Aminoacyl-tRNA Synthetase

Aminoacyl-tRNA Synthetases (AARSs) are ubiquitous and evolutionarily conserved enzymes that catalyze the highly specific acylation of amino acids to cognate tRNAs. Aminoacyl-tRNA Synthetases are essential for accurate decoding of the triplet genetic code and for sustenance of all domains of life, including bacteria, archaea, and eukarya.

Aminoacyl-tRNA Synthetases also perform critical cellular activities unrelated to their primary function in aminoacylation. These noncanonical activities include regulation of gene transcription, mRNA translational control, angiogenesis, apoptosis, amino acid sensing, and cell signaling.

Products Related to Aminoacyl-tRNA Synthetase(11)

GC30293 Arg-AMS
CAS: 301351-95-1
Purity: >98.00%
Arg-AMS is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes.
GC30683 Gln-AMS
CAS: 209543-57-7
Purity: >99.50%
Gln-AMS is an aminoacyl-tRNA synthetase (AARS) inhibitor, with the K i value of 1.32μM.
GC31432 Asp-AMS
CAS: 828288-98-8
Purity: >98%
Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.
GC32121 Leu-AMS
CAS: 288591-93-5
Purity: >99.00%
Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation.
GC32149 Aminoacyl tRNA synthetase-IN-1
CAS: 219931-45-0
Purity: >99.50%
Aminoacyl tRNA synthetase-IN-1 is a bacterial aminoacyl tRNA synthetase (aaRS) inhibitor.
GC32366 GlyRS-IN-1
CAS: 112921-11-6
Purity: >98%
GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor extracted from patent WO 2017066459 A1.
GC34331 Gln-AMS TFA
Purity: >98%
Gln-AMS TFA is an aminoacyl-tRNA synthetase (AARS) inhibitor, with the K i value of 1.32μM.
GC34358 Leu-AMS R enantiomer
Purity: >98%
Leu-AMS R enantiomer is the R enatiomer of Leu-AMS.
GC65058 LysRs-IN-2
CAS: 2170696-76-9
Purity: >99.50%
LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) and Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS), respectively.
GC79562 BC-DXI-495
CAS: 2421117-94-2
Purity: >99.00%
BC-DXI-495 is a AIMP2-DX2 inhibitor.
GC81879 NCP26 TFA
Purity: >99.50%
NCP26 TFA is an ATP-competitive ProRS inhibitor (with a K D of 271 nM in the absence of proline, and a K D of 0.35 nM in the presence of 100 μM proline).

Category Product List
Catalog No.	Product Name	CAS No.	Purity
GC30293	Arg-AMS	301351-95-1	>98.00%
GC30293	Arg-AMS is a potent nanomolar inhibitor of arginyl tRNA synthetase, which displays tightly bound inhibitory characteristics for the A-domains in non-ribosomal peptide synthetases (NRPS) enzymes.
GC30683	Gln-AMS	209543-57-7	>99.50%
GC30683	Gln-AMS is an aminoacyl-tRNA synthetase (AARS) inhibitor, with the K i value of 1.32μM.
GC31432	Asp-AMS	828288-98-8	>98%
GC31432	Asp-AMS, an analogue of aspartyl-adenylate, is an aspartyl-tRNA synthetase inhibitor and also a strong competitive inhibitor of the mitochondrial enzyme.
GC32121	Leu-AMS	288591-93-5	>99.00%
GC32121	Leu-AMS (compound 6), a leucine analogue, is a potent inhibitor of leucyl-tRNA synthetase (LRS) with an IC50 of 22.34 nM, which inhibits the catalytic activity of LRS but did not affect the leucine-induced mTORC1 activation.
GC32149	Aminoacyl tRNA synthetase-IN-1	219931-45-0	>99.50%
GC32149	Aminoacyl tRNA synthetase-IN-1 is a bacterial aminoacyl tRNA synthetase (aaRS) inhibitor.
GC32366	GlyRS-IN-1	112921-11-6	>98%
GC32366	GlyRS-IN-1 is a glycyl-tRNA synthase (GlyRS) inhibitor extracted from patent WO 2017066459 A1.
GC34331	Gln-AMS TFA	-	>98%
GC34331	Gln-AMS TFA is an aminoacyl-tRNA synthetase (AARS) inhibitor, with the K i value of 1.32μM.
GC34358	Leu-AMS R enantiomer	-	>98%
GC34358	Leu-AMS R enantiomer is the R enatiomer of Leu-AMS.
GC65058	LysRs-IN-2	2170696-76-9	>99.50%
GC65058	LysRs-IN-2 is a lysyl-tRNA synthetase (KRS) inhibitor with IC50s of 0.015 μM and 0.13 μM for Plasmodium falciparum lysyl-tRNA synthetase (PfKRS) and Cryptosporidium parvum lysyl-tRNA synthetase (CpKRS), respectively.
GC79562	BC-DXI-495	2421117-94-2	>99.00%
GC79562	BC-DXI-495 is a AIMP2-DX2 inhibitor.
GC81879	NCP26 TFA	-	>99.50%
GC81879	NCP26 TFA is an ATP-competitive ProRS inhibitor (with a K D of 271 nM in the absence of proline, and a K D of 0.35 nM in the presence of 100 μM proline).