20-2
    Purity: >98.50%

    Ack1 and anaplastic lymphoma kinase (ALK) dual inhibitor

  • GC14349 structure
    GC14349SB525334
    CAS: 356559-20-1
    Purity: >98.00%

    SB525334 has been characterized as a potent and selective inhibitor of the transforming growth factor-beta1 (TGF-beta1) receptor, activin receptor-like kinase (ALK5). SB525334 inhibited ALK5 kinase activity with an IC 50 of 14.3nM.

  • GC14446 structure
    GC14446ASP3026
    CAS: 1097917-15-1
    Purity: >99.50%

    An ALK inhibitor

  • GC14476 structure
    GC14476Entrectinib
    CAS: 1108743-60-7
    Purity: >99.00%

    Entrectinib is an orally active, blood brain barrier(BBB)-penetrated and centrally active inhibitor of TrkA/B/C, ROS1 and ALK, with IC 50 values of 1, 3, 5, 12 and 7nM, respectively.

  • GC14729 structure
    GC14729(R)-Crizotinib
    CAS: 877399-52-5
    Purity: >99.50%

    A c-MET and ALK receptor tyrosine kinase inhibitor

  • GC14794 structure
    GC14794PF-06463922
    CAS: 1454846-35-5
    Purity: >99.50%

    PF-06463922 is a novel, orally active dual inhibitor of ALK (IC 50 =15-113nM) and ROS1 (K i s=0.025-0.7nM).

  • GC14931 structure
    GC14931LDN193189 Hydrochloride
    CAS: 1062368-62-0
    Purity: >98.50%

    LDN193189 (hydrochloride) is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

  • GC15145 structure
    GC15145CEP-28122
    CAS: 1022958-60-6
    Purity: >98%

    anaplastic lymphoma kinase (ALK) inhibitor

  • GC15273 structure
    GC15273CEP-37440
    CAS: 1391712-60-9
    Purity: >99.50%

    FAK/ALK inhibitor,potent and selective

  • GC16025 structure
    GC16025CH5424802
    CAS: 1256580-46-7
    Purity: >99.50%

    CH5424802 (CH5424802) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. CH5424802 demonstrates effective central nervous system (CNS) penetration.

  • GC16580 structure
    GC16580LDN-193189
    CAS: 1062368-24-4
    Purity: >99.00%

    ALK inhibitor,potent and selective

  • GC16694 structure
    GC16694TAE684 (NVP-TAE684)
    CAS: 761439-42-3
    Purity: >99.00%

    A selective ALK inhibitor

  • GC17283 structure
    GC17283AP26113
    CAS: 1197958-12-5
    Purity: >99.50%

    AP26113 (Brigatinib analog) is a potent and selective active inhibitor of anaplastic lymphoma kinase(ALK), Patent US20140066406 A1.

  • GC17376 structure
    GC17376ALK inhibitor 2
    CAS: 761438-38-4
    Purity: >99.50%

    An inhibitor of TSSK2

  • GC17452 structure
    GC17452LDK378 dihydrochloride
    CAS: 1380575-43-8
    Purity: >99.50%
  • GC19063 structure
    GC19063Belizatinib
    CAS: 1357920-84-3
    Purity: >97.00%

    Belizatinib is an oral, dual, potent inhibitor of ALK and TRKA, TRKB, and TRKC, with IC50 of 0.7 nM for wild-type recombinant ALK kinase.

  • GC19084 structure
    GC19084Brigatinib
    CAS: 1197953-54-0
    Purity: >99.50%

    A highly potent and selective ALK inhibitor