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Home >> Signaling Pathways >> Tyrosine Kinase

Tyrosine Kinase

Products for  Tyrosine Kinase

  1. Cat.No. Product Name Information
  2. GC41183 α-Carotene

    α-Carotene is a precursor of vitamin A that has been found in various fruits and vegetables.

     α-Carotene Chemical Structure
  3. GC38006 β-Hydroxyisovalerylshikonin Beta-hydroxyisovalerylshikonin is a natural product isolated from Lithospermium radix, acts as a potent inhibitor of protein tyrosine kinases (PTK), with IC50s of 0.7μM and 1μM for EGFR and v-Src receptor, respectively. Beta-hydroxyisovalerylshikonin is effective against a wide variety of tumor cell lines, and most efficiently induces cell-death in NCI-H522 and DMS114 cells. β-Hydroxyisovalerylshikonin Chemical Structure
  4. GC41653 (±)16(17)-DiHDPA (±)16(17)-DiHDPA is produced from cytochrome P450 epoxygenase action on docosahexaenoic acid. (±)16(17)-DiHDPA Chemical Structure
  5. GC41656 (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol 2-Arachidonoyl glycerol (2-AG) is an endogenous central cannabinoid (CB1) receptor agonist that is present at relatively high levels in the central nervous system. (±)2-(14,15-Epoxyeicosatrienoyl) Glycerol Chemical Structure
  6. GC13944 (5Z)-7-Oxozeaenol

    TAK1 mitogen-activated protein kinase kinase kinase (MAPKKK) inhibitor

     (5Z)-7-Oxozeaenol Chemical Structure
  7. GC17800 (E)-FeCP-oxindole VEGFR-2 inhibitor (E)-FeCP-oxindole Chemical Structure
  8. GC61807 (E/Z)-AG490 (E/Z)-AG490 ((E/Z)-Tyrphostin AG490) is a racemic compound of (E)-AG490 and (Z)-AG490 isomers. (E)-AG490 is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3. (E/Z)-AG490 Chemical Structure
  9. GC25000 (E/Z)-BCI (E/Z)-BCI (BCI, NSC 150117) is an inhibitor of dual specific phosphatase 1/6 (DUSP1/DUSP6) and mitogen-activated protein kinase with EC50 of 13.3 μM and 8.0 μM for DUSP6 and DUSP1 in cells, respectively. (E)-BCI induces apoptosis via generation of reactive oxygen species (ROS) and activation of intrinsic mitochondrial pathway in H1299 lung cancer cells. (E/Z)-BCI Chemical Structure
  10. GC63864 (E/Z)-Zotiraciclib hydrochloride (E/Z)-Zotiraciclib ((E/Z)-TG02) hydrochloride is a potent CDK2, JAK2, and FLT3 inhibitor. (E/Z)-Zotiraciclib hydrochloride Chemical Structure
  11. GC14729 (R)-Crizotinib A c-MET and ALK receptor tyrosine kinase inhibitor (R)-Crizotinib Chemical Structure
  12. GC19012 (R)-GNE-140

    ?A TRK kinase (TKI) inhibitor

     (R)-GNE-140 Chemical Structure
  13. GC13136 (S)-Crizotinib Potent MTH1 inhibitor (S)-Crizotinib Chemical Structure
  14. GC63797 (S)-Sunvozertinib (S)-Sunvozertinib ((S)-DZD9008), the S-enantiomer of Sunvozertinib, shows inhibitory activity against EGFR exon 20 NPH and ASV insertions, EGFR L858R/T790M mutation and Her2 exon20 YVMA insertion (IC50=51.2 nM, 51.9 nM, 1 nM, and 21.2 nM, respectively). (S)-Sunvozertinib also inhibits BTK. (S)-Sunvozertinib Chemical Structure
  15. GC13344 (Z)-FeCP-oxindole VEGFR-2 inhibitor (Z)-FeCP-oxindole Chemical Structure
  16. GC62291 (Z)-Orantinib (Z)-Orantinib ((Z)-SU6668) is a potent, selective, orally active and ATP competitive inhibitor of Flk‐1/KDR, PDGFRβ, and FGFR1, with IC50s of 2.1, 0.008, and 1.2 ?M, respectively. (Z)-Orantinib is a potent antiangiogenic and antitumor agent that induces regression of established tumors. (Z)-Orantinib Chemical Structure
  17. GC12172 1-Naphthyl PP1 Src family kinases inhibitor 1-Naphthyl PP1 Chemical Structure
  18. GC34119 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) (1-NA-PP 1 hydrochloride) is a selective inhibitor of src family kinases. 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) inhibits v-Src and c-Fyn, c-Abl, CDK2 and CAMK II with IC50s of 1.0, 0.6, 0.6, 18 and 22 μM, respectively. 1-Naphthyl PP1 hydrochloride (1-NA-PP 1 hydrochloride) Chemical Structure
  19. GC11696 1-NM-PP1 Pp60c-src inhibitor 1-NM-PP1 Chemical Structure
  20. GC42026 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is an abundant gonadal LPC (lysophosphatidylcholine). 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC Chemical Structure
  21. GC35053 123C4 123C4 is a potent, selective and competitive agonist of the receptor tyrosine kinase EPHA4, with a Ki value of 0.65 μM. 123C4 Chemical Structure
  22. GC46474 18-Deoxyherboxidiene A bacterial metabolite with antiangiogenic activity 18-Deoxyherboxidiene Chemical Structure
  23. GC33087 2,4-Pyrimidinediamine with linker 2,4-Pyrimidinediamine with linker is a VEGFR2 inhibitor extracted from patent WO2013055780A1, Page 69. 2,4-Pyrimidinediamine with linker Chemical Structure
  24. GC33519 2,5-Dihydroxybenzoic acid A benzoic acid with diverse biological activities 2,5-Dihydroxybenzoic acid Chemical Structure
  25. GC10408 2-D08 Sumoylation inhibitor 2-D08 Chemical Structure
  26. GC33319 2-Keto Crizotinib (PF-06260182) 2-Keto Crizotinib (PF-06260182) (PF-06260182) is an active lactam metabolite of crizotinib. 2-Keto Crizotinib (PF-06260182) Chemical Structure
  27. GC35095 2-Phospho-L-ascorbic acid trisodium salt 2-Phospho-L-ascorbic acid trisodium salt (2-Phospho-L-ascorbic acid trisodium) is a long-acting vitamin C derivative that can stimulate collagen formation and expression. 2-Phospho-L-ascorbic acid trisodium salt Chemical Structure
  28. GC39689 3-Hydroxy Midostaurin 3-Hydroxy Midostaurin (CGP 52421), a metabolite of PKC412, effectively inhibits FMS-like tyrosine kinase-3 (FLT3) autophosphorylation with IC50s of approximately 132 nM and 9.8 μM in culture medium and plasma, respectively. 3-Hydroxy Midostaurin is less selective but more cytotoxic than PKC412. 3-Hydroxy Midostaurin Chemical Structure
  29. GC25017 4,4'-Bis(4-aminophenoxy)biphenyl 4,4'-Bis(4-aminophenoxy)biphenyl is a monomer for polyimide production. 4,4'-Bis(4-aminophenoxy)biphenyl Chemical Structure
  30. GC46628 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline A building block and synthetic intermediate 4-Chloro-6,7-bis(2-methoxyethoxy)quinazoline Chemical Structure
  31. GC12818 4-methyl Erlotinib EGFR inhibitor 4-methyl Erlotinib Chemical Structure
  32. GC63805 4SC-203 4SC-203 is a potent multikinase inhibitor with potential antineoplastic activity. 4SC-203 selectively FLT3/STK1, FLT3 mutated forms, and VEGFRs. 4SC-203 Chemical Structure
  33. GC11205 5'-Fluoroindirubinoxime FMS-like receptor tyrosine kinase-3 (FLT3) inhibitor 5'-Fluoroindirubinoxime Chemical Structure
  34. GC50157 6bK Insulin degrading enzyme (IDE) inhibitor 6bK Chemical Structure
  35. GC16853 7,8-Dihydroxyflavone Tyrosine kinase receptor B (TrkB) agonist 7,8-Dihydroxyflavone Chemical Structure
  36. GC32992 7-Hydroxy-4-chromone (7-Hydroxychromone) 7-Hydroxychromone is a Src kinase inhibitor with an IC50 of <300 μM. 7-Hydroxy-4-chromone (7-Hydroxychromone) Chemical Structure
  37. GC42616 7-oxo Staurosporine

    7-oxo Staurosporine is an antibiotic originally isolated from S.

     7-oxo Staurosporine Chemical Structure
  38. GC48840 9-Methoxyellipticine An alkaloid with anticancer activity 9-Methoxyellipticine Chemical Structure
  39. GC35209 A 419259 An inhibitor of Src family kinases A 419259 Chemical Structure
  40. GC17789 A 419259 trihydrochloride LCK inhibitor, orally available A 419259 trihydrochloride Chemical Structure
  41. GC35213 A-770041 A-770041 is a selective and orally active Src-family Lck inhibitor. A-770041 Chemical Structure
  42. GC35214 A-9758 A-9758 is a RORγ ligand and a potent, selective RORγt inverse agonist (IC50=5 nM), and exhibits robust potency against IL-17A release. A-9758 Chemical Structure
  43. GC10938 AAL-993 VEGF receptors inhibitor AAL-993 Chemical Structure
  44. GC65894 ABN401 ABN401 is a highly potent and selective ATP-competitive c-MET inhibitor with an IC50 value of 10 nM. ABN401 has cytotoxic activity against MET-addicted cancer cells. ABN401 can inhibit c-MET phosphorylation in tumor tissues. ABN401 can be used for researching anticancer. ABN401 Chemical Structure
  45. GC13257 AC480 (BMS-599626) AC480 (BMS-599626) (AC480) is a selective and orally bioavailable HER1 and HER2 inhibitor, with IC50s of 20 and 30 nM, respectively. AC480 (BMS-599626) displays ~8-fold less potent to HER4 (IC50=190 nM), >100-fold to VEGFR2, c-Kit, Lck, MEK. AC480 (BMS-599626) inhibits tumor cell proliferation, and has potential to increase tumor response to radiotherapy. AC480 (BMS-599626) Chemical Structure
  46. GC18167 AC710

    A potent and selective PDGFR family inhibitor

     AC710 Chemical Structure
  47. GC35225 AC710 Mesylate AC710 Mesylate is a potent PDGFR inhibitor with Kds of 0.6, 1.57, 1, 1.3, 1.0 nM for FLT3, CSF1R, KIT, PDGFRα and PDGFRβ, respectively. AC710 Mesylate Chemical Structure
  48. GC30242 Acrizanib Acrizanib (LHA510) is a VEGFR-2 inhibitor, with an IC50 of 17.4 nM for BaF3-VEGFR-2. Acrizanib Chemical Structure
  49. GC15801 ACTB-1003 ACTB-1003 (ACTB-1003) is an oral kinase inhibitor with IC50s of 6, 2 and 4 nM for FGFR1, VEGFR2 and Tie-2. ACTB-1003 Chemical Structure
  50. GC32797 AD80 AD80, a multikinase inhibitor, inhibits RET, RAF,SRCand S6K, with greatly reduced mTOR activity. AD80 Chemical Structure
  51. GC15579 Adaphostin P210bcr/abl tyrosine kinase inhibitor Adaphostin Chemical Structure
  52. GC11892 AEE788 (NVP-AEE788) AEE788 (NVP-AEE788) is an inhibitor of the EGFR and ErbB2 with IC50 values of 2 and 6 nM, respectively. AEE788 (NVP-AEE788) Chemical Structure
  53. GC10707 Afatinib dimaleate An inhibitor of EGFR and ErbB2 Afatinib dimaleate Chemical Structure
  54. GC60567 Afatinib impurity 11 Afatinib impurity 11 is an impurity of Afatinib. Afatinib is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. Afatinib impurity 11 Chemical Structure
  55. GC13296 Afatinib(BIBW2992) A selective dual inhibitor of EGFR/HER2 Afatinib(BIBW2992) Chemical Structure
  56. GC46809 Afatinib-d6 An internal standard for the quantification of afatinib Afatinib-d6 Chemical Structure
  57. GC68628 Aflibercept

    Aflibercept (VEGF Trap) is a soluble decoy VEGFR composed of Ig domains from VEGFR1 and VEGFR2 fused to the Fc domain of human IgG1. Aflibercept inhibits the VEGF signaling pathway by blocking pathways regulated by VEGF. Aflibercept can be used in research for age-related macular degeneration (AMD) and cardiovascular diseases.

     Aflibercept Chemical Structure
  58. GC38645 AG 1295 AG 1295 Chemical Structure
  59. GC50013 AG 1478 hydrochloride Highly potent EGFR-kinase inhibitor AG 1478 hydrochloride Chemical Structure
  60. GC17489 AG 494 Potent EGFR-kinase inhibitor AG 494 Chemical Structure
  61. GC11744 AG 555 Potent EGFR-kinase inhibitor AG 555 Chemical Structure
  62. GC12233 AG 556 AG 556 is a highly selective EGFR inhibitor and also blocks LPS-induced TNF-α production. AG 556 Chemical Structure
  63. GC13168 AG 825 Selective ErbB2 inhibitor AG 825 Chemical Structure
  64. GC14494 AG 99 AG 99 ((E)-Tyrphostin 46) is a potent EGFR inhibitor. AG 99 Chemical Structure
  65. GC13697 AG-1024 Selective IGF-1R inhibitor AG-1024 Chemical Structure
  66. GC16235 AG-1295 potent and selective inhibitor of PDGF receptor kinase AG-1295 Chemical Structure
  67. GC35263 AG-13958 AG-13958 (AG-013958), a potent VEGFR tyrosine kinase inhibitor, is used for treatment of choroidal neovascularization associated with age-related macular degeneration (AMD). AG-13958 Chemical Structure
  68. GC17226 AG-1478 EGFR inhibitor,potent and selective AG-1478 Chemical Structure
  69. GC12864 AG-1557 inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase AG-1557 Chemical Structure
  70. GC17647 AG-18 AG-18 (Tyrphostin A23) is an EGFR inhibitor with an IC50 and Kiof 35 and 11 μM, respectively. AG-18 Chemical Structure
  71. GC14890 AG-183 AG-183 is the Z configuration of Lanoconazole A51. AG-183 Chemical Structure
  72. GC11024 AG-213 inhibitor of epidermal growth factor (EGF) receptor kinase AG-213 Chemical Structure
  73. GC11712 AG-370 PDGFR inhibitor AG-370 Chemical Structure
  74. GC13854 AG-490 (Tyrphostin B42) AG-490 (Tyrphostin B42) (Tyrphostin AG-490 (Tyrphostin B42)) is a tyrosine kinase inhibitor that inhibits EGFR, Stat-3 and JAK2/3. AG-490 (Tyrphostin B42) Chemical Structure
  75. GC11845 AG-82 AG-82 (AG82) is a specific inhibitor of the EGFR tyrosine kinase. AG-82 Chemical Structure
  76. GC11737 AG957 a tyrphostin that targets transforming Bcr-Abl fusion proteins AG957 Chemical Structure
  77. GC31371 AGL-2263 An inhibitor of IGF-1R AGL-2263 Chemical Structure
  78. GC16228 AIM-100 An ACK1/TNK2 inhibitor AIM-100 Chemical Structure
  79. GC66451 AKN-028 acetate AKN-028 acetate, a novel tyrosine kinase (TK) inhibitor, is a potent, orally active FMS-like receptor tyrosine kinase 3 (FLT3) inhibitor with an IC50 value of 6nM. AKN-028 acetate inhibits FLT3 autophosphorylation. AKN-028 acetate induces dose-dependent cytotoxic response (mean IC50=1μM). AKN-028 acetate induces apoptosisby activation of caspase 3. AKN-028 acetate can be used in research of acute myeloid leukemia (AML). AKN-028 acetate Chemical Structure
  80. GC35280 Alectinib Hydrochloride Alectinib Hydrochloride (CH5424802 Hydrochloride; RO5424802 Hydrochloride; AF-802 Hydrochloride) is a potent, selective, and orally available ALK inhibitor with an IC50 of 1.9 nM and a Kd value of 2.4 nM (in an ATP-competitive manner), and also inhibits ALK F1174L and ALK R1275Q with IC50s of 1 nM and 3.5 nM, respectively. Alectinib demonstrates effective central nervous system (CNS) penetration. Alectinib Hydrochloride Chemical Structure
  81. GC35287 ALK inhibitor 1 ALK inhibitor 1 (compound 17) is a potent pyrimidin ALK inhibitor. ALK inhibitor 1 is a potent inhibitor of testis-specific serine/threonine kinase 2 (TSSK2; IC50=31 nM) and focal adhesion kinase (FAK; IC50=2 nM). ALK inhibitor 1 Chemical Structure
  82. GC17376 ALK inhibitor 2 An inhibitor of TSSK2 ALK inhibitor 2 Chemical Structure
  83. GC63387 ALK kinase inhibitor-1 ALK kinase inhibitor-1 is an anaplastic lymphoma kinase (ALK) inhibitor extracted from patent US20130261106A1 compound I-202. ALK kinase inhibitor-1 Chemical Structure
  84. GC35289 ALK-IN-5 ALK-IN-5 is a potent, selective, and brain-penetrant inhibitor of anaplastic lymphoma kinase (ALK), with an IC50 of 2.9 nM. ALK-IN-5 Chemical Structure
  85. GC35290 ALK-IN-6 ALK-IN-6 (compound 11) is an orally bioavailable inhibitor of anaplastic lymphoma kinase (ALK), with IC50 values of 71 nM, 18.72 nM and 36.81 nM for ALK wild, ALK F1196M and ALK F1174L, respectively. ALK-IN-6 Chemical Structure
  86. GC64398 Almonertinib mesylate Almonertinib (HS-10296) mesylate is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib mesylate shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib mesylate is used for the research of the non-small cell lung cancer. Almonertinib mesylate Chemical Structure
  87. GC32127 Alofanib (RPT835) Alofanib (RPT835) (RPT835) is a potent and selective allosteric inhibitor of fibroblast growth factor receptor 2 (FGFR2). Alofanib (RPT835) Chemical Structure
  88. GC16604 Altiratinib c-MET/TIE-2/VEGFR inhibitor Altiratinib Chemical Structure
  89. GC11134 ALW-II-41-27

    A multi-kinase inhibitor

     ALW-II-41-27 Chemical Structure
  90. GC68647 ALW-II-49-7

    ALW-II-49-7 is a selective inhibitor of EphB2 with an intracellular EC50 of 40 nM.

     ALW-II-49-7 Chemical Structure
  91. GC15655 AMG 337 MET inhibitor AMG 337 Chemical Structure
  92. GC14974 AMG 925 FLT3/CDK4 inhibitor,potent and selective AMG 925 Chemical Structure
  93. GC35315 AMG 925 HCl AMG 925 HCl is a potent, selective, and orally available FLT3/CDK4 dual inhibitor with IC50s of 2±1 nM and 3±1 nM, respectively. AMG 925 HCl Chemical Structure
  94. GC12600 AMG-208 C-Met inhibitor,potent and highly selective AMG-208 Chemical Structure
  95. GC11481 AMG-458 Potent c-Met inhibitor AMG-458 Chemical Structure
  96. GC17669 AMG-47A destabilizer of the KRAS oncoprotein AMG-47A Chemical Structure
  97. GC67749 Amivantamab Amivantamab Chemical Structure
  98. GC64015 AMP-945 AMP-945 is an inhibitor of the enzyme focal adhesion kinase (FAK). AMP-945 Chemical Structure
  99. GC16391 Amuvatinib (MP-470, HPK 56) A multi-targeted RTK inhibitor Amuvatinib (MP-470, HPK 56) Chemical Structure
  100. GC33362 Amuvatinib hydrochloride (MP470 hydrochloride) Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is an orally bioavailable multi-targeted tyrosine kinase inhibitor with potent activity against mutant c-Kit, PDGFRα, Flt3, c-Met and c-Ret. Amuvatinib hydrochloride (MP470 hydrochloride) (MP470 hydrochloride) is also a DNA repair suppressor through suppression of DNA repair protein RAD51, thereby disrupting DNA damage repair. Antineoplastic activity. Amuvatinib hydrochloride (MP470 hydrochloride) Chemical Structure
  101. GC11486 ANA 12 TrkB receptor antagonist ANA 12 Chemical Structure

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