GLPBio

ALKBH1-IN-1

Catalog No.: GC74034Purity:>98.00%
COASDSData Sheet
ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor, with an IC50 of 0.026 μM and 1.39 μM in the fluorescence polarization and enzyme activity assay, respectively.

Products are for research use only. Not for human use. We do not sell to patients.

ALKBH1-IN-1
5 mgIn Stock
$122.00
1
10 mgIn Stock
$198.00
1
25 mgIn Stock
$419.00
1
Tel: (909) 407-4943 / (909) 689-7124Email: sales@glpbio.com

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    187(9):2288-2304 (2024)
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    183(7):1867-1883 (2020)
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Description

ALKBH1-IN-1 (Compound 13h) is a selective ALKBH1 inhibitor, with an IC50 of 0.026 μM and 1.39 μM in the fluorescence polarization and enzyme activity assay, respectively. ALKBH1-IN-1 can modulate the level of DNA 6mA modifications. ALKBH1-IN-1 can be used to study the functions of ALKBH1 and DNA 6mA.

ALKBH1-IN-1 (3 μM, 48 h) stabilizes the ALKBH1 protein in U251 cells overexpressed with ALKBH1[1].ALKBH1-IN-1 (10 μM, 48 h) increases the amount of 6mA in DNA in U251 cells[1].

References:
[1]. Xiong L, et al. Discovery of a Potent and Cell-Active Inhibitor of DNA 6mA Demetlase ALKBH1. J Am Chem Soc. 2024 Mar 13;146(10):6992-7006.

Product Documents

Purity:>98.00%Appearance:A solid
COASDSData Sheet

Chemical Properties

Molecular Formula
C16H11F3N4O4
Molecular Weight
380.28
Solubility
DMSO : ≥ 100 mg/mL (262.96 mM)
Storage
-20°C
General tips
Select a suitable solvent according to the product solubility data. Once prepared, aliquot the stock solution to avoid repeated freeze-thaw cycles.
Use stock solutions within 6 months when stored at -80°C or within 1 month when stored at -20°C.
To improve solubility, warm the tube to 37°C and sonicate it for an appropriate period.
Shipping Condition
Evaluation samples are shipped with blue ice. Other available sizes are shipped at room temperature or with blue ice upon request.

CalculatorsMolarity / Dilution / Molecular Weight / Unit Conversion / In Vivo Formulation / Solubility

g/mol

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